Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances
Description:
The aim of the project is to find a parameter as an indicator for the influence of test substances on cardiac function by calcium measurements in isolated cultured cardiomyocytes. Compared to other techniques, this should provide a meaningful method according to the guidelines for drug safety. At the same time this method has the potential to replace and reduce animal experiments.
Executive Institute:
BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments
Parent institution:
Federal Institute for Risk Assessment (BfR) Details of (BfR) (Berlin)
Contract period:
01. 08. 2007 - 31. 07. 2009
Participating Institutions:
- Institute for Molecular Cell Biology Details of Institute for Molecular Cell Biology
Funding Programme:
- BfR Funding Details of BfR Funding
Subject:
- Biotechnology
Purpose of research:
Applied research
Funding Institutions:
- Federal Institute for Risk Assessment (BfR) Details of (BfR)
Project Management Agency:
- Federal Institute for Risk Assessment (BfR) Details of BfR