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Imprint
Expression of xenobioticametabolising Cytochrome P450 enzymes in human CD 34+ bone marrow stem cells
Project
Project code: BfR-CHS-02-1322-191
Contract period: 01.05.2004
- 31.12.2006
Purpose of research: Basic research
Bone marrow represents an important target for the toxic effects of xenobiotica, amongst others of important industrial and environmental chemicals. In this regard the expression of xenobioticametabolising P 450 enzymes in human CD 34+ bone marrow stem cells is a prerequisite for the local generation of reactive metabolites. Up to now P450 enzymes in human bone marrow , respectively in defined cell populations of human bone marrow are not yet sufficiently investigated. By means of investigating a larger number o findividual samples qualitative and quantitative information on P450 variability in CD 34+ cells will be generated with the aim to improve current limit value setting for substances with thisspecific toxic property.
Section overview
Subjects
- Biotechnology
