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Imprint
Integrated 'omics' approach for the identification of biomarkers for toxicological risk assessment of chemicals, nanomaterials and their mixtures including their potential to affect toxicologically relevant signaling pathways
Project
Project code: BfR-CPS-08-1322-642
Contract period: 01.01.2016
- 31.12.2018
Purpose of research: Basic research
Current toxicological research is focused on the effects of single substances, which are tested for toxicological endpoints like LD50 values or no adverse effect levels (NOAEL`s). However, in daily life scenarios the consumer is rather exposed to mixtures of substances at low-dose levels then to high concentrations of single compounds. Therefore the consideration of combinatorial effects like additive or synergistic interactions in substance mixtures with respect to the activation or inhibition of toxicological and signaling pathways is a paramount pre-requisite for a reliable human health risk assessment. In order to address this requirement, we plan to investigate potential non-additive combinatorial effects of chemicals in mixtures. In addition to soluble substances, also nanoparticles will be included in these studies. The tests will be performed in established cellular models like A549 alveolar cells as well as in tissues derived from mouse embryonic stem cells. The assessment of alterations in pathway activities will be done with metabolomic and proteomic experiments which are expected to allow for the detection of metabolic patterns and changed protein levels. These findings might lead to the identification of biomarkers which could be further used for risk assessment.
Section overview
Subjects
- Toxicology
