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Modelling of dermal exposure and absorption based on experimental data from Franz cell ex-periments on the migration of substances from plastics and elastomers with uptake into the skin

Project


Project code: BfR-CPS-08-1329-572
Contract period: 01.01.2018 - 31.12.2019
Purpose of research: Applied research

Many consumer goods are made out of plastics or elastomers, from which migratable substances such as additives (e. g., plasticizers, vulcanization accelerators) and contaminants (e. g., polycyclic aromatic hydrocarbons, PAHs) can be released. These substances could lead to a dermal exposure of consumers. Many existing experimental and modelling approaches consider the migration and dermal absorption as separate processes which, in case of extremely lipophilic substances, could result in an underestimation of consumer exposure. This has been demonstrated by Franz cell experiments with human skin in direct contact with plastics contaminated with PAHs. The aim of this project is to model the dermal exposure and absorption based on data from Franz cell experiments on the migration of substances from plastics and elastomers with uptake into the skin. Modelling approaches should be used which (i) mechanistically describe the relevant transport processes of diffusion and partitioning of substances at phase boundaries and which (ii) reflect the substructure of the skin in a realistic manner. By further developing established modelling approaches, the data obtained from Franz cell experiments with excised human skin for different migratable substances should be simulated in a time-resolved and spatially resolved manner. The results of this project should be fed into ongoing work of physiologically based pharmacokinetic (PBPK) modelling at the BfR.

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Subjects

Framework programme

BMEL - research cluster

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