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FOR 566: Veterinary Medicines in Soils - Basic Research for Risk Analysis
Collaborative Project
Coordinating institution:
Institute of Crop Science and Resource Conservation
In the first phase of this research unit, we have been identifying the major mechanisms that control the fate and effects of manure-applied sulfadiazine (SDZ) and difloxacin (DIF) in soil. For this purpose, animals were treated with radiolabelled compounds and the contaminated manure was homogeneously amended to two soil types. The antibiotics changed microbial community structure, functions and resistance gene abundance in soils. However, the effects observed so far lagged behind the maximum bioavailable concentrations. The objective of the second project phase of this research unit is now to test the hypotheses that (i) it is the 4-hydroxy metabolite of sulfadiazine that controls its long-term fate, that (ii) it is the history of manuring and the functional redundancy of microorganisms that controls the effects, that (iii) the disappearance dynamics of antibiotics determines the duration but (iv) additional organic substances enhance the intensity of the observed effects for both antibiotics in soil. A particular focus is laid on the rhizosphere, since this region comprises a hot-spot of microbial abundance and activity in soil. To isolate rhizosphere effects from varying environmental conditions, all studies are first performed in central mesocosm experiments. It is accompanied by a central field experiment where also effects of repeated manure application and functional redundancy to legume-assisted bacteria are investigated. Seven subprojects in the 2nd research phase continue to cover the sections A) Microexposure and Dynamics and B) Microbial toxicity, resistance development and community changes in rhizosphere and non-rhizosphere soil. The two project parts are, beside experimental collaborations, closely linked through C), the Integrated Modelling project, which has been involved since the 1st phase and provides the theoretical basis for these experiments.
Collaborative Projects
Project A1: Fate, metabolism and plant uptake of selected veterinary medicines in the rhizophere
Leading institution:
Institute of Environmental Research
Research projects
Project A2: Degradation and Residue Dynamics of Veterinary Medicines in Soil-Plant Systems
Leading institution:
Institute for Environmental Research
Research projects
Project A3: Sequestration of veterinary medicines in soil
Leading institution:
Institute of Crop Science and Resource Conservation
Project A4: Transport of veterinary medicines from soils to groundwater
Leading institution:
Research Center Juelich
Research projects
Project B1: Veterinary Medicinal Effects on the Prokaryotic Structural Diversity in Soil Microcompartments - VMMic
Leading institution:
Soil Science - Department of Geography / Geosciences
Research projects
Project B2: Effects of Veterinary Medicines on the functional diversity of the microbial biomass in soils
Leading institution:
Chair of Soil Science
Research projects
Project B3: Effects of veterinary medicined in manur on the abundance and transfer of bacterial antibiotic resistance genes in soil: importance of the rhizosphere and of repeated manure applications
Leading institution:
Institute for Epidemiology and Pathogen Diagnostics
Research projects
Project C: Modelling of rhizophere influences on interactions between chemical dynamics and effects of veterinary medicines in soil
Leading institution:
Institute of Environmental Systems Research
