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Übertragung von MRSA mit Herkunft bei Tieren auf Menschen auf der Grundlage von Populationsanalysen relevanter klonaler Linien und von prospektiven Studien
Project
Project code: keine Angabe
Contract period: 01.11.2010
- 31.10.2013
Purpose of research: Applied research
The project is aimed to provide robust data on transmission of livestock associated MRSA (LA-MRSA) to humans exposed to animals (farmers, veterinarians), further transmission to their non exposed contact persons and to humans in the community.
Cases of infections with MRSA exhibiting genomic characteristics typical for MRSA of animal origin and becoming apparent by sending in for typing to the National Reference Centre for staphylococci of will be traced back for association with animal husbandry. Cohorts of MRSA-positive farmers and veterinarians (including their families) from all over Germany and a control group will be established in order to study dynamics, risk factors for and clinical significance of colonization with MRSA.
Besides background data on epidemiological origin and on risk factors the study is based on comparative molecular typing and characterization of isolates of different human and animal origin. Starting from high throughput molecular typing by means of DNA-sequence polymorphisms of a key maker (spa gene) an analysis of the population structure within particular clonal lineages of interest based on genome wide analysis of single nucleotide polymorphisms (SNP’s) will be performed in order to detect subpopulations emerging in humans and in other animals hosts besides their original predominant animal reservoir. SNP’s will be used subsequently for the design of molecular markers for host adapted variants by high throughput detection methods.
In order to assess the significance of resistance to zinc ions exhibited by a substantial proportion of LA-MRSA 398 the prevalence of the corresponding resistance determinant(s) in MRSA of different clonal lineages and from different clinical sources (humans and animals) will be investigated.
Section overview
Subjects
- Animal health
Collaborative Project
Funding programme
Excutive institution
National Reference Center for Staphylococci and Enterococci (NRZ)
