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In-vitro bioavailability and toxicity of phloridzin loaded nano- and submicron chitosan particles
Project
Project code: MRI-LBV-08-1030 Chitosanprojekt
Contract period: 01.12.2016
- 31.12.2020
Purpose of research: Experimental development
Keywords: Nanotechnology
The delivery of bioactive compounds through carrier systems and thereby the enhancement of the compounds’ bioavailability is of great interest. Recent studies indicate that especially a particle size within the nanometer range can impact the bioavailability of nutrients from food matrices. Phloridzin is a secondary plant metabolite with anti-diabetic activity but low bioavailability. We hypothesize that the encapsulation of phloridzin in nano-scaled chitosan particles increases the in-vitro bioavailability more than its encapsulation in submicron-scaled chitosan particles. To prove this hypothesis, we encapsulate phloridzin in formulations of different particle size. The in-vitro bioavailability will be tested in cell culture tests. Furthermore, in-vitro toxicity tests will be carried out.
Section overview
Subjects
- Physiology of Nutrition
- Renewable Resources
Framework programme
Funding programme
Excutive institution
MRI - Department of Food and Bio Process Engineering (MRI-LBV)
