Evaluation of endpoints in addition to MTT for predicting skin irritation potential of chemical substances with in vitro human reconstructed skin models.
Description:
Phase 1 of the ECVAM validation study (Project No. 1342-426) has shown that the in vitro tests can successfully discriminate clear-cut irritating chemicals from those chemicals which do not irritate the skin. However, recent new international regulations require a third class of skin irritancy to be predicted: mild irritants. The current project aimes in identifying promising toxicological endpoints for the prediction of mild irritating chemicals.
Executive Institute:
BfR – Department 3: Scientific Services (BfR - QUER) Details of BfR – Department 3: Scientific Services
Parent institution:
Federal Institute for Risk Assessment (BfR) Details of (BfR) (Berlin)
Contract period:
01. 01. 2002 - 31. 12. 2006
Funding Programme:
- BfR Funding Details of BfR Funding
Subject:
- Toxicology
Purpose of research:
Applied research
Funding Institutions:
- Federal Institute for Risk Assessment (BfR) Details of (BfR)
Project Management Agency:
- Federal Institute for Risk Assessment (BfR) Details of BfR