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Contribution of gamma/delta T cells to long-term immunity against Salmonella infection in chickens
Project
Project code: FLI-IMP-08-Je-0332
Contract period: 01.10.2025
- 30.09.2028
Purpose of research: Applied research
Keywords: Salmonella,T-cells
In the second ImmunoChick funding period, we want to continue our work and investigate whether γδ T cells can contribute to the development of immunological memory and fulfill specific functions to protect chickens long-term against Salmonella infections. Therefore, we will use Salmonella vaccinated and infected γδ T cell knockout and wild type chickens to analyse the potential immunological memory functions of γδ T and αβ T cells. To this end, we will measure the recall functions such as proliferation, migration and cytotoxicity of γδ and αβ T cells in vitro. In vivo, we will investigate the development of immunological γδ and αβ T memory cells. In addition, we will focus our research on the role of γδ T cell subsets in maintaining the integrity of the intestinal barrier in chickens. These experiments will reveal the location and distribution of γδ and αβ T cell subsets and different barrier-specific proteins in specific areas of the intestine of Salmonella vaccinated, infected and re-infected γδ T cell knockout and wild-type chickens. The proposed study is only possible through collaboration with ImmunoChick members and will provide important insights into both Salmonella infection and the immune system of chickens.
Section overview
