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Imprint
Identification of microsomal Epoxide hydrolase in human lung tissue
Project
Project code: BfR-CHS-08-1322-348
Contract period: 01.04.2008
- 31.12.2008
Purpose of research: Applied research
Toxic effects of chemicals are in many cases due to activating reactions leading to reactive metabolites. Reactive metabolites are able to damage cellular macromolecules. On the other hand, reactive metabolites can be enzymatically deactivated. The concentration of reactive metabolites is thus influenced by the balance between activating and deactivating processes. The project is aimed at the determination of microsomal epoxide hydrolase in human lung tissue. Microsomal epoxide hydrolase catalyses the hydroxylation of epoxides which represent an important class of reactive metabolites, formed by enzymatic activation via the action of cytochrome P450 enzymes.
Section overview
Subjects
- Biotechnology
- Toxicology
