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Antibiotic Resistance Dynamics: the influence of geographic origin and management systems on resistance gene flows within humans, animals and the environment (ARDIG)

Project


Project code: BfR-BIOS-08-1342
Contract period: 01.01.2018 - 31.12.2020
Purpose of research: Applied research

WP1: To compare AMR prevalence in six different European regions collected through national surveillance, including EU and other surveillance programmes, from humans, animals, food and the environment and to correlate resistance trends with antibiotic sales or usage (available through research project or industry data and by collecting primary data) and management practices. WP2: To perform longitudinal studies to determine prevalence of ESBL/AmpC/carbapenemase producing or mcr-1 and -2 /PMQR-carrying Enterobacteriaceae in pig, poultry, cattle farms or hospitals and their environments, comparing national AMR prevalence data with herd/hospital level prevalence. WP3: To characterise resistance mechanisms e.g ESBL/AmpC/carbapenemase/mcr-1 and -2/PMQR production and mobile elements at the molecular level in Enterobacteriacea isolates from different epidemiological units/ecological niches across geographic regions. Importantly, their transmission dynamics and stability in different bacterial hosts and environments; the fitness cost associated with AMR will be measured in vitro and in vivo.

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Subjects

Framework programme

BMEL - research cluster

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