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BfR - Department 9: Experimental Toxicology and ZEBET (BfR - TOX)
Institution
Section overview
Description
In the Department “Experimental Toxicology and ZEBET” molecular toxicologists and nanotoxicologists will in future work closely together with ZEBET which has been established since more than two decades. ZEBET is the Centre for the Documentation and Evaluation of Alternatives to Animal Experiments at BfR.
The objective is a close networking of toxicological expertise for the purpose of establishing and validating in vitro- and in silico methods which are to replace the regulatory animal experiments in chemical safety assessment. In this way the expert knowledge of ZEBET gained over the last years is complemented and strengthened by other areas which will contribute towards the clarification of the mechanisms of toxicity induced by chemicals and / or nanoparticles.
Through the joint appointment of a W3 university chair of BfR and Charité it will moreover, be possible to increasingly integrate the 3R concept at the university level and in fundamental research. Furthermore, research on the third 'R', ie refinement, is to be established and advanced in this Department. For that reason the laboratory animal husbandry of BfR (Unit 'Reference Material and Certification') is integrated into Department 9.
Activities
- Research
Parent institution
Coordinated projects
- Analysis of the effects of developmental toxins from consumer products on microRNA (miRNA) expression during differentiation of embryonic stem cells. Identification of novel molecular endpoints and studies on the role of miRNAs in developmental toxicity
- Analysis of the funtional interaction of the circadian rythm with the endocrine system for the establishment of sensitive in vitro test systems.
- Berlin-Brandenburg Research Platform BB3R with Integrated Graduate Education 'Innovations in the 3R Research - Genetic Engineering, Tissue Engineering and Bioinformatics' - Subproject 4: 'Individualized pain suppression in mice' (Work program Dept. 9) and 'Development of a nanotoxicology test platform for testing the inhalation toxicity of nanoparticles in vitro' (work program Dept. 7)
- Development and validation of molecular toxicological test methods for chemical safety: design and establishment of new in vitro and non-vertebrate testassays
- Evaluation of the genotoxic potenital of selected synthetically synthesized nanomaterials through application of alternative methods
- Identification of Nrf2-target genes in human THP-1 monocytes 2009: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis 2010: Identification of Nrf2 target genes in human THP-1 monocytes upon treatment with contact allergens by means of proteomic analysis
- Mechanistic investigation of the influence of potential ED in the model organism C. elegans
- SMAFIRA – Smart Feature-based interactive ranking
Involved in research projects
Contact
BfR - Department 9: Experimental Toxicology and ZEBET
(BfR - TOX)
Max Dohrn-Str. 8-10
10589 Berlin
Berlin
Germany
Phone: +49-(0)30-18412-2275
Fax: +49-(0)30-18412-2958
Email: 9(@)bfr.bund.de
