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Functional characterization of the human metabolome

Project

Food and consumer protection

This project contributes to the research aim 'Food and consumer protection'. Which funding institutions are active for this aim? What are the sub-aims? Take a look:
Food and consumer protection


Project code: MRI-PBE-08-102
Contract period: 01.01.2001 - 31.12.2021
Purpose of research: Basic research

Metabolomics is the qualitative and/or quantitative analysis of the metabolome, i. e. all low molecular weight compounds, in a biological system. The metabolome is composed of endogenous (produced by the body) as well as exogenous (from food or other environmental sources) metabolites, and is influenced by a number of factors, including gender, age, nutrition, physical activity etc. In nutrition research, the aim is to identify biomarkers that guide measures to prevent the onset of disease and relate those markers to dietary patterns. In the present project, the Max Rubner-Institut will use metabolomics to thoroughly characterize healthy human volunteers. Various chromatography-coupled mass spectrometric techniques as well as nuclear magnetic resonance (NMR) will be used to analyze plasma, serum, and urine samples of these volunteers. Using the appropriate bioinformatic techniques, metabolites or metabolite patterns that are characteristic for the studied gender or age groups as well as the variability of selected metabolite groups will be determined. Parallel to that, the nutritional behavior of the volunteers will be assessed in order to identify metabolites that are representative of certain dietary patterns. The ultimate goal will be to integrate the nutritional behavior with the metabolic profile of an individual to be able to take appropriate measures to maintain health and prevent the development of diet-associated diseases.

Merz B, Frommherz L, Rist MJ, Kulling SE, Bub A, Watzl B. Dietary Pattern and Plasma BCAA-Variations in Healthy Men and Women-Results from the KarMeN Study. Nutrients. 2018;10(5). Rist MJ, Roth A, Frommherz L, Weinert CH, Krüger R, Merz B, et al. Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study. PLoS One. 2017;12(8):e0183228. Krüger R, Merz B, Rist MJ, Ferrario PG, Bub A, Kulling SE, et al. Associations of current diet with plasma and urine TMAO in the KarMeN study: direct and indirect contributions. Mol Nutr Food Res. 2017;61(11). Bub A, Kriebel A, Dörr C, Bandt S, Rist M, Roth A, Hummel E, Kulling S, Hoffmann I, Watzl B. The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women. JMIR Res Protoc 2016;5(3):e146 Frommherz L, Bub A, Hummel E, Rist MJ, Roth A, Watzl B, et al. Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study. PLoS ONE 2016; 11(4): e0153959. Krüger R, Merz B, Rist M, Bub A, Kulling S, Watzl B. Associations of plasma and urine TMAO with actual diet of healthy individuals in KarMeN. Max Rubner Conference 2016: Food Metabolomics, (2016), S. 48 Merz B, Rist M. The KarMeN-Study: Biomarkers of age, sex, and diet. Max Rubner Conference 2016: Food Metabolomics, (2016), S. 25 Bub A, Kriebel A, Dörr C, Bandt S, Rist M, Roth A, Hummel E, Kulling S, Hoffmann I, Watzl B. The Karlsruhe Metabolomics and Nutrition (KarMeN) Study: Protocol and Methods of a Cross-Sectional Study to Characterize the Metabolome of Healthy Men and Women. Max Rubner Conference 2016: Food Metabolomics, (2016), S. 47 Rist M, Roth A, Frommherz L, Weinert C, Egert B, Bub A, Krüger R, Hoffmann I, Kulling S, Watzl B. Metabolite patterns characterising age and sex in participants of the “KarMeN”-study. 12th European Nutrition Conference (FENS): Abstracts (10.2015), S. 270 Mack C, Weinert C, Egert B, Bub A, Watzl B, Kulling S. Semi-targeted metabolomics for the analysis of urinary sugar species: Application an the KarMeN cohort. MetaboMeeting 2015 Krüger R, Roth A, Bandt S, Bub, A. Serum 25-Hydroxyvitamin D Status of Healthy Adults: Results from the Karlsruhe Metabolomics and Nutrition Study (KarMeN). ISMC 2014 20th International Mass Spectrometry Conference, (2014), S. 363-364 Krüger R, Roth A, Bandt S, Bub A, Watzl B. 25-Hydroxyvitamin D Serumkonzentrationen gesunder Erwachsener bei KarMeN, einer Metabolomics-Studie mit Focus Ernährung. DGMS 2014: 47. Jahrestagung der Deutschen Gesellschaft für Massenspektrometrie Rist M, Bub A, Bandt S, Kriebel A, Roth A, Krüger R, Weinert C, Egert B, Frommherz L, Hummel E, Wittig F, Hoffmann K, Hoffmann I, Kulling S, Rechkemmer G, Watzl B. The KarMeN-cohort: a cross-sectional study applying a multi-method platform to assess the human metabolome and its major determinants. Second International Congress of Translational Research in Human Nutrition, (2013), S. P020 Weinert C, Rist M, Frommherz L, Egert B, Roth A, Bub A, Luy B, Watzl B, Rechkemmer G, Kulling S. The Karlsruhe Metabolomics and Nutrition (KarMeN) multi-platform approach. Second International Congress of Translational Research in Human Nutrition, (2013), S. P024 Bandt S, Kriebel A, Dörr C, Rist M, Roth A, Härtel S, Neumann R, Kulling S, Rechkemmer G, Watzl B, Bub A. The impact of physical activity and fitness on the human metabolome in the KarMeN cohort. Second International Congress of Translational Research in Human Nutrition, (2013), S. P030 Mack CI, Weinert CH, Egert B, Ferrario PG, Bub A, Hoffmann I, et al. The complex human urinary sugar profile: determinants revealed in the cross-sectional KarMeN study. Am J Clin Nutr. 2018;108(3):502-16. Epub 2018/12/12. Armbruster M, Rist M, Seifert S, Frommherz L, Weinert C, Mack C, et al. Metabolite profiles evaluated, according to sex, do not predict resting energy expenditure and lean body mass in healthy non-obese subjects. Eur J Nutr. 2019;58(6):2207-17. Ferrario PG. A new workflow combining R packages for statistical analysis of metabolites. bioRxiv. 2019:848812. Mack CI, Egert B, Liberto E, Weinert CH, Bub A, Hoffmann I, et al. Robust Markers of Coffee Consumption Identified Among the Volatile Organic Compounds in Human Urine. Mol Nutr Food Res. 2019;63(10):e1801060. Vazquez-Manjarrez N, Weinert CH, Ulaszewska MM, Mack CI, Micheau P, Petera M, et al. Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies. J Nutr. 2019;149(10):1701-13. Roggensack T, Merz B, Dick N, Bub A, Kruger R. Targeted ultra-performance liquid chromatography/tandem mass spectrometric quantification of methylated amines and selected amino acids in biofluids. Rapid Commun Mass Spectrom. 2020;34(7):e8646. Soukup ST, Merz B, Bub A, Hoffmann I, Watzl B, Steinberg P, Kulling SE. Glyphosate and AMPA levels in human urine samples and their correlation with food consumption: Results of the cross-sectional KarMeN study in Germany. Archives of Toxicology, accepted 09032020

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BMEL Frameworkprogramme 2008

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