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Imprint
Proteomic investigations into 2-MCPD and 2-MCPD-distearate-induced effects after 28-days subacute oral treatment in rats
Project
Project code: BfR-LMS-08-1322-542
Contract period: 01.03.2013
- 31.12.2014
Purpose of research: Applied research
Thermal treatment of fat-containing foodstuff in the presence of salt leads to formation of 3-MCPD fatty acid esters. Upon hydrolytic cleavage, these substances release 3-MCPD. The risk potential of this substance has been assessed by the BfR (experts opinion 2003). In animal studies, high doses of 3-MCPD displayed cancerogenic potential. In these studies, kidney and testis were the primary target organs. A preliminary TDI value of 2 µg/kg BW/day was derived. In addition to free 3-MCPD also high amounts of 3-MCPD fatty acid esters have been detected in fat-containing foodstuff such as margarine or vegetable oil, but also in baby food (dry milk powder) in 2007. In its experts opinion the BfR stated that these high amounts of 3-MCPD esters raised concern, because assuming total hydrolysis of the esters in the human intestinal tract, the amount of free 3-MCPD would significantly exceed its TDI value. Recent studies revealed that the foods mentioned above may also contain significant amounts of 2-MCPD fatty acid esters. In vivo, these related compounds might also undergo hydrolysis to release free 2-MCPD. Unpublished results point to similar toxicity of 2-MCPD compared to 3-MCPD (Marchesini, unpublished study report). No such studies exist for 2-MCPD esters. In order to complete risk assessments for 3-MCPD, 2-MCPD and their esters, further toxicological studies are required. Since first results from in vitro studies did not show significant effects of 2-MCPD and its esters, additional investigations should be performed in vivo.
Section overview
Subjects
- Toxicology
