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In vitro tests for photogenotoxicity assessment as alternatives to photocarcinogenicity tests in ro-dents (Project part 1).
Project
Project code: BfR-QUER-02-1334-161
Contract period: 01.08.2002
- 31.07.2004
Purpose of research: Applied research
Materials, which are photo-activated under the influence of light (in particular the UV portion of the sunlight) may form reactive intermediates that when dermal exposition is given, can result in DNA damages and thus increase the risk of light induced skin tumors. The evaluation of the photo-carcinogenic potential is therefore essential part of the safety examination of ingredients of certain pharmaceuticals and cosmetics. At present the experimental examination of photocarcinogenicity is usually accomplished in a one year study on the substance mediated increase of light induced tumors in hairless mice connected with substantial suffering for the animals. It is therefore goal of the project to prevalidate in a ring trial two in vitro photogenotoxicity tests, the photo micronucleustest (P-MNT) and the photo cometassay (P-COM) die as possible alternatives to predict the photocarcinogenic potential of substances.
Section overview
Subjects
- Biotechnology
- Toxicology
