Information System for Agriculture and Food Research

Coordinated projects :

• Comparative study on the quality of vegetables derived from conventional and organic farming using the example of carrots- Details of Comparative study on the quality of vegetables derived from conventional and organic farming using the example of carrots
• Molecular characterization of MRSA- Details of Molecular characterization of MRSA
• Characterization of the zoonotic potential of rotaviruses in poultry - Details of Characterization of the zoonotic potential of rotaviruses in poultry
• Food Safety - Forming a European platform for protecting consumers against health risks (SAFEFOODERA)- Details of Food Safety - Forming a European platform for protecting consumers against health risks (SAFEFOODERA)
• On the evaluation of carcinogenic risks due to the exposure against dioxin-like and non-dioxin-like compounds- Details of On the evaluation of carcinogenic risks due to the exposure against dioxin-like and non-dioxin-like compounds
• Development of a multi-polar method for monitoring pesticide metabolites in drinking water and raw water of drinking water treatment by LC-MS/MS - Details of Development of a multi-polar method for monitoring pesticide metabolites in drinking water and raw water of drinking water treatment by LC-MS/MS
• Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)- Details of Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)
• Application of LC-MS QTrap technology in the simultaneous determination of plant protection products residues- Details of Application of LC-MS QTrap technology in the simultaneous determination of plant protection products residues
• Characterisation of in vitro models for the prediction of transplacental transport of xenobiot-ics and analysis of the role of ATP-binding cassette (ABC) transporters- Details of Characterisation of in vitro models for the prediction of transplacental transport of xenobiot-ics and analysis of the role of ATP-binding cassette (ABC) transporters
• Cytochrom P450 (CYP 2E1)-dependent metabolism in genetically modified cell lines- Details of Cytochrom P450 (CYP 2E1)-dependent metabolism in genetically modified cell lines
• Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf- Details of Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf
• Variability of cytochrom P450 enzymes in human lung tissue- Details of Variability of cytochrom P450 enzymes in human lung tissue
• Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1)- Details of Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1)
• Examination of flame retardants with emphasis on polybrominated diphenyl ethers (PBDEs) in human mothers milk from Germany- Details of Examination of flame retardants with emphasis on polybrominated diphenyl ethers (PBDEs) in human mothers milk from Germany
• Genetic polymorphisms and variability of cytochrom P450 enzymes- Details of Genetic polymorphisms and variability of cytochrom P450 enzymes
• Development of a simple and universal analytical method for the simultaneous determination of pesticides in tap water- Details of Development of a simple and universal analytical method for the simultaneous determination of pesticides in tap water
• Investigation of the storage stability of pesticides- Details of Investigation of the storage stability of pesticides
• Application of 2-DE-based proteomics for biomarker detection in human plasma- Details of Application of 2-DE-based proteomics for biomarker detection in human plasma
• Influence of different extraction procedures on the recovery of pesticide residues analysed by liquid chromatographic methods- Details of Influence of different extraction procedures on the recovery of pesticide residues analysed by liquid chromatographic methods
• Application of 2-DE-based proteomics in vitro- Details of Application of 2-DE-based proteomics in vitro
• International Validation of a new gas-chromatographic method for effective determination of pesticide residues- Details of International Validation of a new gas-chromatographic method for effective determination of pesticide residues
• Proteomic analysis of benzo(a)pyrene responses in mouse tissues- Details of Proteomic analysis of benzo(a)pyrene responses in mouse tissues
• Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells- Details of Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells
• Organotin compounds and aromatase activity: in vivo investigations during the pre-, peri- and postnatal development of rats- Details of Organotin compounds and aromatase activity: in vivo investigations during the pre-, peri- and postnatal development of rats
• Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin.- Details of Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin.
• Determination of the expression of the messenger RNA (mRNA) of xenobiotic-metabolizing Cytochrome P450 (CYP) enzymes in human lung tissue- Details of Determination of the expression of the messenger RNA (mRNA) of xenobiotic-metabolizing Cytochrome P450 (CYP) enzymes in human lung tissue
• Investigation of biomarkers of water pipe smoke- Details of Investigation of biomarkers of water pipe smoke
• Assay of toxic compounds in smoke of water pipes- Details of Assay of toxic compounds in smoke of water pipes
• Identification of CYP2F1 and CYP2S1 in human lung tissue- Details of Identification of CYP2F1 and CYP2S1 in human lung tissue
• Hepatotoxic combination effects of multiple residues of pesticides in vivo und in vitro- Details of Hepatotoxic combination effects of multiple residues of pesticides in vivo und in vitro
• Exploratory study on the evaluation of the relationship betweenemissions from printers and copy machines in offices and health complaints- Details of Exploratory study on the evaluation of the relationship betweenemissions from printers and copy machines in offices and health complaints
• The effect of different sea water parameters on the formation of disinfection by-products anddisinfection efficiency- Details of The effect of different sea water parameters on the formation of disinfection by-products anddisinfection efficiency
• Array based analysis of endocrine-disrupting properties of selected plant protection products in the low dose range in vitro- Details of Array based analysis of endocrine-disrupting properties of selected plant protection products in the low dose range in vitro
• Interspecies variability between man, rabbit and rat in function and structure of major xenobiotic transport proteins in the placenta- Details of Interspecies variability between man, rabbit and rat in function and structure of major xenobiotic transport proteins in the placenta
• Impact of chemical structure, physico-chemical substance properties, and study design on the dermal absorption rates of pesticidal/biocidal active ingredients- Details of Impact of chemical structure, physico-chemical substance properties, and study design on the dermal absorption rates of pesticidal/biocidal active ingredients
• Determination of CYP2F-related enzyme activities in human lung tissue- Details of Determination of CYP2F-related enzyme activities in human lung tissue
• Nanoproducts for Plant Care and Protection- Details of Nanoproducts for Plant Care and Protection
• Identification of microsomal Epoxide hydrolase in human lung tissue- Details of Identification of microsomal Epoxide hydrolase in human lung tissue
• Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances- Details of Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances
• Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test- Details of Immunodetection of potential biomarkers for the prediction of early carcinogenic processes in the subacute toxicity test
• Methodology to develop acute exposure threshold levels in case of accidental chemical release (ACUTEX)- Details of Methodology to develop acute exposure threshold levels in case of accidental chemical release (ACUTEX)
• Validation Study Human Exposure of Non-Professionals to Wood Preservatives- Details of Validation Study Human Exposure of Non-Professionals to Wood Preservatives
• Mechanism of toxicity of triazole fungicides- Details of Mechanism of toxicity of triazole fungicides
• Identification of Nrf2-target genes in human THP-1 monocytes 2009: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis 2010: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis- Details of Identification of Nrf2-target genes in human THP-1 monocytes 2009: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis 2010: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis
• Analysis of the effects of developmental toxins from consumer products on microRNA (miRNA) expression during differentiation of embryonic stem cells. Identification of novel molecular endpoints and studies on the role of miRNAs in developmental toxicity- Details of Analysis of the effects of developmental toxins from consumer products on microRNA (miRNA) expression during differentiation of embryonic stem cells. Identification of novel molecular endpoints and studies on the role of miRNAs in developmental toxicity
• Evaluation of the genotoxic potenital of selected synthetically synthesized nanomaterials through application of alternative methods- Details of Evaluation of the genotoxic potenital of selected synthetically synthesized nanomaterials through application of alternative methods
• Description of the Nature of Accidental Misuse of Chemicals and Chemical Products (DeNaMiC)- Details of Description of the Nature of Accidental Misuse of Chemicals and Chemical Products (DeNaMiC)
• Inhalation toxicity of nano-aerosols - animal studies- Details of Inhalation toxicity of nano-aerosols - animal studies
• Prevalidation for testing the toxic effects of inhaled active substances (gases) after direct exposure of lung cells of people in the Luft-/Flüssigkeitsgrenzschicht- Details of Prevalidation for testing the toxic effects of inhaled active substances (gases) after direct exposure of lung cells of people in the Luft-/Flüssigkeitsgrenzschicht
• North Sea Ballast Water Opportunity Developing preventative and responsive measures to address acute and chronic marine pollution (Interreg IVB)- Details of North Sea Ballast Water Opportunity Developing preventative and responsive measures to address acute and chronic marine pollution (Interreg IVB)
• Support to complete EFSA\'s food consumption concise database (CFP/EFSA/DATEX/2007/01) - SuConDa- Details of Support to complete EFSA\'s food consumption concise database (CFP/EFSA/DATEX/2007/01) - SuConDa
• Project to develop Animal Risk Assessment Guidelines on housing and management (Animal Welfare)(CFP/EFSA/AHAW/2009/01) Work package 2: Hazard identification and characterisation, and exposure assessment- Details of Project to develop Animal Risk Assessment Guidelines on housing and management (Animal Welfare)(CFP/EFSA/AHAW/2009/01) Work package 2: Hazard identification and characterisation, and exposure assessment
• Phthalate exposure of the population in Germany: relevant exposure sources, intake pathways and toxicokinetics using the example of DEHP (diethylhexylphthalate)- Details of Phthalate exposure of the population in Germany: relevant exposure sources, intake pathways and toxicokinetics using the example of DEHP (diethylhexylphthalate)
• Foodborne intake of environmental contaminants - Analysis of the National Food Consumption Survey II (NVS II)- Details of Foodborne intake of environmental contaminants - Analysis of the National Food Consumption Survey II (NVS II)
• Cumarine exposition: Cinnamon as ingredient of foodstuffs. Module 1: database children; Module 2: database adolescents/adults- Details of Cumarine exposition: Cinnamon as ingredient of foodstuffs. Module 1: database children; Module 2: database adolescents/adults
• Evaluation of exposure data on consumer products (ChemTest Phase I)- Details of Evaluation of exposure data on consumer products (ChemTest Phase I)
• Development of a Technical Guidance Document for preparing the Chemical Safety Report (REACH / RIP 3.2-2)- Details of Development of a Technical Guidance Document for preparing the Chemical Safety Report (REACH / RIP 3.2-2)
• Development of an approach to adopt the Langual system for product categorisation purposes with focus on the EU exposure assessment toolbox (CCR.IHCP.C432952.X0)- Details of Development of an approach to adopt the Langual system for product categorisation purposes with focus on the EU exposure assessment toolbox (CCR.IHCP.C432952.X0)
• Characterization of the barrier function of human reconstructed skin models- Details of Characterization of the barrier function of human reconstructed skin models
• Review of consumer exposure data files contained in the \'European Exposure Assessment Toolbox\' and introuction of new data from European Chemicals Bureau Risk Assessment Reports currently under development- Details of Review of consumer exposure data files contained in the \'European Exposure Assessment Toolbox\' and introuction of new data from European Chemicals Bureau Risk Assessment Reports currently under development
• Validation study for testing of skin penetration using biotechnologically devised human skin equivalents. Phase 2: Validation- Details of Validation study for testing of skin penetration using biotechnologically devised human skin equivalents. Phase 2: Validation
• Evaluation of endpoints in addition to MTT for predicting skin irritation potential of chemical substances with in vitro human reconstructed skin models.- Details of Evaluation of endpoints in addition to MTT for predicting skin irritation potential of chemical substances with in vitro human reconstructed skin models.
