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PENAGE (PENAGE)

Project


Project code: 031B0539
Contract period: 01.07.2018 - 30.06.2020
Budget: 387,943 Euro
Purpose of research: Experimental development

In recent years new molecular techniques were developed to edit genome loci in eukaryotes, whereas published results focus on ODM-, meganuclease-, TALEN- or RNA-guided nuclease (Cas)-based methods. So far, these methods have weaknesses concerning sequence recognition and/or binding affinity resulting in off-target mutations. In addition, most of them have been used efficiently only in transgenic approaches due to limitations in the transfer of the active effector complex into plant cells. Hence, the proposed project »PENAGE« tends to develop an innovative and future oriented technology for precise genome editing using novel effector molecules

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