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The importance of farm, domestic and wild animals as a source of Ebola virus infection - collaborative project bezween the Friedrich-Loeffler-Institut, the Institut Pasteur de Guinée in Conakry, Guinea, Sierra Leone Agricultural Research Institut and the Njala University in Sierra Leone (Ebola Foresight)

Project

Food and consumer protection

This project contributes to the research aim 'Food and consumer protection'. Which funding institutions are active for this aim? What are the sub-aims? Take a look:
Food and consumer protection


Project code: 2815FSEBOL, FLI-IMVZ+INNT-08-HV-0028
Contract period: 01.03.2016 - 30.09.2019
Budget: 1,607,888 Euro
Purpose of research: Networks and research co-ordination
Keywords: zoonosis, animal health, animal species comprhensive, diagnostics, prevention, wildlife, virology, food safety

The project examines the role of livestock, domestic animals and wildlife as potential hosts in filovirus infections. The project will also investigate whether novel and so far unknown filoviruses circulate in these countries. It is planned to develop diagnostic assays such as novel sequencing techniques and serological tools for the detection of filovirus infections in relevant animal species. All of these techniques will then be implemented in the respective African partner laboratories and will avail rapid and specific responses to future outbreaks of zoonotic diseases. In complementation of the capacity building approach, on-site PhD students and laboratory staff will be trained in the respective techniques. Furthermore, the partner institutes will be enabled to establish successful and high-quality research projects in the long term. The molecular and serological studies will be complemented by additional experiments in the newly established high containment laboratory at the FLI.

1. Fischer, K., Jabaty, J., Suluku, R., et al., Serological Evidence for the Circulation of Ebolaviruses in Pigs From Sierra Leone. J Infect Dis, 2018. 218(suppl_5): p. S305-S311. 2. Müller, A., Fischer, K., Suluku, R. et al., Sequencing of mRNA from Whole Blood using Nanopore Sequencing. JoVE, 2019. 148, e59377 3. Fischer, K., Camara, A., Troupin, C., et al., Serological evidence of exposure to ebolaviruses in domestic pigs from Guinea. Transbound Emerg Dis, 2019. (in press) 4. Kamper, L., Zierke, L., Schmidt, M.L., et al., Assessment of the function and intergenus-compatibility of Ebola and Lloviu virus proteins. J Gen Virol, 2019. 188(5), 001261, pp.760-772 5. Gonzalez-Hernandez, M., et al., Calu-3cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L. Virology, 2019. 532: p. 22-29. 6. Fischer, K., Suluku, R., Fehling, S.K., et al., Presence of Ebola virus neutralizing antibodies in dogs from Sierra Leone. Emerg Infect Dis, 2020. Accepted for publication (17.01.2020).

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Subjects

Framework programme

BMEL Frameworkprogramme 2008

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