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Mapping and exploitation of new sources of resistance to net blotch (Pyrenophora teres f. teres) in barley
Project
Project code: JKI-RS-08-1113
Contract period: 01.04.2010
- 31.03.2013
Purpose of research: Applied research
During the last decades an increase of food allergies in numbers and varieties is observed in many industrial (western) states. At the same time the contact risk is rising for all people. Plant breeding is a tool to contribute to prevention, reduction or avoidance of allergic potential for more safety and life quality of allergic persons. The main cause of baker's asthma is the CM3 subunit of the ?-Amylase-inhibitor of wheat (Nakamura et al. 2005). Recent data from our lab revealed that there is no allelic diversity for the only exon of the mature protein, but expression studies showed high differences between the different wheat varieties. In the project we will investigate the role of the differential expression using chromatin-immunoprecipitation and transcription factor binding studies. Further experiments are planned to elucidate the biological function of the CM3 subunit which is known to be involved in pathogen defense. The aim of the analyses is to identify less allergic genotypes which will help to reduce the contact risk and to prevent allergic development. The information about the differential expression of the CM3 subunit of the ?-Amylase inhibitor and the verification of transcription factor binding sites offers the possibility to apply conventional plant breeding approaches in combination with the knowledge in genome analyses to influence formation and structure of allergic substances - in this case the baker's asthma causing CM3 subunit of the ?-Amylase inhibitor.
Section overview
Subjects
- Plant Breeding
- Crop Protection
Framework programme
Funding programme
Excutive institution
Institute of Resistance Research and Stress Tolerance (JKI-RS)