• In vitro tests for photogenotoxicity assessment as alternatives to photocarcinogenicity tests in ro-dents (Project part 1).- Details of In vitro tests for photogenotoxicity assessment as alternatives to photocarcinogenicity tests in ro-dents (Project part 1).
• Action Programme Environment and Health. Project: Improvement of the /Recording of Human Exposure Data for the Quality Enhancement of the Monitoring System \'Cases of Poisoning Reported by Physicians under Section 16e of the German Chemicals Act- Details of Action Programme Environment and Health. Project: Improvement of the /Recording of Human Exposure Data for the Quality Enhancement of the Monitoring System \'Cases of Poisoning Reported by Physicians under Section 16e of the German Chemicals Act
• Determining the uptake of food additives by children and adolescents in Germany- Details of Determining the uptake of food additives by children and adolescents in Germany
• Determination of di-iso-butylphthalate (DiBP) and di-n-butylphthalate (DnBP) in paper and board packagings for infant formulae and in the packaged food- Details of Determination of di-iso-butylphthalate (DiBP) and di-n-butylphthalate (DnBP) in paper and board packagings for infant formulae and in the packaged food
• Investigation on the skin penetration and skin toxicity of polycyclic aromatic hydrocarbons- Details of Investigation on the skin penetration and skin toxicity of polycyclic aromatic hydrocarbons
• Plasticizing substances from food packaged in glass containers with metal lids - analytics and exposition- Details of Plasticizing substances from food packaged in glass containers with metal lids - analytics and exposition
• Investigation of metabolites of the tobacco specific nitrosamine NNK, acrylamide and acrolein in urine of smokers of waterpipes- Details of Investigation of metabolites of the tobacco specific nitrosamine NNK, acrylamide and acrolein in urine of smokers of waterpipes
• Quantification of the migration of polycyclic aromatic hydrocarbons (PAHs) from various consumer products at regular handling conditions- Details of Quantification of the migration of polycyclic aromatic hydrocarbons (PAHs) from various consumer products at regular handling conditions
• Development and evaluation of a method for the detection and quantification of volatile organic compounds (VOC) in consumer products- Details of Development and evaluation of a method for the detection and quantification of volatile organic compounds (VOC) in consumer products
• Mixtures of PAHs in consumer products – Toxicity in human keratinocytes- Details of Mixtures of PAHs in consumer products – Toxicity in human keratinocytes
• Development of an LC-MS/MS method for the determination of perfluorinated compounds (PFCs) like fluortelomer alcohols, perfluorinated carboxylates (e.g. PFOA) and sulfonates (e.g. PFOS)- Details of Development of an LC-MS/MS method for the determination of perfluorinated compounds (PFCs) like fluortelomer alcohols, perfluorinated carboxylates (e.g. PFOA) and sulfonates (e.g. PFOS)
• Investigation of mutagenicity in the smoke of waterpipes and cigarettes- Details of Investigation of mutagenicity in the smoke of waterpipes and cigarettes
• Investigations on the genotoxicity of formaldehyde in human cells in culture: Repair of DNA-protein crosslinks and identification of a \'threshold\' dose for carcinogenic activity- Details of Investigations on the genotoxicity of formaldehyde in human cells in culture: Repair of DNA-protein crosslinks and identification of a \'threshold\' dose for carcinogenic activity
• Studies on skin penetration of ingredients of cosmetics and commodities using in-vitro methods- Details of Studies on skin penetration of ingredients of cosmetics and commodities using in-vitro methods
• Activation of azo dyes to genotoxic metabolites by skin bacteria and studies for skin penetration- Details of Activation of azo dyes to genotoxic metabolites by skin bacteria and studies for skin penetration
• Nrf2-deficient human cell lines as a biological tool to screen for compounds of toxicological concern in consumer products.- Details of Nrf2-deficient human cell lines as a biological tool to screen for compounds of toxicological concern in consumer products.
• Investigation on migration of substances and substance mixtures from colored textiles- Details of Investigation on migration of substances and substance mixtures from colored textiles
• Studies on the allergenic potential ingredients of commedities and cosmetics using the local lymph node assay- Details of Studies on the allergenic potential ingredients of commedities and cosmetics using the local lymph node assay
• Mutagenicity and toxicity of water pipe smoke- Details of Mutagenicity and toxicity of water pipe smoke
• Proteomic analysis of oxidative stress after nanoparticle treatment in cell culture to study cytotoxicity mechanisms- Details of Proteomic analysis of oxidative stress after nanoparticle treatment in cell culture to study cytotoxicity mechanisms
• Development of a \'Contact Allergen Activated T-Cell (CAATC)-Assay\' using dendritic cells from skin: characterization of the sensitizing potency of chemicals via dendritic cell-induced expression of lineage specific T cell transcription factors- Details of Development of a \'Contact Allergen Activated T-Cell (CAATC)-Assay\' using dendritic cells from skin: characterization of the sensitizing potency of chemicals via dendritic cell-induced expression of lineage specific T cell transcription factors
• Cell cycle effects on the endocrine system and phase I metabolism- Details of Cell cycle effects on the endocrine system and phase I metabolism
• Metabolism of polyaromatic hydrocarbons by the microbiome of the skin- Details of Metabolism of polyaromatic hydrocarbons by the microbiome of the skin
• Proteomic analysis of cellular changes after treatment with contact allergens in human monocytic cell lines and in primary dendritic cells- Details of Proteomic analysis of cellular changes after treatment with contact allergens in human monocytic cell lines and in primary dendritic cells
• Examinations of poly- or perfluorinated compounds in food contact materials- Details of Examinations of poly- or perfluorinated compounds in food contact materials
• NanoGEM: Nanostructured Materials - Health, Exposition and Material Properties- Details of NanoGEM: Nanostructured Materials - Health, Exposition and Material Properties
• Examination and drafting of Summary Datasheets on toxicity data related to the evaluation by the CEF Panel of substances to be used in food contact materials- Details of Examination and drafting of Summary Datasheets on toxicity data related to the evaluation by the CEF Panel of substances to be used in food contact materials
• Development of an analytical, imaging method for the determination and localisation of nanoparticles in a cell line (THP-1 cells)- Details of Development of an analytical, imaging method for the determination and localisation of nanoparticles in a cell line (THP-1 cells)
• PERFOOD - Perfluorinated Compounds in our diet- Details of PERFOOD - Perfluorinated Compounds in our diet
• Method development for the characterisation and quantification of toxic volatile impurities from consumer goods, transported in fumigated shipping containers- Details of Method development for the characterisation and quantification of toxic volatile impurities from consumer goods, transported in fumigated shipping containers
• Characterization of metabolizing enzymes and biotransformation of selected test substances in human in-vitro skin models to identify an optimal test system for dermato-toxicological and exposure-related studies- Details of Characterization of metabolizing enzymes and biotransformation of selected test substances in human in-vitro skin models to identify an optimal test system for dermato-toxicological and exposure-related studies
• Public Information Tobacco Control (PITOC)- Details of Public Information Tobacco Control (PITOC)
• Method development for the identification of biomarkers for risk assessment of endocrine disruptors and phthalates- Details of Method development for the identification of biomarkers for risk assessment of endocrine disruptors and phthalates
• Characterization of cellular effects of contact sensitizers in vitro: Analysis of phosphotyrosine signaling pathways by far western blotting and establishment of a screening method- Details of Characterization of cellular effects of contact sensitizers in vitro: Analysis of phosphotyrosine signaling pathways by far western blotting and establishment of a screening method
• 2009: Skin Penetration of Substances from Consumer Products 2010: Combined Migration and Skin Permeation of Phthalates from Consumer Products- Details of 2009: Skin Penetration of Substances from Consumer Products 2010: Combined Migration and Skin Permeation of Phthalates from Consumer Products
• Development of a contact allergen-induced T-cell assay using Langerhans cells: 2009: Expression of lineage specific T-cell transcription factors as biological endpoint suitable to indicate chemical induction of sensitization 2010: Measurement and quantification of transcription factors via qRT-PCR and FACS- Details of Development of a contact allergen-induced T-cell assay using Langerhans cells: 2009: Expression of lineage specific T-cell transcription factors as biological endpoint suitable to indicate chemical induction of sensitization 2010: Measurement and quantification of transcription factors via qRT-PCR and FACS
• Expression analysis of drug-metabolizing enzymes in human keratinocytes after treatment with selected xenobiotics- Details of Expression analysis of drug-metabolizing enzymes in human keratinocytes after treatment with selected xenobiotics
• Identification of novel molecular biomarkers enabling reliable assessment of endocrine distruptor activity in-vitro- Details of Identification of novel molecular biomarkers enabling reliable assessment of endocrine distruptor activity in-vitro
