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Projects of "6.7 Development and validation of alternative methods to animal testing"   View in a table View in a table

Best Search Practice on Animal Alternatives - A Guide for Untrained Database Users - Details of Best Search Practice on Animal Alternatives - A Guide for Untrained Database Users

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2006 - 2011

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Project Management Agency:

Computerised risk assessment of dermal absorption of active agents - Details of Computerised risk assessment of dermal absorption of active agents

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2004 - 2008

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Project Management Agency:

Construction and Prevalidation of V79 Pathway Cell Lines: Heterologous Co-Expression of human Cytochrom P450 1A2 and polymorphic forms of human N-Acetyltransferase in V79 Chinese Hamster Cells for in vitro-studies on toxicity and metabolism of chemicals and drugs. - Details of Construction and Prevalidation of V79 Pathway Cell Lines: Heterologous Co-Expression of human Cytochrom P450 1A2 and polymorphic forms of human N-Acetyltransferase in V79 Chinese Hamster Cells for in vitro-studies on toxicity and metabolism of chemicals and drugs.

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2001 - 2004

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Development and evaluation of alternative methods to replace animal experiments (NIH-Test) for the potency measure of vaccines against rabies - Details of Development and evaluation of alternative methods to replace animal experiments (NIH-Test) for the potency measure of vaccines against rabies

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2007 - 2010

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Development of a biotransformation system for the metabolic activation of validated in vitro systems to study embryotoxicity - Details of Development of a biotransformation system for the metabolic activation of validated in vitro systems to study embryotoxicity

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2008 - 2011

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Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances - Details of Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2007 - 2009

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Development of bioreactors for in vitro testing of biological heart valves for reduction of animal experiments - Details of Development of bioreactors for in vitro testing of biological heart valves for reduction of animal experiments

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2004 - 2006

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Development of Predictive In Vitro Test for Developmental Neurotoxicity testing - Details of Development of Predictive In Vitro Test for Developmental Neurotoxicity testing

Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

Contract period: 2007 - 2011

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    Project Management Agency:

      Embryonic stem cell-based novel alternative testing strategies (ESNATS) - Details of Embryonic stem cell-based novel alternative testing strategies (ESNATS)

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2008 - 2013

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      Equine precision cut lung slices as an in vitro model of obstructive airway diseases for the identification and characterization of drug targets - Details of Equine precision cut lung slices as an in vitro model of obstructive airway diseases for the identification and characterization of drug targets

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2007 - 2008

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      Establishment of normal human neural progenitor cells as an in vitro screening model for the evaluation of the neurotoxic potential of chemicals - Details of Establishment of normal human neural progenitor cells as an in vitro screening model for the evaluation of the neurotoxic potential of chemicals

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2007 - 2010

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      Estimating the risk of substances by spatial multi-biomarker profiling of 3D tissue cultures - Details of Estimating the risk of substances by spatial multi-biomarker profiling of 3D tissue cultures

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2006 - 2009

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      Gastric cell lines to substitute native cells of the gastric gland to study acid secretion in special consideration of preclinical studies - Details of Gastric cell lines to substitute native cells of the gastric gland to study acid secretion in special consideration of preclinical studies

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2005 - 2008

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      HPCT-1E3 hepatocytoma cultures for determination of cytotoxicity, toxicokinetic interactions and cholestatic effects, pre-validation study - Details of HPCT-1E3 hepatocytoma cultures for determination of cytotoxicity, toxicokinetic interactions and cholestatic effects, pre-validation study

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2008

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      Improvement of the embryonic stem cell test (EST) using neural marker genes for testing the developmental neurotoxicity in vitro - Details of Improvement of the embryonic stem cell test (EST) using neural marker genes for testing the developmental neurotoxicity in vitro

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2010

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      Improving the gain of transgenic mouse embryos for cryopreservation - Details of Improving the gain of transgenic mouse embryos for cryopreservation

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2005 - 2006

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      In vitro exposure of lung cells with aerosol at the air-liquid-layer as an alternative for inhalation experiments with animals - Details of In vitro exposure of lung cells with aerosol at the air-liquid-layer as an alternative for inhalation experiments with animals

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2007

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      Joint Project: Development of an in vitro embryo toxicity tests with mouse embryonic stem cells: Subproject 1 - Analysis of embryotoxic effects in the light of new endpoints and metabolism using an expanded selection of materials - Details of Joint Project: Development of an in vitro embryo toxicity tests with mouse embryonic stem cells: Subproject 1 - Analysis of embryotoxic effects in the light of new endpoints and metabolism using an expanded selection of materials

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2007

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      Project Management Agency:

      Joint project: Pluripotent stem cells in automated prediction of developmental osteotoxizität. Subproject 3: Development and establishment of a Osteoblsten differentiation assays - Details of Joint project: Pluripotent stem cells in automated prediction of developmental osteotoxizität. Subproject 3: Development and establishment of a Osteoblsten differentiation assays

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2009 - 2010

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      Project Management Agency:

      Normal human neural progenitorcells as a screening model for substances that are toxic for neural development. - Details of Normal human neural progenitorcells as a screening model for substances that are toxic for neural development.

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2007

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      Optical probe technique for the assessment of multidrug resistance profiles in 3-dimensional in vitro tumor models - Details of Optical probe technique for the assessment of multidrug resistance profiles in 3-dimensional in vitro tumor models

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2004 - 2006

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      Preparation for external prevalidation: Optimization of the internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro by determination of the angiogenic standard of the cells to be used - Details of Preparation for external prevalidation: Optimization of the internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro by determination of the angiogenic standard of the cells to be used

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2007 - 2010

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      Refinement of the LCSA (loose-fit coculture-based sensitization assay) - Details of Refinement of the LCSA (loose-fit coculture-based sensitization assay)

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2007 - 2008

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      Replacement of transgenic animal models for determination of in vivo mutations by refinement of regulatory animal studies with the technique of the Random Mutations Capture Assay - Details of Replacement of transgenic animal models for determination of in vivo mutations by refinement of regulatory animal studies with the technique of the Random Mutations Capture Assay

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2009 - 2011

      Funding Institutions:

      • Federal Ministry of Food, Agriculture and Consumer Protection (BMELV) Details of BMELV

      Project Management Agency:

      Studies on the anti-oxidative responses of lung cells as an endpoint for the assessment of aerosols after exposure at the air-liquid interface - Details of Studies on the anti-oxidative responses of lung cells as an endpoint for the assessment of aerosols after exposure at the air-liquid interface

      Executive Institute: BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET) Details of (Berlin)

      Parent institution: Federal Institute for Risk Assessment (BfR) Details of BfR

      Contract period: 2007 - 2011

      Funding Institutions:

      Project Management Agency: