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Imprint
Biochemical-bioinformatic analysis of reactive hepatotoxic substances in a hepatic co-culture system
Project
Project code: BfR-CPS-08-1329-556
Contract period: 01.11.2016
- 30.09.2017
Purpose of research: Applied research
The overarching goal in health sciences is a better understanding of molecular toxicity mechanisms, also in liver. Therefore, the project aims to study the metabolomic and toxicoproteomic effects two chemicals, 5-Chlor-2-methyl-4-isothiazolin-3-on (CMI) and caffein using a co-culture modell of hepatocytes and monocytes. The determination of the degradation products will allows to conclude on the effective concentrations of the main substances and their degradation products. The mode of actions as well as potential diagnostic biomarkers will be derived, based on expression profiles of 180 endogeneous metabolites and 2000 proteins. The results should allow an improved risk assessment. The integration of metabolome and proteom data should open new views on involved metabolic pathways and signalling cascades.
Section overview
Subjects
- Food Chemistry
- Toxicology