• 2009: Development of a method suited to identify epigenetic effects in cells in culture upon exposure to low doses of model compounds, 2010: Investigation of epigenetic effects of consumer product-related model compounds in vitro- Details of 2009: Development of a method suited to identify epigenetic effects in cells in culture upon exposure to low doses of model compounds, 2010: Investigation of epigenetic effects of consumer product-related model compounds in vitro
• Qualitative and quantitative analysis of toxicological relevant matters in the mainstream smoke of the waterpipe- Details of Qualitative and quantitative analysis of toxicological relevant matters in the mainstream smoke of the waterpipe
• Scented toys: Exposure of infants against allergenic scents - Research on the analysis and biological effects of allergens in toys- Details of Scented toys: Exposure of infants against allergenic scents - Research on the analysis and biological effects of allergens in toys
• Chemical Imaging of Human Cells after Exposure to Metal Oxide Nanoparticles in vitro- Details of Chemical Imaging of Human Cells after Exposure to Metal Oxide Nanoparticles in vitro
• Investigation of cytotoxicity and genotoxicity of water pipe smoke- Details of Investigation of cytotoxicity and genotoxicity of water pipe smoke
• Genotoxicity testing in 3D model ? Establishment and adaptation of the COMET assay using a model for bronchial epithelia exposed to ingredients of consumer products- Details of Genotoxicity testing in 3D model ? Establishment and adaptation of the COMET assay using a model for bronchial epithelia exposed to ingredients of consumer products
• Proof of sensitization in human dendritic cells of the skin in a migration assay and induction of T cell response in in-vitro models without animal experiments- Details of Proof of sensitization in human dendritic cells of the skin in a migration assay and induction of T cell response in in-vitro models without animal experiments
• Advancement of toxicological study parameters in human cell cultures- Details of Advancement of toxicological study parameters in human cell cultures
• Establishment and development of gentoxicity testing methods - Setup of the COMET assay for ingedients of product- Details of Establishment and development of gentoxicity testing methods - Setup of the COMET assay for ingedients of product
• Investigations on metabolism of the skin with in vitro models- Details of Investigations on metabolism of the skin with in vitro models
• Determination of perfluorinated compounds in simulants for contact with fatty food (simulant D)- Details of Determination of perfluorinated compounds in simulants for contact with fatty food (simulant D)
• Expert toxicological assessment of smoke constituents (ETASC)- Details of Expert toxicological assessment of smoke constituents (ETASC)
• Skin penetration in vitro- Details of Skin penetration in vitro
• Production of textiles with defined composition and investigation of migrates- Details of Production of textiles with defined composition and investigation of migrates
• Screening assays for toxic and sensitizing substances in mixtures of azo dyes and its metabolites using human keratinocytes- Details of Screening assays for toxic and sensitizing substances in mixtures of azo dyes and its metabolites using human keratinocytes
• Expression of xenobiotic metabolizing cytochrome P450 (CYP)-dependent monooxygenases in human keratinocytes and permanent skin cell cultures- Details of Expression of xenobiotic metabolizing cytochrome P450 (CYP)-dependent monooxygenases in human keratinocytes and permanent skin cell cultures
• Inhibition of the transcription factor Nrf2 as a putative mechanism of toxicity exerted by compounds from dyes, glues and vulcanization accelerators in human keratinocytes (HaCaT)- Details of Inhibition of the transcription factor Nrf2 as a putative mechanism of toxicity exerted by compounds from dyes, glues and vulcanization accelerators in human keratinocytes (HaCaT)
• Studies on toxicity and genotoxicity of substances from commodities, e.g. azo dyes and vulcanisation aids- Details of Studies on toxicity and genotoxicity of substances from commodities, e.g. azo dyes and vulcanisation aids
• Development of methods for cleavage of azo dyes by human skin bacteria in vitro- Details of Development of methods for cleavage of azo dyes by human skin bacteria in vitro
• Development of screening assays for the assessment of the toxicity of migrants from commodities in keratinocytes- Details of Development of screening assays for the assessment of the toxicity of migrants from commodities in keratinocytes
• Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained.- Details of Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained.
• Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained- Details of Developing analytical, imaging method for the identification of nanoparticles in cell lines (THP1 cells) as well as the elucidation of the effects obtained
• Development and validation of a simple analytical method for quantification of mineral oil components MOSH and MOAH in foods based on conventional liquid chromatography and GC-FID- Details of Development and validation of a simple analytical method for quantification of mineral oil components MOSH and MOAH in foods based on conventional liquid chromatography and GC-FID
• Tattoo inks: chemical characterization and distribution in the human skin- Details of Tattoo inks: chemical characterization and distribution in the human skin
• The inflammatory milieu in human skin affected by chemical contact allergens- Details of The inflammatory milieu in human skin affected by chemical contact allergens
• Additives that increase addicitivness and attractivness of tobacco products- Details of Additives that increase addicitivness and attractivness of tobacco products
• Perfuoroalkyl and polyfluoroalkyl substances in breast milk: Contents, time trends, relevance of influencing factors including individual consumption patterns and assessment for the breast fed infant- Details of Perfuoroalkyl and polyfluoroalkyl substances in breast milk: Contents, time trends, relevance of influencing factors including individual consumption patterns and assessment for the breast fed infant
• Overweight and obesity in children, adolescents and young adults as a systemic risk- Details of Overweight and obesity in children, adolescents and young adults as a systemic risk
• Improvement of methods of evaluation of communication programs- Details of Improvement of methods of evaluation of communication programs
• Investigation of potential (risk) communication problems in the use of \'risk\' and \'hazard\' and derivation of recommendations for action- Details of Investigation of potential (risk) communication problems in the use of \'risk\' and \'hazard\' and derivation of recommendations for action
• Forming a global network for identifying food-related emerging risks (EmRisk)- Details of Forming a global network for identifying food-related emerging risks (EmRisk)
• SFB 852 Nutrition and intestinal microbiota ? host interaction in the pig (Collaborative research centre of the DFG)Individual Project A2: Influence of nutritional factors on the prevalence of viruses, including viruses with zoonotic potential, in faeces of clinically healthy pigs- Details of SFB 852 Nutrition and intestinal microbiota ? host interaction in the pig (Collaborative research centre of the DFG)Individual Project A2: Influence of nutritional factors on the prevalence of viruses, including viruses with zoonotic potential, in faeces of clinically healthy pigs
• Investigations of food (milk) for Listeria spp - Details of Investigations of food (milk) for Listeria spp
• Studies on the growth kinetics of Vibrio spp. in different matrices- Details of Studies on the growth kinetics of Vibrio spp. in different matrices
• Investigation of Shiga-toxin 2e (Stx2e) producing strains of Escherichia coli as potential human pathogenic bacteria and their significance as contaminants in the food chain- Details of Investigation of Shiga-toxin 2e (Stx2e) producing strains of Escherichia coli as potential human pathogenic bacteria and their significance as contaminants in the food chain
• Pilot study investigating Leptospira serovars in wild boars- Details of Pilot study investigating Leptospira serovars in wild boars
• Type IV secretion in Yersinia: Occurrence, molecular characterization and genotyping of Yersinia isolates harbouring a conjugative type IV system- Details of Type IV secretion in Yersinia: Occurrence, molecular characterization and genotyping of Yersinia isolates harbouring a conjugative type IV system
• Application of Bacteriophages for the Reduction of Campylobacter on Food- Details of Application of Bacteriophages for the Reduction of Campylobacter on Food
• Cost-benefit analysis of measures to reduce the prevalence of salmonella-serotyps in population of pigs for slaughter and the effect of determining maximum values for undesirable substances in animal nutrition- Details of Cost-benefit analysis of measures to reduce the prevalence of salmonella-serotyps in population of pigs for slaughter and the effect of determining maximum values for undesirable substances in animal nutrition
• FOR 438 Subproject G: Experimental studies on the effect of probiotics by means of challenge with pathogenic microorganisms- Details of FOR 438 Subproject G: Experimental studies on the effect of probiotics by means of challenge with pathogenic microorganisms
• Microbial stress response of Campylobacter jejuni and its role in food processing- Details of Microbial stress response of Campylobacter jejuni and its role in food processing
• Comparison of the specificity of a series of real-time methods for Campylobacter subsp. - Details of Comparison of the specificity of a series of real-time methods for Campylobacter subsp.
