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Coordinated project: ESBL and (fluoro)quinolone RESistance in EnTerobacteriaceae (RESET-II)
Project
Project code: BfR-BIOS-08-1334-220
Contract period: 01.04.2014
- 30.04.2017
Purpose of research: Applied research
The coordinated project RESET-II aims to contribute to a better understanding of the sources and spread of extended spectrum Beta-lactam-resistant and carbapenem-resistant Enterobacteria, and to use these data to identify intervention strategies. A risk assessment model for ESBLs, AmpC and carbapenemase-positive Enterobacteriaceae in Germany will be established. The research consortium RESET was set up to assess the impact of different origins, transmission routes and pathogen attributes on the risk for humans being exposed to Enterobacteriaceae which produce extended-spectrum Beta-lactamases (ESBL) and carry plasmid mediated (fluoro)quinolone-resistance (PMQR) genes. For this purpose, epidemiological and experimental investigations in humans, animals and plant production as well as in-depth molecular characterisation of isolates were performed. Based on this, RESET-II aims to identify the driving forces behind selection, transmission, colonization and infection. This will be a major step to highlight crucial points for resistance development in all populations. The hypothesis of the consortium to be verified within the project, are: The selection of bacteria as well as the hosts’ colonisation is a matter of specific characteristics of the isolates, the supposed host(s) and environmental factors. The transmission of resistance is linked to both, the genetic properties of the isolates and plasmids as well as the environment along the whole food production chain which bacteria are exposed to. To identify options for the intervention and the reduction of exposure to existing resistance it is necessary to relate quantitatively the isolate’s characteristics with detailed epidemiological data of the host and its environment.
Section overview
Subjects
- Toxicology
