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Screening assays for toxic and sensitizing substances in mixtures of azo dyes and its metabolites using human keratinocytes
Project
Project code: BfR-PRS-08-1322-292
Contract period: 01.03.2007
- 31.12.2007
Purpose of research: Applied research
The aim of the project is to study the potential additive or synergistic toxicity induced by the combined treatment of human keratinocytes (primary culture, HaCaT cell line) with defined mixtures of azo dyes and their metabolites (e.g. from hair dyes, textiles). In addition to the cytotoxic effects the induction of cytokine expression as a measure for the sensitizing potential of the substances and their mixtures is studied.
Section overview
Subjects
- Toxicology