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Proteomic analysis of effects induced by 3-MCPD and 3-MCPD fatty acid esters in rat liver and kidney

Project

Food and consumer protection

This project contributes to the research aim 'Food and consumer protection'. Which funding institutions are active for this aim? What are the sub-aims? Take a look:
Food and consumer protection


Project code: BfR-LMS-08-1322-452
Contract period: 01.04.2010 - 31.12.2011
Purpose of research: Applied research

The thermal treatment of fat-containing foodstuff in the presence of salt leads to the formation of 3-MCPD (3-monochloropropane-1,2-diol) fatty acid esters. Surprisingly high concentrations of 3-MCPD esters were detected in refined vegetable oils and fats and in milk powder used for the nutrition of infants. Upon hydrolytic cleavage, these substances are me-tabolized to 3-MCPD, which may lead to concentrations greatly exceeding the TDI. There exist toxicologic studies which indicate a clear carcinogenic potential of 3-MCPD. However, no information is available on the toxic potential of MCPD esters. In order to obtain first insights on potentially adverse effects of MCPD esters and to analyze molecular effects of 3-MCPD, proteomic investigations into 3-MCPD and 3-MCPD fatty acid ester induced changes of rat liver, kidney and testis have been encouraged.

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Subjects

Framework programme

BMEL Frameworkprogramme 2008

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