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SFB 670: Cell-autonomous Immunity
Collaborative Project
Coordinating institution:
Institute for Medical Microbiology, Immunology and Hygiene
The response of an organism to pathogens proceeds in several steps, beginning with the natural barriers, e.g. the membrane of a plant cell or the skin of the mammalia, followed by the elements of the innate immunity, which enable an early defense reaction. The initial processing of the pathogen non-self antigens in somatic cells as well as the spatiotemporally concerted defense reaction including various elements of the innate immunity normally set the course for a coordinated and well-balanced adaptive immune reponse.
The SFB focusses on cell-autonomous detection and effector efforts, which enable macrophages, but also other non-professional phagocytes, to eliminate particularly intracellular microbial pathogens. Like higher vertebrates plants are able to defend themselves against microbial pathogens. As plants do not have a circulating immune system with antibodies and immune cells, every single cell of a plant must be able to detect and effectively eliminate microbial pathogens.
The distinct complexity of the research area poses a great challenge for the integrative understanding of the molecular interaction of animal and plant host cell components on the one hand with structures of intracellular pathogens on the other hand. The research groups in Cologne and Bonn open a special chance to gain new insights into the function of cell-autonomous defense and its consequences for the immune defense against infectious agents in a complementary and interdisciplinary research network.
Collaborative Projects
Subprojects
Research projects
- SFB 670 TP1: The professional phagocyte Dictyostelium as a host model for pathogens
- SFB 670 TP2: Molecular mechanisms of host cell entry by phytopathogenic powdery mildew fungi via suppression of cell-autonomous plant defence
- Molecular analysis of the interaction between pathogenic Rhodococcus equi and their host macrophages
- SFB 670 TP4: Role of sphingomyelinase for the membrane-bound antibacterial effector mechanisms
- SFB 670 TP5: Characterization and modulation of the Osteoblasts-specific Staphylococcus aureus phagosome
- SFB 670 TP6: Role of p47 (IRG) GTPases in cell-autonomous resistance to protozoal pathogens
- SFB 670 TP7: Function of heterotetrameric adaptor complexes in phagosome maturation
- SFB 670 TP8: Inhibition of AAV infection by intracellular defence mechanisms
- SFB 670 TP9: Cell autonomous defense in the control of hepatitis B virus infection
- SFB 670 TP10: Cell autonomous control of human papillomavirus infection
- SFB 670 TP11: Antiviral defence mechanisms in liver sinusoidal endothelial cells
- SFB 670 TP12: Molecular mechanisms of dendritic cell signal transduction subsequent to cellular infection by Vaccinia Virus or L. monocytogenes
- SFB 670 TP13: Induced Receptor Endocytosis in the Cell-Autonomous Plant Basal Immune Response
- SFB 670 TP15: Cell-autonomous role of TLR-induced signalling pathways in antibacterial immunity
- SFB 670 TP17: Role of insulin signal transduction in the regulation of innate immune response
- SFB 670 TP18: Intracellular perception of fungal effectors and initiation of signalling by allelic NB-LRR receptors
- SFB 670 TP19: Toll-related Intracellular Receptors in Plant Innate Immunity
- SFB 670 TP20: Distinction of self versus viral RNA by RIG-I and implication for viral infection
- SFB 670 TP N01: Analysis of Nod like receptor (NLR) mediated innate immunity in mammalian cells