• Biofilm problem in meat processing using the example of Listeria monocytogenes- Details of Biofilm problem in meat processing using the example of Listeria monocytogenes
• Survival of Listeria monocytogenes in meat products - Details of Survival of Listeria monocytogenes in meat products
• Epidemiological study on routes of introduction of Salmonella infection into the food production chain for table eggs- Details of Epidemiological study on routes of introduction of Salmonella infection into the food production chain for table eggs
• Development of a rapid method to detect Campylobacter on poultry farms and at abattoirs- Details of Development of a rapid method to detect Campylobacter on poultry farms and at abattoirs
• Changes in properties by gene transfer agents (e.g. E. coli, Yersinia)- Details of Changes in properties by gene transfer agents (e.g. E. coli, Yersinia)
• Incidence and Characterization of Antibiotic Resistance Determinants in Salmonella Enteritidis Isolates from food and food-producing animals- Details of Incidence and Characterization of Antibiotic Resistance Determinants in Salmonella Enteritidis Isolates from food and food-producing animals
• Characterisation of the samples tested in selected official investigation centres (monitoring of antimicrobial resistance)- Details of Characterisation of the samples tested in selected official investigation centres (monitoring of antimicrobial resistance)
• Study on leptospirosis prevalence in dogs and humans- Details of Study on leptospirosis prevalence in dogs and humans
• Detection and characterization of noro- and rotaviruses of chicken as potential zoonotic food-borne pathogens- Details of Detection and characterization of noro- and rotaviruses of chicken as potential zoonotic food-borne pathogens
• Collaborative project: Application of bacteriophages for quantitative reduction of Campylobacter in broiler chickens – Subproject 1- Details of Collaborative project: Application of bacteriophages for quantitative reduction of Campylobacter in broiler chickens – Subproject 1
• Development, improvement and assessment of PCR methods for detection and subtyping of Yersinia- Details of Development, improvement and assessment of PCR methods for detection and subtyping of Yersinia
• Characterization of predatory bacteria from the gastrointestinal tract of domestic animals- Details of Characterization of predatory bacteria from the gastrointestinal tract of domestic animals
• Risk potential determination of Salmonella Paratyphi B dT+ strains for animals and humans- Details of Risk potential determination of Salmonella Paratyphi B dT+ strains for animals and humans
• Second Generation Subtyping within the European Network PulseNet Europe: Development and Validation of a Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA) System for Non-O157 Shiga Toxin-Producing Escherichia coli- Details of Second Generation Subtyping within the European Network PulseNet Europe: Development and Validation of a Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA) System for Non-O157 Shiga Toxin-Producing Escherichia coli
• Characterisation of Salmonella Paratyphi B dT+ strains by phage typing- Details of Characterisation of Salmonella Paratyphi B dT+ strains by phage typing
• Long-term study in pigs infected with salmonella- Details of Long-term study in pigs infected with salmonella
• Safe pork and horse meat on EU-markets: early and unbiased diagnostic tests for Trichinella (TRICHOPORSE)- Details of Safe pork and horse meat on EU-markets: early and unbiased diagnostic tests for Trichinella (TRICHOPORSE)
• Network for Prevention and Control of Zoonoses (Med-Vet-Net)- Details of Network for Prevention and Control of Zoonoses (Med-Vet-Net)
• Promoting Food safety through a New Integrated Risk Analysis Approach for Foods (SAFE FOODS)- Details of Promoting Food safety through a New Integrated Risk Analysis Approach for Foods (SAFE FOODS)
• Application of geographical information systems, GIS, for the analysis of epidemiological data- Details of Application of geographical information systems, GIS, for the analysis of epidemiological data
• Development of a Variable-Number-Tandem-Repeat Analysis (MLVA) typing system for Salmonella Enteritidis isolates- Details of Development of a Variable-Number-Tandem-Repeat Analysis (MLVA) typing system for Salmonella Enteritidis isolates
• Investigation of occurrence, types and human pathogenicity of Shiga- toxin producing Escherichia coli (STEC) in meat samples from wild-life animals as a basis for risk assessment- Details of Investigation of occurrence, types and human pathogenicity of Shiga- toxin producing Escherichia coli (STEC) in meat samples from wild-life animals as a basis for risk assessment
• Microbial stress response of Campylobacter jejuni and its role in food processing- Details of Microbial stress response of Campylobacter jejuni and its role in food processing
• Carry over of nasal Methicillin resistant S. aureus (MRSA) on the carcass of slaughter pigs at the abbatoir- Details of Carry over of nasal Methicillin resistant S. aureus (MRSA) on the carcass of slaughter pigs at the abbatoir
• Quantitative and qualitative detection of foodborne pathogens using real-time PCR and typing of the pathogens with DNA microarray- Details of Quantitative and qualitative detection of foodborne pathogens using real-time PCR and typing of the pathogens with DNA microarray
• Support of the national broiler campylobacter monitoring- Details of Support of the national broiler campylobacter monitoring
• Detection of Norovirus in clinical samples of human provenience, in environmental and food samples to investigate virus transmission routes- Details of Detection of Norovirus in clinical samples of human provenience, in environmental and food samples to investigate virus transmission routes
• Collection of data fort he risk assessment on Salmonella in table eggs- Details of Collection of data fort he risk assessment on Salmonella in table eggs
• Prevalence and diversity among temperate bacteriophages (prophages) in the genome of methicillin-resistent staphylococcus aureus (MRSA) isolates from the food-chain- Details of Prevalence and diversity among temperate bacteriophages (prophages) in the genome of methicillin-resistent staphylococcus aureus (MRSA) isolates from the food-chain
• Molecular Risk Assessment of Shiga Toxin producing E. coli (STEC) from food and of attaching and effacing E. coli (AEEC) in regard to their human virulence and as a reservoir of new emerging enterohaemorrhagic E. coli types.- Details of Molecular Risk Assessment of Shiga Toxin producing E. coli (STEC) from food and of attaching and effacing E. coli (AEEC) in regard to their human virulence and as a reservoir of new emerging enterohaemorrhagic E. coli types.
• Multiplex real-time PCR rapid method for serovar-typing and quantification of salmonellae- Details of Multiplex real-time PCR rapid method for serovar-typing and quantification of salmonellae
• MALDI-TOF MS-based identification of microorganisms from complex samples- Details of MALDI-TOF MS-based identification of microorganisms from complex samples
• Toxin production of Vibrio spp.- Details of Toxin production of Vibrio spp.
• Application of bacteriophages for the detection and isolation of pathogenic Y. enterocolitica strains in food- Details of Application of bacteriophages for the detection and isolation of pathogenic Y. enterocolitica strains in food
• Investigation of food products illegally introduced into Germany by airport luggage for the presence of the non-endemic pathogens Brucella and (\'2010:Trichinella\').- Details of Investigation of food products illegally introduced into Germany by airport luggage for the presence of the non-endemic pathogens Brucella and (\'2010:Trichinella\').
• 2010: Development and validation of an ELISA for the detection of Leptospira infection- Details of 2010: Development and validation of an ELISA for the detection of Leptospira infection
• Characterization of biofilm formation by Listeria monocytogenes- Details of Characterization of biofilm formation by Listeria monocytogenes
• Generation of norovirus-like particles as antigen for the development of detection systems for viruses in food- Details of Generation of norovirus-like particles as antigen for the development of detection systems for viruses in food
• Development of a Variable-Number Tandem-Repeats (VNTR) analysis method for the subtyping of Salmonella enterica serovar Infantis und Virchow- Details of Development of a Variable-Number Tandem-Repeats (VNTR) analysis method for the subtyping of Salmonella enterica serovar Infantis und Virchow
• Induction and expression of Shiga Toxins in STEC and EHEC strains for their diagnosis and as parameter for risk assessment- Details of Induction and expression of Shiga Toxins in STEC and EHEC strains for their diagnosis and as parameter for risk assessment
• Methicillin resistant and enterotoxic S. aureus in raw milk from dairy cows- Details of Methicillin resistant and enterotoxic S. aureus in raw milk from dairy cows
• Detection of non-coli/jejuni Campylobacter species in different food matrices- Details of Detection of non-coli/jejuni Campylobacter species in different food matrices
• Detection of Viruses in Food using \'Molecularly Imprinted Polymers\'- Details of Detection of Viruses in Food using \'Molecularly Imprinted Polymers\'
• Mass spectrometric characterisation/identification of microbial pathogens of Vibrio spp. \'2010: Yersinia enterocolitica\'- Details of Mass spectrometric characterisation/identification of microbial pathogens of Vibrio spp. \'2010: Yersinia enterocolitica\'
• Development and validation of a Trichinella Western Blot for for the certification of pigs from fattening farms- Details of Development and validation of a Trichinella Western Blot for for the certification of pigs from fattening farms
• Isolation and characterization of the origin of transfer (oriT) of the Yersinia virulence plasmid pYV- Details of Isolation and characterization of the origin of transfer (oriT) of the Yersinia virulence plasmid pYV
• Evaluation of production methods for salami type sausages in the framework of risk assessment to evaluate the survival or growth of pathogens and the possible mycotoxin burdden of mould ripened sausages- Details of Evaluation of production methods for salami type sausages in the framework of risk assessment to evaluate the survival or growth of pathogens and the possible mycotoxin burdden of mould ripened sausages
• Storage of deep frozen meat with special regard to human health and quality aspects- Details of Storage of deep frozen meat with special regard to human health and quality aspects
• Risk assessment for evaluation of STEC contamination in food- Details of Risk assessment for evaluation of STEC contamination in food
• Detection of Bacillus cereus toxins- Details of Detection of Bacillus cereus toxins
• Investigation on contamination of raw consumed food of vegetable origin with VTEC / STEC / EHEC using serological and molecular detection methods- Details of Investigation on contamination of raw consumed food of vegetable origin with VTEC / STEC / EHEC using serological and molecular detection methods
• Characterization of Methicillin-resistent Staphylococcus aureus (MRSA) - isolates in respect of the presence of enterotoxin producing genes- Details of Characterization of Methicillin-resistent Staphylococcus aureus (MRSA) - isolates in respect of the presence of enterotoxin producing genes
• Harmonisation of methods for the monitoring of VTEC and subtyping of stx2 genes- Details of Harmonisation of methods for the monitoring of VTEC and subtyping of stx2 genes
• Rat hepatitis E virus as a model virus for studies on stability, pathogenicity and transmission pathways of human hepatitis E viruses- Details of Rat hepatitis E virus as a model virus for studies on stability, pathogenicity and transmission pathways of human hepatitis E viruses
• Characterisation of Campylobacter lari strains- Details of Characterisation of Campylobacter lari strains
• Studies on the occurrence of infections with pathogens of the Mycobacterium avium-intracellulare complex (mycobacteriosis) in slaughter pigs- Details of Studies on the occurrence of infections with pathogens of the Mycobacterium avium-intracellulare complex (mycobacteriosis) in slaughter pigs
• Behaviour of micro flora and pathogens following decontamination of poultry carcasses- Details of Behaviour of micro flora and pathogens following decontamination of poultry carcasses
• Identification of marker genes for important Listeria monocytogenes serotypes as a basis for the development of rapid molecular methods- Details of Identification of marker genes for important Listeria monocytogenes serotypes as a basis for the development of rapid molecular methods
• Molecular epidemiology of MRSA from livestock ? detailed characterization and typing of isolates for the deduction of epidemiological correlations- Details of Molecular epidemiology of MRSA from livestock ? detailed characterization and typing of isolates for the deduction of epidemiological correlations
• Molecular typing as an alternative method for the serological determination of flagellar antigens in E. coli- Details of Molecular typing as an alternative method for the serological determination of flagellar antigens in E. coli
• Importance of new emerging serogroups of STEC / EHEC as contaminants of foodstuffs and potential pathogens of humans in Germany- Details of Importance of new emerging serogroups of STEC / EHEC as contaminants of foodstuffs and potential pathogens of humans in Germany
• Analysis of the variability of antibiotic resistance profiles in Campylobacter- Details of Analysis of the variability of antibiotic resistance profiles in Campylobacter
• Molecular subtyping of Listeria monocytogenes using pulsed-field gel electrophoresis (PFGE)- Details of Molecular subtyping of Listeria monocytogenes using pulsed-field gel electrophoresis (PFGE)
• Mobile genetic elements of Brucella - bacteriophages- Details of Mobile genetic elements of Brucella - bacteriophages
• Temperate phages of Campylobacter jejuni- Details of Temperate phages of Campylobacter jejuni
• Genetic investigation of rough Salmonella Enteritidis strains- Details of Genetic investigation of rough Salmonella Enteritidis strains
• Testing of Salmonella and E. coli isolates from pigs concerning their copper and zinc resistance- Details of Testing of Salmonella and E. coli isolates from pigs concerning their copper and zinc resistance
• Molecular detection of the highly pathogenic zoonotic agent Brucella in cheese samples originating from endemic countries.- Details of Molecular detection of the highly pathogenic zoonotic agent Brucella in cheese samples originating from endemic countries.
