BfR - Department 6: Chemicals Safety (BfR - CHS)
The Department’s work encompasses the health assessment of substances (chemicals, biocides, pesticides) and preparations (pesticides and biocides). This assessment involves determining their inherent toxic properties for the purposes of classification and labelling, the establishment of limit values and the identification of exposure as elements of risk assessment. Furthermore, control methods are examined and existing test methods and strategies are developed further and new ones conceived. The Department’s assessments are used on the national, European and global levels. They are the basis for National and European risk management provisions and measures.They are also used in transport safety including international sea shipping. The Department supports the following BfR Committee: 'Committee for Pesticides and Their Residues'.
Parent institution:
Federal Institute for Risk Assessment (BfR) Details of BfR
Address
BfR - Department 6: Chemicals Safety (BfR - CHS)
Max-Dohrn-Str. 8-10
10589 Berlin
Berlin
Phone: +49-(0)30-18412-3337
Fax: +49-(0)30-18412-3008
email: 6(@)bfr.bund.de
Activities:
- Research
Focus of Research:
- Development of basics and strategies for risk assessment of nanomaterials in pesticides, biocides and chemicals
- Endocrine disruptors: Development of strategies and concepts for assessing the risk of pesticides, biocides and chemicals particularly with regard to endocrine damaging characteristics
- Improvement of knowledge of the exposition to residues of pesticides: Analyses of consumer data and development of consumer models
- Improvement of toxicological data basis: Analyses of dermal absorption of pesticides (active ingredients), analyses of interspecies differences of transport of xenobiotics in the placenta and analyses of xenobiotic metabolism in the lung
- Risk assessment of multiple residues: Research project to understand combination effects at an example of a commonly used group of fungicides (Triazole)
- Risk assessment of phthalates: Analyses of structure–activity relationships and of the metabolism of asymmetric phthalates
Coordinated projects
- Application of 2-DE-based proteomics for biomarker detection in human plasma Details of Application of 2-DE-based proteomics for biomarker detection in human plasma
- Application of 2-DE-based proteomics in vitro Details of Application of 2-DE-based proteomics in vitro
- Application of LC-MS QTrap technology in the simultaneous determination of plant protection products residues Details of Application of LC-MS QTrap technology in the simultaneous determination of plant protection products residues
- Array based analysis of endocrine-disrupting properties of selected plant protection products in the low dose range in vitro Details of Array based analysis of endocrine-disrupting properties of selected plant protection products in the low dose range in vitro
- Assay of toxic compounds in smoke of water pipes Details of Assay of toxic compounds in smoke of water pipes
- Characterisation of in vitro models for the prediction of transplacental transport of xenobiot-ics and analysis of the role of ATP-binding cassette (ABC) transporters Details of Characterisation of in vitro models for the prediction of transplacental transport of xenobiot-ics and analysis of the role of ATP-binding cassette (ABC) transporters
- Cytochrom P450 (CYP 2E1)-dependent metabolism in genetically modified cell lines Details of Cytochrom P450 (CYP 2E1)-dependent metabolism in genetically modified cell lines
- Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407) Details of Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)
- Determination of CYP2F-related enzyme activities in human lung tissue Details of Determination of CYP2F-related enzyme activities in human lung tissue
- Determination of the expression of the messenger RNA (mRNA) of xenobiotic-metabolizing Cytochrome P450 (CYP) enzymes in human lung tissue Details of Determination of the expression of the messenger RNA (mRNA) of xenobiotic-metabolizing Cytochrome P450 (CYP) enzymes in human lung tissue
- Development of a multi-polar method for monitoring pesticide metabolites in drinking water and raw water of drinking water treatment by LC-MS/MS Details of Development of a multi-polar method for monitoring pesticide metabolites in drinking water and raw water of drinking water treatment by LC-MS/MS
- Development of a simple and universal analytical method for the simultaneous determination of pesticides in tap water Details of Development of a simple and universal analytical method for the simultaneous determination of pesticides in tap water
- Examination of flame retardants with emphasis on polybrominated diphenyl ethers (PBDEs) in human mothers milk from Germany Details of Examination of flame retardants with emphasis on polybrominated diphenyl ethers (PBDEs) in human mothers milk from Germany
- Exploratory study on the evaluation of the relationship betweenemissions from printers and copy machines in offices and health complaints Details of Exploratory study on the evaluation of the relationship betweenemissions from printers and copy machines in offices and health complaints
- Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells Details of Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells
- Genetic polymorphisms and variability of cytochrom P450 enzymes Details of Genetic polymorphisms and variability of cytochrom P450 enzymes
- Hepatotoxic combination effects of multiple residues of pesticides in vivo und in vitro Details of Hepatotoxic combination effects of multiple residues of pesticides in vivo und in vitro
- Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1) Details of Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1)
- Identification of CYP2F1 and CYP2S1 in human lung tissue Details of Identification of CYP2F1 and CYP2S1 in human lung tissue
- Identification of microsomal Epoxide hydrolase in human lung tissue Details of Identification of microsomal Epoxide hydrolase in human lung tissue
- Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin. Details of Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin.
- Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test Details of Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test
- Impact of chemical structure, physico-chemical substance properties, and study design on the dermal absorption rates of pesticidal/biocidal active ingredients Details of Impact of chemical structure, physico-chemical substance properties, and study design on the dermal absorption rates of pesticidal/biocidal active ingredients
- Influence of different extraction procedures on the recovery of pesticide residues analysed by liquid chromatographic methods Details of Influence of different extraction procedures on the recovery of pesticide residues analysed by liquid chromatographic methods
- International Validation of a new gas-chromatographic method for effective determination of pesticide residues Details of International Validation of a new gas-chromatographic method for effective determination of pesticide residues
- Interspecies variability between man, rabbit and rat in function and structure of major xenobiotic transport proteins in the placenta Details of Interspecies variability between man, rabbit and rat in function and structure of major xenobiotic transport proteins in the placenta
- Investigation of biomarkers of water pipe smoke Details of Investigation of biomarkers of water pipe smoke
- Investigation of the storage stability of pesticides Details of Investigation of the storage stability of pesticides
- Mechanism of toxicity of triazole fungicides Details of Mechanism of toxicity of triazole fungicides
- Methodology to develop acute exposure threshold levels in case of accidental chemical release (ACUTEX) Details of Methodology to develop acute exposure threshold levels in case of accidental chemical release (ACUTEX)
- Nanoproducts for Plant Care and Protection Details of Nanoproducts for Plant Care and Protection
- On the evaluation of carcinogenic risks due to the exposure against dioxin-like and non-dioxin-like compounds Details of On the evaluation of carcinogenic risks due to the exposure against dioxin-like and non-dioxin-like compounds
- Organotin compounds and aromatase activity: in vivo investigations during the pre-, peri- and postnatal development of rats Details of Organotin compounds and aromatase activity: in vivo investigations during the pre-, peri- and postnatal development of rats
- Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf Details of Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf
- Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances Details of Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances
- Proteomic analysis of benzo(a)pyrene responses in mouse tissues Details of Proteomic analysis of benzo(a)pyrene responses in mouse tissues
- The effect of different sea water parameters on the formation of disinfection by-products anddisinfection efficiency Details of The effect of different sea water parameters on the formation of disinfection by-products anddisinfection efficiency
- Validation Study Human Exposure of Non-Professionals to Wood Preservatives Details of Validation Study Human Exposure of Non-Professionals to Wood Preservatives
- Variability of cytochrom P450 enzymes in human lung tissue Details of Variability of cytochrom P450 enzymes in human lung tissue
Involved in research projects:
- Determining the origin of the growth hormone with isotope ratio monitoring LC / MS (irm-LC/MS) Details of Determining the origin of the growth hormone with isotope ratio monitoring LC / MS (irm-LC/MS)
- Effect of plant sterols star on the protein pattern in blood mononuclear cells of healthy women Details of Effect of plant sterols star on the protein pattern in blood mononuclear cells of healthy women
- Identification of proteins from spots of gel electrophoresis using mass spectrometry Details of Identification of proteins from spots of gel electrophoresis using mass spectrometry


