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One health intervention preventing of zoonotic spreading of antibiotic resistant germs - Methicillin-resistente Staphylococcus aureus (MRSA) and further multiresistant pathogens in milk food chain (1Health-PREVENT)
Project
Project code: BfR-BIOS-08-1334-232
Contract period: 01.09.2017
- 31.08.2020
Purpose of research: Inventory & Assessment
MRSA as a mastitis-causing pathogen in dairy cows is a veterinary health issue and the possible spread of zoonotic MDRO from dairy cows via direct and/or indirect (raw milk) contact is also of relevance for human health. Thus, the major aim of the project, which perfectly addresses the One Health approach of the consortium, is the overall reduction of MDRO in dairy farming by tackling mastitis cases in dairy cows and limiting further spread of zoonotic MDRO such as MRSA to humans. Overall, the project aims to address the following main research questions:
1. What are likely sources of zoonotic MRSA and other MDRO in dairy farming systems?
2. What are the factors driving the dissemination of zoonotic MRSA mastitis in dairy cattle?
3. Does dry cow therapy with beta-lactams contribute to the selection for AMR bacteria in the mammary gland, possibly resulting in an increase of zoonotic MRSA and other MDRO?
4. Are zoonotic MRSA and other MDRO occurring in the dairy cow food chain of human health relevance, in particular for livestock professionals in close contact with dairy cows?
5. Does consumption of raw milk or the consumption of raw milk products contribute to the dissemination of zoonotic MRSA and other MDRO and resistance determinants to humans?
By answering these main research questions we hypothesise that appropriate interventions can be established to reduce the total burden of zoonotic MRSA mastitis in dairy cattle, subsequently preventing further spread and transmission of zoonotic MDRO from animals to humans. The addressed strategies will be of direct interest to the industry and will not necessarily require any direct action by veterinary authorities.
Section overview
Subjects
- Toxicology
