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Reprogramming of somatic cells and redifferentiation of embryonic cells
Project
Project code: FLI-ING-08-26
Contract period: 01.01.2001
- 01.06.2015
Purpose of research: Basic research
The goal of this project is the unravelling of molecular mechanisms critically involved in reprogramming following somatic nuclear transfer or the differentiation of pluri/totipotent embryonic cells. Bovine embryos derived from nuclear transfer are analysed and transcriptional and protein expression patterns are compared with these of its in-vivo and in-vitro derived counterparts.
Results are published in refereed journals, f.ex.
Kirchhof et al. (2000), Biology of Reproduction 63, 1708-1715;
Wrenzycki et al. (2001), Biology of Reproduction 65, 232-331;
Schätzlein et al. (2004), Proc. National Academy of Sciences (USA) 101, 8034-8038;
Nowak-Imialek et al. (2008) Molecular Reproduction Development 75, 731-745;
Schwarzer et al. (2006) Cloning and Stem Cells 8, 151-159.
Section overview
Subjects
- Animal breeding