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Cellular uptake, metabolism and transport of food constituents in cell culture models
Project
Project code: MRI-PBE-08-13
Contract period: 01.01.2001
- 31.12.2028
Purpose of research: Applied research
Bioavailability of bioactive food compounds plays an important role for their bioactivity in human. Most of the nutrients are absorbed from the small intestine. The objective of the project is to investigate the molecular mechanisms of cellular uptake, metabolism and transepithelial transport of bioactive food compounds like polyphenols, carotenoids in a number of in vitro model systems such as in vitro digestion/Caco-2cell/Transwell model system.
See for references: Bub, A, Watzl, B, Heeb, D, Rechkemmer, G, and Briviba, K (2001) Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur J Nutr 40, 113-121. Watzl B, Bub A, Briviba K, Rechkemmer G (2002) Acute intake of moderate amounts of red wine or alcohol has no effect on the immune system of healthy men. Eur J Nutr 2002 41: 264-270. Watzl B, Bub A, Pretzer G, Roser S, Barth SW, Rechkemmer G. (2004) Daily moderate amounts or red wine or alcohol have no effect on the immune system of healthy men. Eur J Clin Nutr. 58: 40-45. Fleschhut J, Kratzer F, Rechkemmer G, Kulling SE (2005). Stability and biotransformation of various dietary anthocyanins in vitro. Eur J Nutr. 18: [Epub ahead of print] Briviba, K., Bornemann, R., Lemmer, U. (2006) Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy. Mol Nutr Food Res., 50, 991-995. Ribeiro HS, Schuchmann HP, Engel R, Briviba K, Walz E. (2009) Encapsulation of Carotenoids and Vitamins. In : Encapsulation Technologies for Food Active Ingredients and Food Processing. Eds.: N.J. Zuidam, V.A. Nedovic, Springer, pp211-252 Briviba K, Schollenberger M, Rodehutscord M, Greiner R (2017) Dephosphorylation of myo-inositol phosphates in the in vitro intestinal Caco-2 cell model. International Journal of Food Sciences and Nutrition, Vol. 69 (2018), H. 1S. 46-51 Briviba, K, Schnäbele, K, Schwertle, E, Blockhaus, M, and Rechkemmer, G. (2001) ß-Carotene Inhibits Growth of Human Colon Carcinoma Cells In Vitro by Induction of Apoptosis. Biol. Chem. 382: 1663-1668. Briviba, K., Bornemann, R., Lemmer, U. (2006) Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy. Mol Nutr Food Res., 50, 991-995. Ribeiro HS, Schuchmann HP, Engel R, Briviba K, Walz E. (2009) Encapsulation of Carotenoids and Vitamins. In : Encapsulation Technologies for Food Active Ingredients and Food Processing. Eds.: N.J. Zuidam, V.A. Nedovic, Springer, pp211-252 Briviba K, Schollenberger M, Rodehutscord M, Greiner R (2018) Dephosphorylation of myo-inositol phosphates in the in vitro intestinal Caco-2 cell model. International Journal of Food Sciences and Nutrition, Vol. 69, 46-51. Gille A., Hollenbach R., Trautmann A., Posten C., Briviba K. (2019). Effect of sonication on bioaccessibility and cellular uptake of carotenoids from preparations of photoautotrophic Phaeodactylum tricornutu. Food Research.118, pp. 40-48. Mayer-Miebach, E., Briviba, K., Schiffer, C., Geiger, L., Behsnilian, D., Greiner, R. Particle size of milled chokeberry pomace did not influence in vitro cellular absorption and transport efficiencies of anthocyanins, phenolic acids and flavonols (2019) International Journal of Food Sciences and Nutrition, 70 (8), pp. 932-940.
Section overview
Subjects
- Physiology of Nutrition
- Biotechnology
Framework programme
Funding programme
Excutive institution
MRI - Institute of Nutritional Epidemiology and Physiology - Karlsruhe (MRI-PBE)
