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Risk evaluation for the quantitative estimation of the consequences of the oral application of antibiotics

Project


Project code: BfR-BIOS-08-1322-532
Contract period: 01.03.2012 - 31.12.2016
Purpose of research: Applied research

Subproject since 2015: Determination of the effect of the use of amoxicillin in broiler chicken on ocurrence and transmission probability of cephalosporin resistances in fecal Escherichia coli (E. coli) The aim of the study is to investigate the effect of groupwise and individual administration of amoxicillin to chickens on the development of cephalosporine-resistance among E. coli in these animals and untreated contact animals in comparison to untreated control animals without contact to the treated animals. The study aims at increasing the understanding of the specific role of the oral administration of antimicrobials for the development of resistance, especially with regard to the critically important cephalosporines, in broilers. The results of the study may help in developing recommendations for an improved antimicrobial use and reducing the problem of antimicrobial resistance in livestock. Hereby, the study aims at contributing to the protection of animal and human health.

In order to maintain the efficacy of antibiotics for animals and humans, administration via the drinking and feeding system is a risk factor. In this context, four research parts of the ORRES project were dealt with in 2016: 1) In a literature study (published 2016) on resistance factors in pigs, this and other starting points have been pointed out. 2) A pig experiment (manuscript) showed that in the case of enrofloxacin treatment of some animals of a group, untreated contact animals also take up the antibiotic enrofloxacin and that temporary resistance increases in E. coli against other antibiotic classes. 3)In a chicken experiment, animals were treated with amoxicillin, some via the drinker and others with a drencher. Blood serum (72 samples) as well as the contents of various intestinal sections (about 74 samples) were examined for amoxicillin and metabolite content. E. coli from rectal swabs (ca.1700 samples) are to be investigated with respect to resistances (previously approx. 960). Background, methodology and initial results are laid down in manuscript design. 4) In a field study on treatment and resistance factors in fattening pigs, 29 farms in Bavaria and NRW were visited and rectal samples, stock, maintenance and treatment data were collected, which were not yet fully reported to the BfR and are to be evaluated in 2017.

 

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BMEL - research cluster

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