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Scientific determination and assessment of consumer exposure to aniline derivative metabolites originating from plant protection products
Project
Project code: BfR-SiP-08-1322-
Contract period: 01.11.2017
- 31.12.2018
Purpose of research: Inventory & Assessment
The project builds upon the former project SFP 1322-677 (Assessment of pesticide metabolites with the use of MetaPath, (Q)SAR and toxicological data from the eASB database at BfR). A couple of active substances authorized for their use in plant protection products contain the aniline moiety and can form aniline and aniline derivative metabolites in plant and animal metabolism and under conditions of food processing. Since aniline and some of its derivatives are genotoxic carcinogens, they require specific consideration in consumer risk assessment. On EU level a list of potentially aniline-forming compounds was recently discussed, i.e. during the September meeting of the SCoPAFF (Standing Committee on Plants, Animals, Food and Feed, Section Phytopharmaceuticals - Pesticides Residues). This provisional list is, however, not the result of a systematic review. An overall dietary exposure assessment for aniline and aniline-derivative metabolites stemming from various active substances has not been conducted yet. Within the framework of this project, pesticides should be identified which might be able to form aniline (derivatives). For those pesticides all relevant metabolism studies (rat, livestock, plant) and studies on the nature of residues during processing should be assessed and the data entered into the MetaPath database. The software should then be used to identify common metabolic pathways. Aim of this project is to quantify the consumer exposure towards aniline and aniline-derivative metabolites stemming from active substances in plant protection products and to assess the results with respect to possible human health risks.
Section overview
Subjects
- Crop Protection
- Toxicology
- Computer science
