Investigations on metabolism of the skin with in vitro models
Description:
The exposure via skin and the possible formation of metabolites in / on the skin play an important role during the toxicological evaluation of consumer products with skin contact. For example azo dyes, which are applied in consumer products such as toys and clothing textiles and also for the colouring of cosmetics and as hair dyes, can be split by the microflora of the skin into aromatic amines. Some of these amines are known as carcinogenic and allergenic. In many cases the available data for metabolism of these substances is insufficient. Therefore such investigations are to be accomplished using suitable in vitro models of human skin.
Executive Institute:
BfR - Division 7: Safety of consumer products (BfR - PRS) Details of BfR - Division 7: Safety of consumer products
Parent institution:
Federal Institute for Risk Assessment (BfR) Details of (BfR) (Berlin)
Contract period:
01. 04. 2007 - 31. 12. 2008
Participating Institutions:
- Berlin Institute of Technology (TUB) Details of TUB
Funding Programme:
- BfR Funding Details of BfR Funding
Subject:
- Biotechnology
Purpose of research:
Applied research
Funding Institutions:
- Federal Institute for Risk Assessment (BfR) Details of (BfR)
Project Management Agency:
- Federal Institute for Risk Assessment (BfR) Details of BfR