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Proteomic analysis of effects induced by 3-MCPD and 3-MCPD fatty acid esters in rat liver and kidney
Project
Project code: BfR-LMS-08-1322-452
Contract period: 01.04.2010
- 31.12.2011
Purpose of research: Applied research
The thermal treatment of fat-containing foodstuff in the presence of salt leads to the formation of 3-MCPD (3-monochloropropane-1,2-diol) fatty acid esters. Surprisingly high concentrations of 3-MCPD esters were detected in refined vegetable oils and fats and in milk powder used for the nutrition of infants. Upon hydrolytic cleavage, these substances are me-tabolized to 3-MCPD, which may lead to concentrations greatly exceeding the TDI. There exist toxicologic studies which indicate a clear carcinogenic potential of 3-MCPD. However, no information is available on the toxic potential of MCPD esters. In order to obtain first insights on potentially adverse effects of MCPD esters and to analyze molecular effects of 3-MCPD, proteomic investigations into 3-MCPD and 3-MCPD fatty acid ester induced changes of rat liver, kidney and testis have been encouraged.
Section overview
Subjects
- Biotechnology