• Metabolic activity in raw milk-biofilms with Listeria monocytogenes after a sub-optimal clean-ing with hydrogen peroxide- Details of Metabolic activity in raw milk-biofilms with Listeria monocytogenes after a sub-optimal clean-ing with hydrogen peroxide
• Development of a Real-Time PCR system for identification and typing of bacteria be-longing to the ?Cereus- Group? from food.- Details of Development of a Real-Time PCR system for identification and typing of bacteria be-longing to the ?Cereus- Group? from food.
• Analysis of the migration of elastomers from food contact materials- Details of Analysis of the migration of elastomers from food contact materials
• Multiplex-Real-Time PCR based rapid method for serovar typing and quantification of salmonellae- Details of Multiplex-Real-Time PCR based rapid method for serovar typing and quantification of salmonellae
• Scientific and technical assistance relating to collection, reporting, compilation and analyses of data on food-borne outbreaks- Details of Scientific and technical assistance relating to collection, reporting, compilation and analyses of data on food-borne outbreaks
• Improved bio-traceability of unintended micro-organisms and their substances in food and feed chains (Biotracer)- Details of Improved bio-traceability of unintended micro-organisms and their substances in food and feed chains (Biotracer)
• Interdisciplinary Research Network (MedVetStaph)IP3 - MRSA in the food chain: Source attribution and transmission modelling based on molecularcharacterization of isolates from the food chain and from humans- Details of Interdisciplinary Research Network (MedVetStaph)IP3 - MRSA in the food chain: Source attribution and transmission modelling based on molecularcharacterization of isolates from the food chain and from humans
• Collaborative project ESBL- and (fluoro-)quinolone resitance in enterobactericeae (RESET). Project IP1 characterization of newly emerging mechanisms for transfer of resistance to ß-lactam antibiotics with extended spectrum (ESBLs) and (fluoro) quinolones in German-Salmonella enterica and Escherichia coli isolates from healthy poultry and pigs and products thereof- Details of Collaborative project ESBL- and (fluoro-)quinolone resitance in enterobactericeae (RESET). Project IP1 characterization of newly emerging mechanisms for transfer of resistance to ß-lactam antibiotics with extended spectrum (ESBLs) and (fluoro) quinolones in German-Salmonella enterica and Escherichia coli isolates from healthy poultry and pigs and products thereof
• The role of commensal microflora of animals in the transmission of extended spectrum ß-lactamases (ESBLs)- Details of The role of commensal microflora of animals in the transmission of extended spectrum ß-lactamases (ESBLs)
• Analysis of cell wall structures of predatory bacteria and characterization of proteomic changes during the life cycle- Details of Analysis of cell wall structures of predatory bacteria and characterization of proteomic changes during the life cycle
• Campylobacter and E. coli ? a network project (CampEc-NET)- Details of Campylobacter and E. coli ? a network project (CampEc-NET)
• Experimental studies on the effect of probiotics by means of challenge with pathogenic microorganisms- Details of Experimental studies on the effect of probiotics by means of challenge with pathogenic microorganisms
• Epidemiological studies as the basis for the risk assessment of agroterroristically relevant pathogens- Details of Epidemiological studies as the basis for the risk assessment of agroterroristically relevant pathogens
• Development of harmonised schemes for monitoring and reporting of Echinococcus, Trichinella, Cysticercus and Sarcocystis in animals and foodstuffs in the EU (EFSA/Zoonoses/2007/01)- Details of Development of harmonised schemes for monitoring and reporting of Echinococcus, Trichinella, Cysticercus and Sarcocystis in animals and foodstuffs in the EU (EFSA/Zoonoses/2007/01)
• Development of harmonised survey methods for foodborne pathogens in foodstuffs in the European Union (CFP/EFSA/Zoonoses/2008/2)- Details of Development of harmonised survey methods for foodborne pathogens in foodstuffs in the European Union (CFP/EFSA/Zoonoses/2008/2)
• Hazard identification of Salmonella in the food chain (Subroject IP3 within the joint project Food-Borne Zoonotic Infections of Humans (FBI-Zoo))- Details of Hazard identification of Salmonella in the food chain (Subroject IP3 within the joint project Food-Borne Zoonotic Infections of Humans (FBI-Zoo))
• Integrated project: Epidemiological research network: Foodborne Infections in Germany; Project: Quantitative Risk Assessment fo human Campylobacter infections due to consumption of chicken meat- Details of Integrated project: Epidemiological research network: Foodborne Infections in Germany; Project: Quantitative Risk Assessment fo human Campylobacter infections due to consumption of chicken meat
• Collaborative Project: Development of innovative process integrated microbiological stage control systems for the reduction of Campylobacter spp. and Salmonella spp. in meat production - Subproject 2- Details of Collaborative Project: Development of innovative process integrated microbiological stage control systems for the reduction of Campylobacter spp. and Salmonella spp. in meat production - Subproject 2
• Molecular characterization of porcine Campylobacter (C.) coli population. Extension of data situation as a precondition for the creation of risk assessment for C. coli- Details of Molecular characterization of porcine Campylobacter (C.) coli population. Extension of data situation as a precondition for the creation of risk assessment for C. coli
• Infection kinetics and host specificity of methicillin-resistant Staphylococcus aureus (MRSA) in the pig- Details of Infection kinetics and host specificity of methicillin-resistant Staphylococcus aureus (MRSA) in the pig
• Development of a method applicable to § 64 LFGB for the detection and isolation of enterohaemorrhagic E. coli (EHEC) from plant foods- Details of Development of a method applicable to § 64 LFGB for the detection and isolation of enterohaemorrhagic E. coli (EHEC) from plant foods
• VetCAb: Representative collection of consumption amounts of antibiotics in food-producing animals. Conception and preparation of a pilot study- Details of VetCAb: Representative collection of consumption amounts of antibiotics in food-producing animals. Conception and preparation of a pilot study
• Validation of the BfR in-house ELISA for the detection of Leptospira infection originating from foreign countries- Details of Validation of the BfR in-house ELISA for the detection of Leptospira infection originating from foreign countries
• Uptake and cellular localization of nano particles in enterocytes- Details of Uptake and cellular localization of nano particles in enterocytes
• Investigation of the consumer exposure with residues of perfluorinated tensides (PFT) occurring in fresh-water fish- Details of Investigation of the consumer exposure with residues of perfluorinated tensides (PFT) occurring in fresh-water fish
• Investigation of uptake, accumulation and distribution of malachite green in aquacultured fish- Details of Investigation of uptake, accumulation and distribution of malachite green in aquacultured fish
• Determination of the exposition of consumers with residues of malachite green and leucomalachite green from eels accounting for the background contamination in aquatic systems- Details of Determination of the exposition of consumers with residues of malachite green and leucomalachite green from eels accounting for the background contamination in aquatic systems
• Levels of dioxin and dioxin-like PCBs in cod liver and the corresponding cod muscle meat from different fishing areas of the Baltic Sea and North Atlantic- Details of Levels of dioxin and dioxin-like PCBs in cod liver and the corresponding cod muscle meat from different fishing areas of the Baltic Sea and North Atlantic
• Use of hepatic in vitro systems for detection of liver carcinogens by application of toxicogenomics- Details of Use of hepatic in vitro systems for detection of liver carcinogens by application of toxicogenomics
• Identification of proteomic biomarkers in human after exposure to furan fatty acids- Details of Identification of proteomic biomarkers in human after exposure to furan fatty acids
• Impact of the carbon chain length of perfluor carbonic acids toxicity and molecular charac-terisation of the hepatotoxic effects of PFOA on the proteomic level- Details of Impact of the carbon chain length of perfluor carbonic acids toxicity and molecular charac-terisation of the hepatotoxic effects of PFOA on the proteomic level
• Identification of proteins from spots of gel electrophoresis using mass spectrometry- Details of Identification of proteins from spots of gel electrophoresis using mass spectrometry
• Determination of the origin of hormones in cattle by Isotope Ratio Mass Spectrometry (ISOSTER- Details of Determination of the origin of hormones in cattle by Isotope Ratio Mass Spectrometry (ISOSTER
• Hydrolysis of flavouring substances- Details of Hydrolysis of flavouring substances
• Genotoxicity of flavouring substances- Details of Genotoxicity of flavouring substances
• Development of sample clean-up procedures preparing GC-C-IRMS measuremens of residues and contaminants in food- Details of Development of sample clean-up procedures preparing GC-C-IRMS measuremens of residues and contaminants in food
• Determination of the bovine somatotropin using HPLC and mass spectrometry- Details of Determination of the bovine somatotropin using HPLC and mass spectrometry
• Comparison of the allergenic potential of produce of plant origin derived from organic farming with plant produce derived from conventional farming- Details of Comparison of the allergenic potential of produce of plant origin derived from organic farming with plant produce derived from conventional farming
• Investigation of the origin of nortestosterone in different animals- Details of Investigation of the origin of nortestosterone in different animals
• Elaboration of an analytical method for the determination of residues of hexogene and other explosives in fish- Details of Elaboration of an analytical method for the determination of residues of hexogene and other explosives in fish
• Development of clean-up procedures for food samples as preparation of GC/C/IRMS measurements- Details of Development of clean-up procedures for food samples as preparation of GC/C/IRMS measurements
• Preparation of Reference Material for the Performance of Proficiency Tests to achieve the Purpose of the Detection of Marine Biotoxins- Details of Preparation of Reference Material for the Performance of Proficiency Tests to achieve the Purpose of the Detection of Marine Biotoxins
• Development of a Method for the Detection/Determination of Ciguatoxins- Details of Development of a Method for the Detection/Determination of Ciguatoxins
• New approaches to the study of food security on the basis of cell culture systems: development of a cell culture model to evaluate the influence of dietary factors on gene expression in colon cells by the example of fatty acids - Details of New approaches to the study of food security on the basis of cell culture systems: development of a cell culture model to evaluate the influence of dietary factors on gene expression in colon cells by the example of fatty acids
• Absorption and safety of nanoscale phytosterol formulations- Details of Absorption and safety of nanoscale phytosterol formulations
• Effect of plant sterols star on the protein pattern in blood mononuclear cells of healthy women - Details of Effect of plant sterols star on the protein pattern in blood mononuclear cells of healthy women
• Determination of heterocyclic aromatic amines in food - Details of Determination of heterocyclic aromatic amines in food
