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Imprint
Dosimetry of Nanoparticles in in vitro experiments
Project
Project code: BfR-LMS-08-1322-637
Contract period: 01.01.2015
- 31.12.2016
Purpose of research: Applied research
Recently published research results in nanotechnology show an increasing importance of dosimetric approaches for in- vitro experiments. Nanomaterials show a decreased diffusion compared to ionic substances, whereas they show a slower sedimentation than larger aggregates. Hence, the delivered dose of nanomaterials is smaller than the administered dose of these substances. The ISDD-model (In-vitro sedimentation, diffusion and dosimetry model) describes these particle- and media-specific properties by bioinformatic calculation of an “effective dose”. The relevant factors and measured variables can be determined in experimental studies. Therefore, after detailed characterisation of the particles and in-vitro systems, it is possible to determine the respective delivered dose of certain nanomaterials in a defined time. These results can contribute to toxicological approaches. This project is meant to determine the effective doses of nanomaterials that are used in in-vitro experiments. It gives a big improvement of knowledge and accuracy for the determination of dose-response-relationships. The ISDD-model is to be established to make ongoing dosimetric studies of experimentally used naonmaterials practicable and reproducible. However, this project provides essential support to all recent studies on nanotechnology.
Section overview
Subjects
- Biotechnology
- Toxicology
