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MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE)
Institution
Section overview
Description
The department investigates the physiological and biochemical effects of foods and food components, in order to identify health benefits and potential risks.
Special attention is on the metabolic syndrome (obesity, diabetes, dyslipidemia, hypertension), bone metabolism, immune system and the gastro-intestinal tract, as well as on the identification of functional food ingredients (probiotics, prebiotics, phytochemicals), taking in consideration individual genetic characteristics. Studies are done in humans, animal models and cell systems. This should provide a basis for recommendations of a health-maintaining and –promoting diet.
Activities
- Research
Parent institution
Max Rubner-Institut - Federal Research Institute of Nutrition and Food (MRI)
Coordinated projects
- Assessment of the impact of milk and dairy on human metabolism and on health
- Assessment of the nutritional quality of organic food by quantitating their antioxidative potential
- Basic molecular principals of the effects of food on the gastrointestinal tract and the immune system
- Bioactivity and mechanisms (antigenotoxic, antioxidative, modulation of signal transduction and barrier function) of food and food constituents
- Bioavailability and metabolism of anthocyanins as well as their interaction with topoisomerases and topoisomerase inhibitors in rats
- Biofunctionality of food and food ingredients on energy homoeostasis
- Biokinetic of the rare sugar D-Allulose in human blood and urine
- Biokinetic of the rare sugar D-Allulose in human blood and urine
- Biomarkers for food intake
- Cellular uptake, metabolism and transport of food constituents in cell culture models
- Chocolate carotenoids and Vitamin A
- Cohort Study on Plant-based Diets
- Comparision of different methodogical approaches in the personalized nutrition
- Determination of phytic acid and other inositol phosphates in foods.
- Developement of an enzyme-linked assay (ELISA) for determination of pyrrolizidine alkaloid (PA)-protein adducts as biomarkers for the detection of PA-exposure in livestock
- Developement of an enzyme-linked assay (ELISA) for determination of pyrrolizidine alkaloid (PA)-protein adducts as biomarkers for the detection of PA-exposure in livestock
- Development of characterization and fractionation/purification methods for organic nanoparticles, exemplified by extracellular vesicles from lactic bacteria.
- DO-HEALTH - Vitamin D3 - Omega 3 - Home Exercise - Healthy Ageing and Longevity Trial and Health Economic Impact Evaluation
- DO-HEALTH: VitaminD3-Omega3-Home Exercise - HeALTHy Ageing and Longevity Trial
- Effect of dietary lipids and other food constituents on lipid metabolism
- Effect of food processing on the bioaccessibility of nutrients. Investigations with the tiny-TIM system
- Effect of quercetin on biomarkers for cardiovascular risk in subjects with various apoE isoforms (intervention study)
- Effects of basic whey proteins and glycomacropeptide (GMP)on anabolic and catabolic processes of the bone
- Effects of polyphenols/flavonoids on the metabolic sensitivity of the cell: cellular mechanisms and relevance in vitro and in vivo
- Front-of-Pack Nutrition Labelling/Nutri-Score – nutritional evaluation and consulting for the Federal Ministry of Food and Agriculture
- Functional characterization of the human metabolome
- gern survey: Health and nutrition survey in Germany
- Health effects of increased legume consumption in humans
- Human phytochemical bioavailability and function
- Immunomodulatory effects of food ingredients
- Impact of diet and exercise intensity on metabolic effects
- Impact of food-borne microorganisms on the intestinal microbiota
- Impact of nutrition and physical activity on human metabolism and risk factors for life style associated diseases
- Impact of soluble dietary fiber on gut morphology
- Impact of specific food components on the gut microbiota
- Impact of thermal food processing on energy utilisation in humans
- Implementation and Standardization of Microbiota Analyses
- Improving the health quality of food by increasing and modifying the carotenoid content
- Influence of dietary pulses on gut barrier function
- Influence various whole grain fractions on obesity
- Literature Survey on the impact of milk and dairy on human metabolism and health
- Metabolic markers of diet and physical activity in humans
- Methylated amines in vivo after dairy consumption
- Microalgae
- miRNA – their role as modulators of metabolic effects
- Modulation of the in vivo bioavailability and bioactivity of apple flavonoids by application of submicro-/nano-formulation techniques
- National strategy for food reformulation: evaluation of international reformulation initiatives
- Nutrhi.net - the nutrition network located in the 'medial rhine region'
- Nutrition and intestinal microbiota
- Nutritional evaluation of alternative protein sources
- Nutritional evaluation of caloric and non-caloric sweeteners
- Pilot Studies "Nutritional Epidemiology” and “Epidemiology of chronic diseases”, implemented within NFDI4Health (National research data infrastructure on personal health data)
- PROMISE Study - PRedictors linking Obesity and gut MIcrobiomE
- Single nucleotide polymorhisms in nutritional physiology and prevention
- Stimulation of natural killer cell functions by L. casei Shirota in healthy individuals with a low killer cell activity
- The nutritional physiological and health significance/relevance of functional food.
- Transnational Knowledge Platform on Food, Diet, Intestinal Microbiomics and Human Health - subproject 1
Involved in research projects
- BRAFO - A specific support action to investigate the risk benefit analysis for foods
- Characterization of silver protein complexes relating to particle size and surface charge
- Collaborative project: Functionalization of insect-based flours by extrusion processing for the applications in bakery products - subproject 1
- Collaborative project: Plasma-based decontamination of dried plant-related products for an enhancement of food safety. Subproject: Analysis of plasma-treated plant products
- Collaborative project: Research on basic principles for the production of breakfast cereals with reduced energy density enriched in dietary fibre and polyphenols - subproject 1
- Develop a procedure for the isolation of phospholipids from whey cream and proof of the health potential of phospholipids
- Food and gut microbiota
- Food and Gut Microbiota
- Food Metabolome: Development of methods and characterisation of plant derived foods
- Functional characterization of the human metabolome – Nutritional behaviour
- Functional meat products
- German National Nutrition Survey III
- German Nutrient Database
- German-French nutrition network in the region 'Mittlerer Oberrhein' (InterReg IVA) (Nutrhi.net)
- Identification and characterization of functional traits of probiotics in relation to their physiological effects
- Impact of the particle size within the submicron/nanometer range on the bioavailability of phenolic compounds from berry pomace
- OODBALL-GER: Food Biomarker Alliance. Identification and validation of biomarkers of food intake and nutritional status
- Overview and evaluation of relevant sugar, fat and salt substitutes
- Product monitoring in the scope of the national reduction and innovation strategy for sugar, fats and salt in processed foods
- Quality analysis of critical control points within the whole food chain and their impact on food quality, safety and health (QACCP)
- Safety of L-Carnitin as a dietary supplement using a multi-platform metabolomics approach
Contact
MRI - Department of Physiology and Biochemistry of Nutrition
(MRI-PBE)
Haid-und-Neu-Str. 9
76131 Karlsruhe
Baden-Württemberg
Germany
Phone: +49 721 6625 0
Fax: +49 721 6625 111
Email: bernhard.watzl(@)mri.bund.de