• Determination of pyrrolizidine alkaloids in honey - Details of Determination of pyrrolizidine alkaloids in honey
• Determining the origin of the growth hormone with isotope ratio monitoring LC / MS (irm-LC/MS)- Details of Determining the origin of the growth hormone with isotope ratio monitoring LC / MS (irm-LC/MS)
• Development of calibration standards for qualitative and quantitative detection of genetically modified ingredients under Regulation (EC) No 1829/2003 - Details of Development of calibration standards for qualitative and quantitative detection of genetically modified ingredients under Regulation (EC) No 1829/2003
• Evidence of a possible formation of benzene from benzoic acid in beverages- Details of Evidence of a possible formation of benzene from benzoic acid in beverages
• Carry over of DNA from genetically modified feed in tissue of farm animals: long-term study in quail over fifteen generations- Details of Carry over of DNA from genetically modified feed in tissue of farm animals: long-term study in quail over fifteen generations
• Pre- and postnatal exposure of mothers and children with perfluorinated substances- Details of Pre- and postnatal exposure of mothers and children with perfluorinated substances
• Determination of furan fatty acids and conjugated linoleic acids in food- Details of Determination of furan fatty acids and conjugated linoleic acids in food
• Differential expression of glutathione-S-transferases in Caco-2 cell line as indicator of the effects of phytochemicals- Details of Differential expression of glutathione-S-transferases in Caco-2 cell line as indicator of the effects of phytochemicals
• Differentiation of herring, cod and flounder populations from different fishing grounds of the Baltic Sea and the North Atlantic by DNA-analysis- Details of Differentiation of herring, cod and flounder populations from different fishing grounds of the Baltic Sea and the North Atlantic by DNA-analysis
• Elaboration of prerequisites for an expertise about the exposition of consumers with fusarium toxins- Details of Elaboration of prerequisites for an expertise about the exposition of consumers with fusarium toxins
• GM and non-GM supply chains: their CO-Existence and Traceability (Co-Extra)- Details of GM and non-GM supply chains: their CO-Existence and Traceability (Co-Extra)
• Development of analytical methods and evaluation of the consumer‘s risk by furan and similar toxicants- Details of Development of analytical methods and evaluation of the consumer‘s risk by furan and similar toxicants
• Determination of pyrrolizidin alkaloids in milk and milk products – Carry Over Study- Details of Determination of pyrrolizidin alkaloids in milk and milk products – Carry Over Study
• Transfer of iodine from teat disinfectants on teat skin and teat canal- Details of Transfer of iodine from teat disinfectants on teat skin and teat canal
• Content of dioxins and dioxin like PCBs in cod liver and corresponding cod muscle from different fishing grounds of the Baltic Sea and the North Atlantic- Details of Content of dioxins and dioxin like PCBs in cod liver and corresponding cod muscle from different fishing grounds of the Baltic Sea and the North Atlantic
• Project on the investigation of raw mass/material fluxes of animal fats as well as fat products which (could) be used in animal feeding: Origin, extraction and applications of animal fats with specific considerations of the hygienic aspects for foodstuff- Details of Project on the investigation of raw mass/material fluxes of animal fats as well as fat products which (could) be used in animal feeding: Origin, extraction and applications of animal fats with specific considerations of the hygienic aspects for foodstuff
• Development of a qualitative detection method for foods/feeds derived from gene technology – elimination of the PCR step as the \'bottleneck\' of the detection procedure- Details of Development of a qualitative detection method for foods/feeds derived from gene technology – elimination of the PCR step as the \'bottleneck\' of the detection procedure
• Studies on the metabolism of azo dyes in clothing textiles and cosmetics: Evidence of azo cleavage by skin bacteria and characterization of metabolites- Details of Studies on the metabolism of azo dyes in clothing textiles and cosmetics: Evidence of azo cleavage by skin bacteria and characterization of metabolites
• Development of NMR-methods for quantification of wine compounds- Details of Development of NMR-methods for quantification of wine compounds
• Using NMR-spectroscopy for wine authenticity tests- Details of Using NMR-spectroscopy for wine authenticity tests
• The influence of different kinds of Barrique wine production on the content of polycyclic hydrocarbons in wine- Details of The influence of different kinds of Barrique wine production on the content of polycyclic hydrocarbons in wine
• Evaluating the impact of treatment using pulsed electric fields - Details of Evaluating the impact of treatment using pulsed electric fields
• Identification and assessment of potential risks in the course of production or manufacturing processes for food that can lead to a potential accumulation of residues of contaminants or undesirable substances in co- or by-products- Details of Identification and assessment of potential risks in the course of production or manufacturing processes for food that can lead to a potential accumulation of residues of contaminants or undesirable substances in co- or by-products
• Molecularkinetic characterization of the transport and the distribution of the pro-carcinogene Benzo[a]pyrene in vitro and in vivo ? new kinetic data for risk assessment- Details of Molecularkinetic characterization of the transport and the distribution of the pro-carcinogene Benzo[a]pyrene in vitro and in vivo ? new kinetic data for risk assessment
• Analysis and occurrence of important fusarium toxins (deoxynivalenol, zearalenone) as well as intake of these toxins by the German consumer- Details of Analysis and occurrence of important fusarium toxins (deoxynivalenol, zearalenone) as well as intake of these toxins by the German consumer
• Breastfeeding behaviour of women after delivery in Berlin hospitals- Details of Breastfeeding behaviour of women after delivery in Berlin hospitals
• Development of methods for the determination of ergot alkaloids including monitoring in food and feed- Details of Development of methods for the determination of ergot alkaloids including monitoring in food and feed
• Masked mycotoxins: Exposition of the German consumer by Zearalenone-glycosides in food- Details of Masked mycotoxins: Exposition of the German consumer by Zearalenone-glycosides in food
• Collaborative project: Development of innovative rapid test and screening methods for on-site detection of food-borne allergens in product development and control – Subproject 1- Details of Collaborative project: Development of innovative rapid test and screening methods for on-site detection of food-borne allergens in product development and control – Subproject 1
• Molecular characterization of the interaction between perfluoroctanoic acid (PFOA) and the hepatocyte nuclear factor 4alpha (HNF4alpha)- Details of Molecular characterization of the interaction between perfluoroctanoic acid (PFOA) and the hepatocyte nuclear factor 4alpha (HNF4alpha)
• Gene expression profiling to elucidate the cancerogenic effects of breakdown products of 1-Methoxyindol-3-methylglucosinolates (MIM-GL) from Brassica vegetables- Details of Gene expression profiling to elucidate the cancerogenic effects of breakdown products of 1-Methoxyindol-3-methylglucosinolates (MIM-GL) from Brassica vegetables
• Haemoglobin adducts of glycidol as marker of exposure of glycidol fatty acid esters:Development of methods and human trial- Details of Haemoglobin adducts of glycidol as marker of exposure of glycidol fatty acid esters:Development of methods and human trial
• Bioavailability of cyanide from marzipan (human study)- Details of Bioavailability of cyanide from marzipan (human study)
• Influence of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) on the intestinal toxicity of silver nanoparticles- Details of Influence of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) on the intestinal toxicity of silver nanoparticles
• Analysis of effects from trans-fatty acids on miRNA expression profiles of human colon cells- Details of Analysis of effects from trans-fatty acids on miRNA expression profiles of human colon cells
• Interaction between metabolism and transport of toxicologically relevant compounds in the gastrointestinal barrier- Details of Interaction between metabolism and transport of toxicologically relevant compounds in the gastrointestinal barrier
• Reporter gene assays in permanent cell lines as screening tools for the detection of food contaminants- Details of Reporter gene assays in permanent cell lines as screening tools for the detection of food contaminants
• Proteomic analysis into molecular toxicological effects of nano particles in human intestinal Caco-2 cells- Details of Proteomic analysis into molecular toxicological effects of nano particles in human intestinal Caco-2 cells
• Proteomic analysis of effects induced by 3-MCPD and 3-MCPD fatty acid esters in rat liver and kidney- Details of Proteomic analysis of effects induced by 3-MCPD and 3-MCPD fatty acid esters in rat liver and kidney
• Influence of endocrine disruptors using the example of soy isoflavones on the transformationof multipotent progenitor cells of the human mammary epithelium- Details of Influence of endocrine disruptors using the example of soy isoflavones on the transformationof multipotent progenitor cells of the human mammary epithelium
• Development of a hepatic in vitro test system for the sensitive detection of pyrrolizidine alka-loids- Details of Development of a hepatic in vitro test system for the sensitive detection of pyrrolizidine alka-loids
• Proteomic investigations of carcinogenic effects in primary rat hepatocytes: prevalidation of an in vitro hepatic model for detection of non-genotoxic carcinogens- Details of Proteomic investigations of carcinogenic effects in primary rat hepatocytes: prevalidation of an in vitro hepatic model for detection of non-genotoxic carcinogens
• Marine Biotoxins: Analysis of the toxic effects of okadaic acid metabolites. Follow-up of Development of an in-vitro screening test of marine toxins based on embryonic stem cells- Details of Marine Biotoxins: Analysis of the toxic effects of okadaic acid metabolites. Follow-up of Development of an in-vitro screening test of marine toxins based on embryonic stem cells
• Dietary trans-fatty acids: Role of nuclear receptors in risk evaluation of trans-fatty acids with regard to their effects in colorectal cancer- Details of Dietary trans-fatty acids: Role of nuclear receptors in risk evaluation of trans-fatty acids with regard to their effects in colorectal cancer
• Bioavailability of 3-MCPD and 3-MCPD fatty acid esters- Details of Bioavailability of 3-MCPD and 3-MCPD fatty acid esters
• Development of new methods for the identification of animal proteins in feedingstuff. Real-time immuno-PCR for the detection of animal bone and tissue marker 2010: Validation of an immunological method for the detection of Osteocalcin representing a stable bone tissue marker in Meat and Bone Meal (MBM)- Details of Development of new methods for the identification of animal proteins in feedingstuff. Real-time immuno-PCR for the detection of animal bone and tissue marker 2010: Validation of an immunological method for the detection of Osteocalcin representing a stable bone tissue marker in Meat and Bone Meal (MBM)
• Molecular Toxicity of conjugated linoleic acid isomers and branched chain fatty acids; The role of the nuclear receptor PPAR in colon carcinogenesis- Details of Molecular Toxicity of conjugated linoleic acid isomers and branched chain fatty acids; The role of the nuclear receptor PPAR in colon carcinogenesis
• Molecular mechanisms of furan-mediated liver toxicity- Details of Molecular mechanisms of furan-mediated liver toxicity
• Bioavailability of coumarin from cinnamon and cinnamon-containing food (human study)- Details of Bioavailability of coumarin from cinnamon and cinnamon-containing food (human study)
• Analysis of commercial Isoflavone Supplements- Details of Analysis of commercial Isoflavone Supplements
• Analysis of commercial Isoflavone Supplements- Details of Analysis of commercial Isoflavone Supplements
• The influence of different acrylamide concentrations on the transcription of selected genes in cell cultures analyzed by microarrays. Analysis of the biofunctionality of acrylamide- Details of The influence of different acrylamide concentrations on the transcription of selected genes in cell cultures analyzed by microarrays. Analysis of the biofunctionality of acrylamide
• Interaction between metabolism and transport of toxicological relevant compounds in the gastrointestinal barrier- Details of Interaction between metabolism and transport of toxicological relevant compounds in the gastrointestinal barrier
• Effects of different dietary Se-sources for cows on Se-bioavailability from their milk- Details of Effects of different dietary Se-sources for cows on Se-bioavailability from their milk
• Investigations on the use of phytogenic feed additives in animal nutrition- Details of Investigations on the use of phytogenic feed additives in animal nutrition
• Investigation of the residue behavior of different antibiotics in aqua-cultured shrimps- Details of Investigation of the residue behavior of different antibiotics in aqua-cultured shrimps
• Effect of folate oversupplementation on the proliferation and the expression of relevant genes in colon carcinoma cells- Details of Effect of folate oversupplementation on the proliferation and the expression of relevant genes in colon carcinoma cells
• Determination of the isomerization and oxidation products from long-chain, polyunsaturated conjugated fatty acids in novel oils from the marine micro-alga- Details of Determination of the isomerization and oxidation products from long-chain, polyunsaturated conjugated fatty acids in novel oils from the marine micro-alga
• Detection of Allergens in food: a comparative study on DNA-analytical and immunological methods- Details of Detection of Allergens in food: a comparative study on DNA-analytical and immunological methods
• Investigations in vitro on structure-activity-relationship with respect to a teratogenic potential of flavouring substances- Details of Investigations in vitro on structure-activity-relationship with respect to a teratogenic potential of flavouring substances
• Identification of new molecular proteomic biomarker for the risk assessment of food related compounds; heat-tox products as important example (furan fatty acids and 3-MCPD)- Details of Identification of new molecular proteomic biomarker for the risk assessment of food related compounds; heat-tox products as important example (furan fatty acids and 3-MCPD)
• Joint project: Extraction and characterization of oligogalacturonic acids as well as research on the inhibition of attachment of pathogenic germs and cytotoxins to intestinal cells by means of in vitro test systems- Details of Joint project: Extraction and characterization of oligogalacturonic acids as well as research on the inhibition of attachment of pathogenic germs and cytotoxins to intestinal cells by means of in vitro test systems
• GM (genetically modified) and non-GM supply chains: their co-existence and traceability (Co-Extra)- Details of GM (genetically modified) and non-GM supply chains: their co-existence and traceability (Co-Extra)
• TRACE: Delivering Integrated Traceability Systems that will enhance Consumer Confidence in the Authenticity of Food- Details of TRACE: Delivering Integrated Traceability Systems that will enhance Consumer Confidence in the Authenticity of Food
• Determination of coumarin in different food samples- Details of Determination of coumarin in different food samples
• Effects of High Pressure Treatment on fat and pathogens- Details of Effects of High Pressure Treatment on fat and pathogens
• Establishing of a wine data bank for analytical parameters for wines from Third Countries (WINE DB)- Details of Establishing of a wine data bank for analytical parameters for wines from Third Countries (WINE DB)
• Maximum levels of contaminants in commercial fod intended for infants and young children- Details of Maximum levels of contaminants in commercial fod intended for infants and young children
• Development of quantitative and qualitative molecular biological methods to identify plant and animal species in foods (MolSpec-ID)- Details of Development of quantitative and qualitative molecular biological methods to identify plant and animal species in foods (MolSpec-ID)
• Practicability of the certification system concerning the prohibition of the use of genetically modified organisms (GMO) in organic farming- Details of Practicability of the certification system concerning the prohibition of the use of genetically modified organisms (GMO) in organic farming
• Extension of an animal study on bioavailability and metabolisation of 3-MCPD esters- Details of Extension of an animal study on bioavailability and metabolisation of 3-MCPD esters
• Fatty acids as endocrine disruptors: Influence of chain length, branched chains and multiple bonds of fatty acids on the activity of the estrogen receptors ER-Alpha and ER-Beta- Details of Fatty acids as endocrine disruptors: Influence of chain length, branched chains and multiple bonds of fatty acids on the activity of the estrogen receptors ER-Alpha and ER-Beta
• Molecular effects of flavonoid quercetin on human primary hepatocytes compared to those in mouse liver- Details of Molecular effects of flavonoid quercetin on human primary hepatocytes compared to those in mouse liver
• Effect of folate oversupplementation on the methylation status of tumour suppressor genes in immortalized human colon epithelial cells.- Details of Effect of folate oversupplementation on the methylation status of tumour suppressor genes in immortalized human colon epithelial cells.
• Uptake and toxicity of nanoparticles regarding coating and ion release in Caco-2-coculture- Details of Uptake and toxicity of nanoparticles regarding coating and ion release in Caco-2-coculture
• Interactions of silver-nanoparticles with cellular membrane proteins – influence of the stabilizers to form a protein corona and particle-toxicity- Details of Interactions of silver-nanoparticles with cellular membrane proteins – influence of the stabilizers to form a protein corona and particle-toxicity
• Effects of natural occuring fatty acids on the bioavailability and the metabolism of polycyclic aromatic hydrocarbons by taking the example of benzo[a]pyrene- Details of Effects of natural occuring fatty acids on the bioavailability and the metabolism of polycyclic aromatic hydrocarbons by taking the example of benzo[a]pyrene
• Proteomic investigations into silver nanoparticle-induced effects after 28-days subacute oral treatment in rats- Details of Proteomic investigations into silver nanoparticle-induced effects after 28-days subacute oral treatment in rats
• Proteomic investigations into 2-MCPD and 2-MCPD-distearate-induced effects after 28-days subacute oral treatment in rats- Details of Proteomic investigations into 2-MCPD and 2-MCPD-distearate-induced effects after 28-days subacute oral treatment in rats
• Species-dependent formation of okadaic acid metabolites in the liver and identification of involved xenobiotic-metabolizing enzymes- Details of Species-dependent formation of okadaic acid metabolites in the liver and identification of involved xenobiotic-metabolizing enzymes
• Use of the high resolution Exactive mass spectrometer for the residue analysis of pharmacologically active substances (Transfer of pharmacologically active substances into food of plant origin)- Details of Use of the high resolution Exactive mass spectrometer for the residue analysis of pharmacologically active substances (Transfer of pharmacologically active substances into food of plant origin)
• Determination of 2-and 3-MCPD-fatty acids esters in human milk- Details of Determination of 2-and 3-MCPD-fatty acids esters in human milk
• Determination of pyrrolizidine alkaloids in food and feed (Start-up funding of a research project BMELV)- Details of Determination of pyrrolizidine alkaloids in food and feed (Start-up funding of a research project BMELV)
• Development of a method of analysis for the determination of glyciol fatty acid estern in oil, fat and fat containing foodstuffs- Details of Development of a method of analysis for the determination of glyciol fatty acid estern in oil, fat and fat containing foodstuffs
• Food authentication by Food-Fingerprinting with NMR spectroscopy and other spectroscopic techniques- Details of Food authentication by Food-Fingerprinting with NMR spectroscopy and other spectroscopic techniques
• Feeding of contaminated feed with melamine to laying hens to determine the carry over rate of melamine in eggs.- Details of Feeding of contaminated feed with melamine to laying hens to determine the carry over rate of melamine in eggs.
• Mechanisms and minimisation of matrix effects in quantitative trace analytics with electrospray mass spectrometry- Details of Mechanisms and minimisation of matrix effects in quantitative trace analytics with electrospray mass spectrometry
• Determination of fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD) in foodstuffs- Details of Determination of fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD) in foodstuffs
• Investigations of the mechanism of matrix effects occurring during ionization in LC-MS/MS instruments. Development of proposals to enhance the accuracy of residue determinations.- Details of Investigations of the mechanism of matrix effects occurring during ionization in LC-MS/MS instruments. Development of proposals to enhance the accuracy of residue determinations.
• SafeGuard. Work package 3.3 Quality control, analytics: Procedures and forecasting models in risk-oriented feed and food analysis and monitoring- Details of SafeGuard. Work package 3.3 Quality control, analytics: Procedures and forecasting models in risk-oriented feed and food analysis and monitoring
• Transfer and transformation of DSP toxins in blue mussels (Mytilus edulis L.)- Details of Transfer and transformation of DSP toxins in blue mussels (Mytilus edulis L.)
• Development and validation of methods for the simultaneous determination of more than 500 pesticides in food and water using Q TRAP LC-MS/MS- Details of Development and validation of methods for the simultaneous determination of more than 500 pesticides in food and water using Q TRAP LC-MS/MS
• Investigations on the carry over of Maduramicin from feed to egg- Details of Investigations on the carry over of Maduramicin from feed to egg
• Feeding of contaminated feed with tansy ragwort (Senecio jacobae) to small ruminants to determine the carry over rate of pyrrolizidine alkaloids in milk from small ruminants and to evaluate and validate a test method for the detection of PA´s in naturally contaminated samples- Details of Feeding of contaminated feed with tansy ragwort (Senecio jacobae) to small ruminants to determine the carry over rate of pyrrolizidine alkaloids in milk from small ruminants and to evaluate and validate a test method for the detection of PA´s in naturally contaminated samples
• Investigations of the microbial status of caviar from the retail market and wholesale with special emphasis of the occurrence of aquatic mycobacteria.- Details of Investigations of the microbial status of caviar from the retail market and wholesale with special emphasis of the occurrence of aquatic mycobacteria.
