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Proteomic investigations into silver nanoparticle-induced effects after 28-days subacute oral treatment in rats
Project
Project code: BfR-LMS-08-1322-543
Contract period: 01.03.2013
- 31.12.2016
Purpose of research: Applied research
Nanoparticles increasingly get into contact with food, e.g. by the use of contact materials like package material, refrigerators and cooking accessories, which show coatings of biocidal silver nanomaterials Available animal studies demonstrate increased silver particle concentrations in main target organs liver, spleen, testes, kidney, brain, lung and stomach Beside the bioaccumulation of nanosilver in different organs, the kinetic behavior of the material after oral uptake and digestion is particularly important. Depending on stability and coating, particles may enter sensitive cellular compartments and exhibit different toxicological properties compared to dissolved silver. Significantly different toxicological effects of nanosilver compared to ionic silver have yet been reported exclusively in vitro (Hussain et al. 2005, AshaRani et al. 2009). In order to obtain first insights into nanosilver induced effects and mechanisms in vivo, comparative proteomic analyses of rats which are orally exposed to nanosilver and ionic silver are envisaged. Depending on results, risk assessment could be revised and based on particle-specific properties of silver.
A 28-day rat in vivo study with oral delivery of silver nanoparticles, ionic silver and particle coating materials was designed in order to give first insights into nanosilver induced effects and mechanisms. The major focus is a comparative proteomic analysis of rats which are orally exposed to nanosilver and ionic silver. The study design provides the possibility to differentiate between a maximal ionic release of the particles as well as the influence of the nanoparticle-coating. Depending on results, risk assessment could be revised and based on particle-specific effects of silver.
Section overview
Subjects
- Toxicology
