Effect of quercetin on biomarkers for cardiovascular risk in subjects with various apoE isoforms (intervention study)
Description:
In a clinical study the effect of quercetin on endothelial function and postprandial metabolic parameters in subjects of various apoE isoforms will be determined. Safety parameters will also be assessed. The various apoE isoforms contain different amounts of SH-groups. It is assumed that this affects oxidizability of apoE-containing lipoproteins and susceptibility of a person to oxidative stress. Subjects homocygous for apoE4 are probably particularly susceptible, and could profit most from consumption of antioxidants. Quercetin has antioxidative properties
Executive Institute:
MRI - Department of Physiology and Biochemistry of Nutrition (MRI-PBE) Details of MRI - Department of Physiology and Biochemistry of Nutrition
Parent institution:
Max Rubner-Institut - Federal Research Institute of Nutrition and Food (MRI) Details of (MRI) (Baden-Württemberg)
Contract period:
01. 09. 2006 - 30. 08. 2009
Participating Institutions:
- Christian-Albrechts-University of Kiel (CAU) Details of CAU
- University Medical Center Hamburg-Eppendorf (UKE) Details of UKE
Funding Programme:
- BMELV / Core funding Details of BMELV / Core funding
Subject:
- Food Chemistry
Purpose of research:
Basic research
Funding Institutions:
- Federal Ministry of Food, Agriculture and Consumer Protection (BMELV) Details of (BMELV)
Project Management Agency:
- Federal Ministry of Food, Agriculture and Consumer Protection (BMELV) Details of BMELV