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Imprint
Bioavailability of tenderisers in dust and food after oral intake in the model organism pig
Project
Project code: BfR-SiN-08-1322-555
Contract period: 01.01.2013
- 31.05.2016
Purpose of research: Applied research
The sensible group of young childrens ingest high amounts of dust via oral pathway; suggested values from the US EPA (2011) for the accepted daily intake is 60 mg (average consumer) respectively 100 mg (highest percentile). Phthalates are the main and toxicological relevant chemical compound in the dust (Uhl et al. 2004). Fromme et al. (2004) have detected maximum values of 27.400 mg DEHP/kg dust in different studies. In the risk assessment bioavailability of 100 per cent (worst-case scenario) was assumed, because data on the bioavailability of phthalates from dust and food does not exist. This could result in an overestimation of the interne exposure with phthalates after the intake via dust. Kang et al. (2012) have analysed a bioavailability of phthalates in dust from 10.2 % (DEHP) and 32 % (DMP). Consequently precautions could be taken, although they could not be justified by the current data. It is supposed that the amount of absorbable tenderiser from dust after oral intake is significantly lower than after intake with food with the consequence that the using of a 100 per cent bioavailability in the risk assessment is not justified.
According to the US-EPA, toddlers have an unintended daily uptake of 60-100 mg dust, which contains various pollutants. Especially phthalates are present in high amounts - a potential health risk. Currently, there is no information about the bioavailability of pollutants in the matrix dust. Our results show, that the bioavailability of phthalates is much higher compared to the in vitro digestion tests (~10-20%). Furthermore, it is noticeable that the bioavailability of e.g. DEHP does not vary within the dust samples. Besides diet and toys, dust could pose an additional source of plasticizers for toddlers.
Section overview
Subjects
- Physiology of Nutrition
- Toxicology
