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Search for: erz0sxl5g8vvmvn4ys3t2pck0tnkfwpqiy0xemsfsppa1u1ofavfhpib7g9htmdy, 10 of 7966 ResultsSorting
Relevancy: 35%
Interaction between metabolism and transport of toxicologically relevant compounds in the gastrointestinal barrier (Project)
...Intestinal resorption of cancerogenic contaminants of food such as the polycyclic aromatic hydrocarbon (PAHs) benzo[a]pyrene (B[a]P) is affected by the interaction of CYP1A1/CYP1B1, phase II XMEs and ABC-transport proteins. ...During the first phase of this project we studied the mechanism of detoxification of the ultimate carcinogenic phase I B[a]P metabolite anti-B[a]P-7,8-diol-9,10-epoxide (BPDE). Formation of glutathione (GSH) conjugates mediated by glutathione-S-transferases (GSTs) as well as the excretion of these conjugates was analysed. ...It will comprise a) the influence of the flavonol quercetin, b) the role of the BCRP (use of the bcrp-/- knockout mice) as well as c) the role of MRP2/3 using the mrp2/3 double knockout mice....
Funding period: 2010 - 2013
Relevancy: 35%
Climate-resilient cultivation methods for risk optimization – with special consideration of the goals of the arable farming strategy and their regional requirements - subproject ZALF (Project)
...ZALF focuses on two main areas in KARO. On the one hand, 1) agronomic adaptation strategies are developed and translated into regional cropping systems with reference to the Arable Farming Strategy 2035 (SWP 3.1); 2) the agronomic risk is determined (SWP 4.2); 3) the arable cropping systems are optimised (SWP 6.1). On the other hand, 1) regionally differentiated crop yield and cropping patterns & ecosystem services, including their trade-offs and synergies, are identified and quantified (SWP 3.4) and applied to three risk levels by including agronomic and economic risks in the derivation of crop yield and cropping patterns & ecosystem services. (SWP 4.2); 2) environmental risks are assessed and a contribution to the risk assessment is made (SWP 4.5-4.6); 3) an optimisation with regard to environmental risk is made in order to minimise trade-offs and promote synergies (SWP 6.4). ...
Funding period: 2024 - 2027
Relevancy: 35%
Building a Typology of European Rural Areas for the Spatial Impact Assessment of Policies (Project)
...The following results were obtained: 1) A typification depicting the diversification of the rural economy for the NUTS-3 level 2) A typification depicting the human capital for the NUTS-3-level 3) A typification depicting the competitiveness of agricultural enterprises for the NUTS-3-level 4) A typification depicting the agricultural sustainability for the NUTS-3-level 5) An EU-wide structural typology for the NUTS-2-level 6) Exemplary linking of the diversification typology of the rural economy with an economic input-output-model 7) Exemplary analysis of the consequences of two rural policy measures (diversification of the rural economy, village renewal). ...
Funding period: 2008 - 2009
Relevancy: 35%
Determination of coumarin in different food samples (Project)
...From the European Food Safety Authority (EFSA) a Tolerable Daily Intake (TDI) of 0.1 mg/kg body weight was established. In Germany during the last years in food surveillance high concentrations of coumarin (up to 10g/kg) in cinnamon were measured. ...To enable also the analysis of samples with lower coumarin concentrations existing methods have to be optimised in regard to limit of detection. The developed method(s) should be validated by different validation concepts. With the developed method the concentrations of coumarin in different cinnamon containing food samples (e.g. tea, other beverages) and the influence of their preparation on the coumarin concentration will be determined. The concentrations of coumarin in other samples should be investigated. Since only some data on the bioavailability of coumarin from the different food materials are available in an animal experiment with a small number of animals the bioavailability of coumarin from coumarin containing products will be investigated....
Funding period: 2007 - 2007
Relevancy: 35%
Production of milk on pasture or with zero-grazing: an process analysis (Project)
...The project addresses the following questions regarding 'pasture versus stable', in cooperation between research and practice: 1. Effects on animal health, behaviour and well-being 2. Effects on digestion 3. Strategies for optimizing pasture systems 4. Requirements for environment and climate friendly, resource-efficient dairy production 5. farm economic evaluation 6. Consumers preferences and acceptance Focus of the contribution of Thünen Institute is on topic 4. ...
