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Imprint
Development of bioreactors for in vitro testing of biological heart valves for reduction of animal experiments
Project
Project code: BfR-ZEBET-08-1328-183
Contract period: 01.11.2004
- 31.12.2006
Purpose of research: Applied research
For long term function prosthetic heart valves are tested in pulse duplicators. They enable opening and closing of the valves up to 3000 times a minute. This allows a reduction of the testing time from 5 years in vivo to 48 days in vitro. Biologic heart valves are much more delicate and will not sustain such testing. Due to this limitation and the current industrial testing norm (ISO 5840) biological heart valves undergo routinely testing in a large animal model (sheep or calf). The principle and co-principle investigators have gained substantial expertise in tissue engineering and haemodynamic testing of heart valves. This includes the development of two bioreactor systems to tissue engineer heart valves. These systems enable the simulation of physiologic blood pressure and flow conditions. Aim of this proposed project is the continuation of the development of these bioreactors towards a physiologic circulation to reduce currently required animal experiments.
Section overview
Subjects
- Food Chemistry
Framework programme
Funding programme
Excutive institution
BfR - Centre for Documentation and Evaluation of Alternatives to Animal Experiments (BfR - ZEBET)
