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Imprint
Characterisation and comparison of Salmonella enterica subsp. diarizonae strains isolated from animal (mainly sheep), food and human sources.
Project
Project code: BfR-BIOS-08-1322-716
Contract period: 01.01.2019
- 31.12.2019
Purpose of research: Experimental development
The majority of disease inducing Salmonella in farm animals belongs to Salmonella enterica subsp. I (enterica). However, there are other Salmonella subsp. frequently found in animals. One example is Salmonella enterica subsp. diarizonae serovar IIIb 61:k:1,5,(7) , which is known to be highly adapted to sheep, but can be also found in other mammals, birds, reptiles and humans. Extensive studies have shown, that Salmonella 61:k:1,5,(7) could be detected in sheep herds from Sweden, Norway, UK, Spain, Italy, Switzerland and the USA. Colonization does not necessarily induce diseases. However, the strain can causes diarrhea, abortions and cases of chronic proliferative rhinitis. The serovar is rarely associated with disease in humans, but cases of severe infections in high risk groups (infants, immunocompromised adults and elderly) have been described. Aim of the study is to find out, whether human infections caused by Salmonella enterica subsp. diarizonae Serovar 61:k:1,5,(7) can be linked to the matrix sheep or whether another matrix needs to be considered as source of infection. Therefore sequencing of selected isolates as well as bioinformatics analysis of sequencing data is planned. As part of the strain collection at the NRL Salmonella, the BfR already has available isolates from sheep, other mammals (e.g. poultry, horse, and goat), food (cheese, minced meat and sausages), birds and reptiles collected between 2005 and 2018. Furthermore the Robert Koch-Institute is going to provide human isolates collected in the years 2001 to 2018. Another aim of the project is to investigate mechanisms of host adaption in Salmonella 61:k:1,5,(7) based on genome data. Therefore, distribution of virulence genes and virulence plasmids is of major interest. The project is intended to run for two years.
Section overview
Subjects
- Biotechnology
- Food microbiology
- Toxicology