• Quantification of residues of coccidiostats in feed and food of animal origin caused by carry over from contaminated feed.- Details of Quantification of residues of coccidiostats in feed and food of animal origin caused by carry over from contaminated feed.
• Determination of Flavophospholipol in feedingstuffs- Details of Determination of Flavophospholipol in feedingstuffs
• Reviewing the application of Hydrophilic Interaction Chromatography (HILIC) for the determination of highly polar and ionic pesticide active ingredients- Details of Reviewing the application of Hydrophilic Interaction Chromatography (HILIC) for the determination of highly polar and ionic pesticide active ingredients
• Development of analysis methods for the determination of ergot alkaloids and monitoring in selected food and feed- Details of Development of analysis methods for the determination of ergot alkaloids and monitoring in selected food and feed
• Bioavailability of tenderisers in dust and food after oral administration in the model organism pig- Details of Bioavailability of tenderisers in dust and food after oral administration in the model organism pig
• Studies on the influence of sampling on the levels of dioxins and PCBs in fish- Details of Studies on the influence of sampling on the levels of dioxins and PCBs in fish
• Analysis of antibiotic residues in matrices of plant origin- Details of Analysis of antibiotic residues in matrices of plant origin
• Investigation of the in vitro metabolism of pyrrolizidine alkaloids- Details of Investigation of the in vitro metabolism of pyrrolizidine alkaloids
• Production of Alternaria toxins for analytical purpose- Details of Production of Alternaria toxins for analytical purpose
• Replacement of fetal calf serum in the embryonic stem cell test (EST) – Standardization of culture conditions for proliferation and differentiation of embryonic stem cells of the mouse- Details of Replacement of fetal calf serum in the embryonic stem cell test (EST) – Standardization of culture conditions for proliferation and differentiation of embryonic stem cells of the mouse
• The isolated perfused bovine udder as an in vitro model for the evaluation of sensibilisation/sensitisation induced by chemicals- Details of The isolated perfused bovine udder as an in vitro model for the evaluation of sensibilisation/sensitisation induced by chemicals
• HPCT-1E3 hepatocytoma cultures for determination of cytotoxicity, toxicokinetic interactions and cholestatic effects, pre-validation study- Details of HPCT-1E3 hepatocytoma cultures for determination of cytotoxicity, toxicokinetic interactions and cholestatic effects, pre-validation study
• Evaluation of Alternative Methods to Animal Experiments in Life Sciences- Details of Evaluation of Alternative Methods to Animal Experiments in Life Sciences
• Normal human neural progenitorcells as a screening model for substances that are toxic for neural development.- Details of Normal human neural progenitorcells as a screening model for substances that are toxic for neural development.
• Development and Validation of an Inductive Database for the Prediction of Carcinogenic Effects of Chemicals- Details of Development and Validation of an Inductive Database for the Prediction of Carcinogenic Effects of Chemicals
• Characterisation and prevalidation of a new human cornea equivalent model for the evaluation of ocular toxicity- Details of Characterisation and prevalidation of a new human cornea equivalent model for the evaluation of ocular toxicity
• Optical probe technique for the assessment of multidrug resistance profiles in 3-dimensional in vitro tumor models- Details of Optical probe technique for the assessment of multidrug resistance profiles in 3-dimensional in vitro tumor models
• Prevalidation of human cornea model based on immortalized corneal cell lines as in vitro alternative to the Draize eye test.- Details of Prevalidation of human cornea model based on immortalized corneal cell lines as in vitro alternative to the Draize eye test.
• List of chemicals with missing IC 50-values and/or LD 50-values- Details of List of chemicals with missing IC 50-values and/or LD 50-values
• Computerised risk assessment of dermal absorption of active agents- Details of Computerised risk assessment of dermal absorption of active agents
• In vitro exposure of lung cells with aerosol at the air-liquid-layer as an alternative for inhalation experiments with animals- Details of In vitro exposure of lung cells with aerosol at the air-liquid-layer as an alternative for inhalation experiments with animals
• Development of bioreactors for in vitro testing of biological heart valves for reduction of animal experiments- Details of Development of bioreactors for in vitro testing of biological heart valves for reduction of animal experiments
• Embryonic stem cell-based novel alternative testing strategies (ESNATS)- Details of Embryonic stem cell-based novel alternative testing strategies (ESNATS)
• Replacement of transgenic animal models for determination of in vivo mutations by refinement of regulatory animal studies with the technique of the Random Mutations Capture Assay- Details of Replacement of transgenic animal models for determination of in vivo mutations by refinement of regulatory animal studies with the technique of the Random Mutations Capture Assay
• Development of a biotransformation system for the metabolic activation of validated in vitro systems to study embryotoxicity- Details of Development of a biotransformation system for the metabolic activation of validated in vitro systems to study embryotoxicity
• Studies on the anti-oxidative responses of lung cells as an endpoint for the assessment of aerosols after exposure at the air-liquid interface- Details of Studies on the anti-oxidative responses of lung cells as an endpoint for the assessment of aerosols after exposure at the air-liquid interface
• Development of Predictive In Vitro Test for Developmental Neurotoxicity testing- Details of Development of Predictive In Vitro Test for Developmental Neurotoxicity testing
• Best Search Practice on Animal Alternatives - A Guide for Untrained Database Users- Details of Best Search Practice on Animal Alternatives - A Guide for Untrained Database Users
• Development and evaluation of alternative methods to replace animal experiments (NIH-Test) for the potency measure of vaccines against rabies- Details of Development and evaluation of alternative methods to replace animal experiments (NIH-Test) for the potency measure of vaccines against rabies
• Preparation for external prevalidation: Optimization of the internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro by determination of the angiogenic standard of the cells to be used- Details of Preparation for external prevalidation: Optimization of the internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro by determination of the angiogenic standard of the cells to be used
• Establishment of normal human neural progenitor cells as an in vitro screening model for the evaluation of the neurotoxic potential of chemicals- Details of Establishment of normal human neural progenitor cells as an in vitro screening model for the evaluation of the neurotoxic potential of chemicals
• Improvement of the embryonic stem cell test (EST) using neural marker genes for testing the developmental neurotoxicity in vitro- Details of Improvement of the embryonic stem cell test (EST) using neural marker genes for testing the developmental neurotoxicity in vitro
• Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances- Details of Development of a single cell model of adult cardiomyocytes as a replacement method of animal experiments? Optical measurements of excitation-contraction coupling under the influence of test substances
• Estimating the risk of substances by spatial multi-biomarker profiling of 3D tissue cultures- Details of Estimating the risk of substances by spatial multi-biomarker profiling of 3D tissue cultures
• Development of a novel approach in hazard and risk assessment of reproductive toxicity by a combination and application of in vitro, tissue and sensor technologies - ReProTect- Details of Development of a novel approach in hazard and risk assessment of reproductive toxicity by a combination and application of in vitro, tissue and sensor technologies - ReProTect
• Refinement of the LCSA (loose-fit coculture-based sensitization assay)- Details of Refinement of the LCSA (loose-fit coculture-based sensitization assay)
• Equine precision cut lung slices as an in vitro model of obstructive airway diseases for the identification and characterization of drug targets- Details of Equine precision cut lung slices as an in vitro model of obstructive airway diseases for the identification and characterization of drug targets
• Gastric cell lines to substitute native cells of the gastric gland to study acid secretion in special consideration of preclinical studies- Details of Gastric cell lines to substitute native cells of the gastric gland to study acid secretion in special consideration of preclinical studies
• Joint project: Pluripotent stem cells in automated prediction of developmental osteotoxizität. Subproject 3: Development and establishment of a Osteoblsten differentiation assays- Details of Joint project: Pluripotent stem cells in automated prediction of developmental osteotoxizität. Subproject 3: Development and establishment of a Osteoblsten differentiation assays
• Joint Project: Development of an in vitro embryo toxicity tests with mouse embryonic stem cells: Subproject 1 - Analysis of embryotoxic effects in the light of new endpoints and metabolism using an expanded selection of materials- Details of Joint Project: Development of an in vitro embryo toxicity tests with mouse embryonic stem cells: Subproject 1 - Analysis of embryotoxic effects in the light of new endpoints and metabolism using an expanded selection of materials
• Improving the gain of transgenic mouse embryos for cryopreservation- Details of Improving the gain of transgenic mouse embryos for cryopreservation
• Development of an in vitro model (skin culture from slaughtered animals) to study the influence of compounds on wound healing.- Details of Development of an in vitro model (skin culture from slaughtered animals) to study the influence of compounds on wound healing.
• Development of methods for the isolation and analysis of Yessotoxin- Details of Development of methods for the isolation and analysis of Yessotoxin
• Biotechnological derived skin models for the cutaneous uptake of steroid hormone formulations- Details of Biotechnological derived skin models for the cutaneous uptake of steroid hormone formulations
• Further development of a 3D-model of substance distribution in the cochlea after round window application- Details of Further development of a 3D-model of substance distribution in the cochlea after round window application
• siRNA technology in mammalian cells as alternative of knock-out mice: Functional investigations of proteins of the Myc-Miz-1-TopBP1-network (translation).- Details of siRNA technology in mammalian cells as alternative of knock-out mice: Functional investigations of proteins of the Myc-Miz-1-TopBP1-network (translation).
• Use of transgenic animals in biomedical research in Germany - survey 2001 to 2003 and perspectives to change research to non-animal test methods- Details of Use of transgenic animals in biomedical research in Germany - survey 2001 to 2003 and perspectives to change research to non-animal test methods
• Construction and Prevalidation of V79 Pathway Cell Lines: Heterologous Co-Expression of human Cytochrom P450 1A2 and polymorphic forms of human N-Acetyltransferase in V79 Chinese Hamster Cells for in vitro-studies on toxicity and metabolism of chemicals and drugs.- Details of Construction and Prevalidation of V79 Pathway Cell Lines: Heterologous Co-Expression of human Cytochrom P450 1A2 and polymorphic forms of human N-Acetyltransferase in V79 Chinese Hamster Cells for in vitro-studies on toxicity and metabolism of chemicals and drugs.
• Improvement of an in vitro stem cell assay for developmental toxicity: Establishing molecular endpoints of tissue specific development- Details of Improvement of an in vitro stem cell assay for developmental toxicity: Establishing molecular endpoints of tissue specific development