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Data Protection Declaration
Imprint
Method development for the identification of biomarkers for risk assessment of endocrine disruptors and phthalates
Project
Project code: BfR-PRS-08-1322-434
Contract period: 01.04.2010
- 31.12.2010
Purpose of research: Applied research
Phthalates are used as stabilizers in all sorts of consumer goods (e.g. PVC). Dibutylphthalat (DBP), diethylhexylphthalat (DEHP), diisononylphthalat (DINP), diisodecylphthalat (DIDP), butylbenzylphthalat (BBP) und di-n-octylphthalat (DNOP) are used as stabilizers in plastics. Phthalates are not covalently bound to the polymer matrix and are capable to migrate into objects in contact with the polymer. Some phthalates are known as endocrine disruptors. Especially the developing child may be affected by substances with known effects on the endocrine system.EU guideline 2005/84/EG was introduced to reduce the exposure of children to endocrine disruptors and the contents of three phthalates were reduced to less than 0.1% (w/w) in toys and baby goods. DINP, DIDP and DNOP were banned from products, which could get into oral contact with babies.The term endocrine disruptor was introduced by Colborn et al. in 1993. Endocrine disruptors are no specified chemical class. They all influence the endocrine system. Endocrine disruptors show estrogen receptor (ERalpha and ERbeta), androgen receptor (AR), progesteron recep-tor (PR), glucocorticoid receptor (GR) or mineralocorticoid receptor (CR) binding affinity. Bisphenol A, some phthalates, acylphenols, organo tin compounds and benzophenones are all suspected of being endocrine diruptors. Together, BMELV and BfR have specified a list of endocrine disruptors. The BfR has worked on the topic of consumer health risks that may be caused by chronic exposures to endocrine disruptors and the institute dealt with this issue in respect to EU regulation 793/93/EWG or the regulation of pesticides. The existing test systems for endocrine disruptors are exclusively (steroid hormone) receptor based and have only limited value for the actual risk assessment after exposure. There is no regulated guideline for the assessment of endocrine disruptors from consumer goods, therefore no actual risk assessment about toxicity of endocrine disruptors
Section overview
Subjects
- Food Chemistry
- Toxicology
