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Imprint
Bioactivity and mechanisms (antigenotoxic, antioxidative, modulation of signal transduction and barrier function) of food and food constituents
Project
Project code: MRI-PBE-08-08
Contract period: 01.01.2001
- 31.12.2028
Purpose of research: Basic research
Based on epidemiological studies, a high consumption of fruits and vegetables, accompanying uptake of phytochemicals (e.g. carotenoids, flavonoids), is related with a diminished risk for several disease. Molecular mechanisms of the effect of phytochemicals on the development of disease are not clearly assessed. Therefore, the effects of nutrients such as carotenoids and flavonoids on the following processes are addressed: induction of DNA strand breaks, formation of 8-oxoganine, apoptosis/necrosis, cell proliferation, intrazellular signaling, alteration of expression of associated proteins and gut permeability. Furthermore, the bioavailability of these nutrients is determined by use of appropriate cell systems (e.g. Caco-2/Transwell system).
Briviba K, Pan L, Rechkemmer G. (2002) Red wine polyphenols inhibit the growth of colon carcinoma cells and modulate the activation pattern of mitogen-activated protein kinases. J Nutr 132: 2814-2818. Briviba, K, Schnäbele, K, Schwertle, E, Blockhaus, M, and Rechkemmer, G. (2001) ß-Carotene Inhibits Growth of Human Colon Carcinoma Cells In Vitro by Induction of Apoptosis. Biol. Chem. 382: 1663-1668. Briviba, K, Abrahamse, SL, Pool-Zobel, BL, and Rechkemmer, G (2002), Neurotensin- and EGFinduced metabolic activation of colon carcinoma cells is diminished by the dietary flavonoid cyanidin but not by its glycosides. Cancer and Nutrition 41, 1-2, 172-179. Briviba K, Stracke BA, Rüfer CE, Watzl B, Weibel FP, Bub A. (2007) Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans. J Agric Food Chem. 55: 7716-7721. Briviba, K., Heinzow B, Schwenk M, et al., (2008) (Mitteilung der Kommission „Methoden und Qualitätssicherung in der Umweltmedizin“ des Robert Koch-Instituts) "Oxidativer Stress und Möglichkeiten seiner Messung aus umweltmedizinischer Sicht" In: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 51: 1464–1482, Springer-Verlag 2008. Briviba K (2008) DNA strand breaks and tomatoes In: Tomatoes and tomato products. (V.R. Preedy and R.R. Watson, eds.) Science Publishers, Enfield (NH), pp 386-394. Esselen M, Winkler S, Baechler S, Barth SW, Briviba K, Watzl B, Skrbek S, Marko D (2013) Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA strand breaking activity in the colon of Wistar rats. Carcinogenesis, 34, 835-840. Müller, A., Briviba, K, Gräf, V, Greiner, R, Herrmann, C, Kuballa, T, Stahl, MR (2013) UV-C treatment using a Dean vortex technology — impact on apple juice enzymes and toxicological potential. Innovative Food Science & Emerging Technologies, 20, 238-243. 1. Briviba, K., Gräf, V., Walz, E., Guamis, B., Butz, P. (2016) Ultra high pressure homogenization of almond milk: Physico-chemical and physiological effects. Food Chem. 192:82-89. Gille, A., Hollenbach, R., Trautmann, A., Gomez, M.R., Krüger, R., Bischoff, S.C., Posten, C., Briviba, K. (2020) Lipophilic compounds, but not fucoxanthin, mediate the genotoxic effect of photoautotrophic grown Phaeodactylum tricornutum in Caco-2 and HT-29 cells. Journal of Functional Foods, 64, art. no. 103671.
Section overview
Subjects
- Physiology of Nutrition
- Home Economics
- Food Chemistry
- Communication Sciences
- Biotechnology
- Resource management
- Genetic Resources
- Nutritional behaviour
- Process engineering
- Toxicology
- Renewable Resources
- Climate Change
- Computer science
Framework programme
Funding programme
Excutive institution
MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE)
