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Imprint
Using phosphoprotein profiling for the characterisation of effects of teratogenic substances on essential signal transduction pathways during the differentiation of mouse embryonic stem cells
Project
Project code: BfR-ZEBET-08-1328-448
Contract period: 01.12.2010
- 31.05.2011
Purpose of research: Applied research
The aim of this project is the identification of predictive signal transduction pathways for the identification of teratogenic compounds and to elucidate the molecular mechanisms underlying teratogenicity.
A number of known and important signal transduction pathways were analyzed in the course of differentiation of embryonic stem cells into cardiomyocytes and effects of retinoic acid and valproic acid on these pathways characterised. These data were compared with results obtained from biochemical studies (Western blot). To this end, not clear predictive pathways could be identified but evidence for potential interesting candidates was obtained.
Section overview
Subjects
- Toxicology
Framework programme
Funding programme
Excutive institution
BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET)