Funding period: 2013 - 2017
Relevancy: 35%
Migration of nanosilver and nanoclay from food packaging materials into food (Project)
...For this purpose a masterbatch with LDPE (ExxonMobil™ LDPE LD 100) as polymer basis, which contains AgPURE™ nanosilver (rent a scientist GmbH, D99 under 20nm), was extruded to films with a thickness of 40 µm and a nanosilver content in the range of 500 ppm to ca. 11000 ppm (film 3 - 7). A film made of LDPE without nanosilver was produced as blank test material. ...The highest silver release was determined to be 6.8 ± 0.8 µg/dm2 with film 7 and 3% acetic acid and the lowest silver release was observed in the commercially available films in trace concentrations ranging from 3 ± 1 ng/dm2 to 33 ± 3 ng/dm2. ...For the test series the fillets were packed in nanosilver containing bags (blank and film 1 – 4) and for reference in sterile whirl-packs and stored at 4°C in refrigerator for 7 days. 10 colonies were randomly picked for bacterial diagnostics to check, whether the bacterial flora have changed in composition due to different storage conditions. ...
Funding period: 2009 - 2017
Relevancy: 35%
The serotonin transporter gene in the laying hen and its relation to feather pecking (Project)
...The hypothesis is that mutations in the serotonin transporter gene (g-sert) could be partly responsible for these effects. ...The number of feather pecks (severe or gentle) and aggressive pecks given and received were recorded on an individual basis twice a day (1 h/morning and 1 h/afternoon) for 23 days at the age of 32 to 35 weeks. ...Severe feather pecking was the predominant type of pecking (on average 7.8, 1.3 and 3.6 severe, gentle and aggressive pecks given per hen, respectively) and therefore only severe feather pecking is presented here....
Funding period: 2006 - 2014
Relevancy: 35%
ERA-WoodWisdom: ReWoBioRef - Mobilisation and utilisation of recycled wood for lignocellulosic biorefinery processes. Subproject 1: Characterisation and selection, microeconomic and environmental assessment, coordination (Project)
...WP 1: Characterization of recycled waste wood materials and selection criteria for pre-treatment steps WP 2: Pre-Treatment methods for recycled wood mixtures WP 3: Valorisation of waste wood fractions into high-value products WP 4: Microeconomic and environmental assessments for the waste wood recycling industry WP 5: Transnational dissemination activities WP 6: Project Management...
Funding period: 2014 - 2017
Relevancy: 35%
ERA-WoodWisdom: ReWoBioRef - Mobilisation and utilisation of recycled wood for lignocellulosic biorefinery processes. Subproject 2: Optimization of the pretreatment and of the pulping of waste wood (Project)
...WP 1: Characterization of recycled waste wood materials and selection criteria for pre-treatment steps WP 2: Pre-Treatment methods for recycled wood mixtures WP 3: Valorisation of waste wood fractions into high-value products WP 4: Microeconomic and environmental assessments for the waste wood recycling industry WP 5: Transnational dissemination activities WP 6: Project Management...
Funding period: 2014 - 2017
Relevancy: 35%
Molecular effects of flavonoid quercetin on human primary hepatocytes compared to those in mouse liver (Project)
...Due to its predicted anti-inflammatory, anti-oxidative and anti-carcinogenic properties food supplements with a daily intake up to 2 g were recommended. However, the effects of such a high dose on humans can not be assessed. An in vivo study in mice revealed that orally given quercetin (10 mg/kg body weight for 3 days) causes a drastic change in mRNA pattern in the liver of fed mice compared to control animals. 1790 genes were identified to be differentially regulated with a fold change of 2 and a q-value of 0.05. In this study human primary hepatocytes should be used to analyse the molecular effects of quercetin on human liver The liver hepatocytes should be exposed to 3 different human relevant doses of quercetin covering the normal intake up to the dose ingested by supplements. ...
Funding period: 2013 - 2014
