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Leibniz Institute for Molecular Pharmacology (FMP)
Institution
Section overview
Description
The FMP makes contributions of fundamental significance in the field of molecular pharmacology. FMP research focusses on the structures, functions and interactions of proteins and on the development of new concepts for interfering pharmacologically with their functions. This places the research activity of the institute at the forefront of drug development. An interdisciplinary approach is crucial to this type of work, and a particular strength of the FMP is the close interaction in the fields of chemistry and biology.
Activities
- Research
Networks
Involved in research projects
- Application of 2-DE-based proteomics for biomarker detection in human plasma
- Application of 2-DE-based proteomics in vitro
- Detection and analysis of hepatotoxic modes of action for the prediction of carcinogenic effects of chemicals in the subacute toxicity test (repeated dose 28-day oral toxicity study/ OECD TG 407)
- Development and use of catalysts for oxidation of low-molecular carbohydrates 1: Screening of catalysts and testing
- Development and validation of molecular toxicological test methods for chemical safety: design and establishment of new in vitro and non-vertebrate testassays
- Identification and prevalidation of hepatocellular biomarkers for detection and prediction of carci-nogenic effects of chemicals (part 1)
- Identification of protein-biomarkers in human- and mouse-plasma after exposure to Dioxin.
- Proteomanalyses of different liver tumors of mice with activating mutations in the oncogenes ß-Catenin, Ha-Ras and B-Raf
- Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances
Contact
Leibniz Institute for Molecular Pharmacology
(FMP)
Robert-Rössle-Str. 10
13125 Berlin
Berlin
Germany
Phone: +49-(0)30/94793 - 102
Fax: +49-(0)30/94793 - 109
Email: maul(@)fmp-berlin.de
