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Search for: erz0sxl5g8vvmvn4ys3t2pck0tnkfwpqiy0xemsfsppa1u1ofavfhpib7g9htmdy, 10 of 7966 ResultsSorting
Relevancy: 31%
Berlin-Brandenburg Research Platform BB3R with Integrated Graduate Education 'Innovations in the 3R Research - Genetic Engineering, Tissue Engineering and Bioinformatics' - Subproject 4: 'Individualized pain suppression in mice' (Work program Dept. 9) and 'Development of a nanotoxicology test platform for testing the inhalation toxicity of nanoparticles in vitro' (work program Dept. 7) (Project)
...The establishment of the Berlin-Brandenburg research platform BB3R with integrated graduate education will strengthen the 3R expertise of the region Berlin-Brandenburg. ...While the analgesic effect of buprenorphine increased in C57BL/6J and Balb/cJ mice with the higher administered dose, the analgesic effect remained stable in 129S1/SvImJ mice. Serum and blood concentrations of buprenorphine and its metabolites were dose and partly strain dependent (4.0 mg/kg dose group). ...Toxicology, (2018). Jul 1; 404-405:76-85. doi: 10.1016/j.tox.2018.06.001. ...
Funding period: 2014 - 2018
Relevancy: 31%
Site-directed genome modification of cereal elite material through DNA integration-free delivery of RNA-guided Cas endonuclease via haploidy-inducing crosses (Project)
...These include wheat x maize, barley x Hordeum bulbosum and maize x phospholipase A1 knockout (pla1A-KO) maize. Upon genetic transformation of such haploidy-inducing lines using guide-(g)RNA and Cas expression units, respective transcript and ribonucleoprotein is produced and transferred in their sperm via pollination and fertilization to hybrid zygotes formed on the female parent. ...In the DELITE project, we envisage to genetically transform Hordeum bulbosum and pla1A-KO maize line RWK using barley and maize target gene-specific gRNA/Cas constructs, respectively. ...The approach pursued has several advantages over current methods. (1) Site-directed alterations may be achieved in an unprecedented variety of genotypes including elite germplasm, since the use of haploidy-inducing lines is considered far less genotype dependent as compared with conventional methods of plant regeneration from transiently or stably transformed cells. (2) Once a gRNA/Cas-transgenic haploidy inducer plant is available for a given target gene, it can be readily utilized for targeted genome modification even in breeders' facilities, where haploid and genotyping technology is typically established. (3) As cross-pollinations can be performed at virtually unlimited scope, just a single gRNA/Cas-transgenic haploidy inducer plant is sufficient to generate a whole variety of mutant lines. (4) The principle is associated with reduced modification of off-targets, because the presence of gRNA and Cas is confined to the period of early embryogenesis. (5) Thanks to the elimination of the discrete, transgene-carrying genome from the developing embryo, the site-specifically modified genome of the produced plants is kept free from any transgenes during the whole process. (6) The preliminarily haploid genome of these plants is identically duplicated, thus homozygous individuals can be instantly obtained whose genetic modification will be genetically fixed as well....
Funding period: 2018 - 2020
Relevancy: 31%
Exposure pathways for lead in the human organism (Project)
...Am J Public Health. 2012;102(4):714-22. Epub 2011-08-20. doi: 10.2105/Ajph.2011.300161. 3. ...Ann Glob Health. 2016;82(1):197-201. doi: 10.1016/j.aogh.2016.01.016. 4. ...Environ Res. 2007;103(1):30–7. doi: 10.1016/j.envres.2006.05.009....
Funding period: 2018 - 2019
Relevancy: 31%
Interaction between metabolism and transport of toxicological relevant compounds in the gastrointestinal barrier (Project)
...Intestinal resorption of cancerogenic contaminants of food such as the polycyclic aromatic hydrocarbon (PAHs) benzo[a]pyrene (B[a]P) is affected by the interaction of CYP1A1/CYP1B1, phase II XMEs and ABC-transport proteins. ...In the project we here apply for the mechanism of detoxification of the ultimate carcinogenic phase I B[a]P metabolite anti-B[a]P-7,8-diol-9,10-epoxide (BPDE) will be studied. Formation of glutathione conjugates mediated by glutathione-S-transferases (GSTs) as well as the excretion of these conjugates will be analysed. ...
Funding period: 2005 - 2009
Relevancy: 31%
Sustainable Nutrition (Project)
...In: Oltersdorf, U.: Claupein, E.; Pfau, C.; Stiebel, J. (eds.): Consumer & Nutrition: Challenges and Chances for Research and Society, Berichte der Bundesforschungsanstalt für Ernährung und Lebensmittel, Band 2, Karlsruhe, 214-216, 2005. http://www.bfa-ernaehrung.de/Bfe-Deutsch/Information/e-docs/bfel2.pdf Claupein, E.: Welche Bedeutung hat Nachhaltigkeit beim Ernährungsverhalten? ...Wissenschaftlichen Kongress der Deutschen Gesellschaft für Ernährung, Kiel, Proc. Germ. Nutr. Soc. 7, 29, 2005 Eisinger-Watzl M, Heuer T, Wittig F, Hoffmann I: Nationale Verzehrsstudie II: Ernährungsverhalten bezüglich klimawirksamer Faktoren. ...Erika Claupein, Forschungsfelder 1/Mai 2016, 15...
Funding period: 2001 - 2020
Relevancy: 31%
Collaborative project: Introducing new health traits in Brown Swiss breeding by establishing a female reference population for genomic selection. Subproject 1 (Project)
...The project is based on 8 working packages (WP). WP 1 includes logistics in genotyping and data processing. ...WP 3 covers the concept for sample collection and selection of animals. In WP 4 and 5 all activities related to practical genotyping and phenotyping are covered. ...
Funding period: 2017 - 2021
Relevancy: 31%
Collaborative project: Introducing new health traits in Brown Swiss breeding by establishing a female reference population for genomic selection. Subproject 2 (Project)
...The project is based on 8 working packages (WP). WP 1 includes logistics in genotyping and data processing. ...WP 3 covers the concept for sample collection and selection of animals. In WP 4 and 5 all activities related to practical genotyping and phenotyping are covered. ...
Funding period: 2017 - 2021
Relevancy: 31%
Collaborative project: Introducing new health traits in Brown Swiss breeding by establishing a female reference population for genomic selection. Subproject 3 (Project)
...The project is based on 8 working packages (WP). WP 1 includes logistics in genotyping and data processing. ...WP 3 covers the concept for sample collection and selection of animals. In WP 4 and 5 all activities related to practical genotyping and phenotyping are covered. ...
Funding period: 2017 - 2021
Relevancy: 31%
Collaborative project: Introducing new health traits in Brown Swiss breeding by establishing a female reference population for genomic selection. Subproject 4 (Project)
...The project is based on 8 working packages (WP). WP 1 includes logistics in genotyping and data processing. ...WP 3 covers the concept for sample collection and selection of animals. In WP 4 and 5 all activities related to practical genotyping and phenotyping are covered. ...
Funding period: 2017 - 2021
Relevancy: 31%
Collaborative project: Introducing new health traits in Brown Swiss breeding by establishing a female reference population for genomic selection. Subproject 5 (Project)
...The project is based on 8 working packages (WP). WP 1 includes logistics in genotyping and data processing. ...WP 3 covers the concept for sample collection and selection of animals. In WP 4 and 5 all activities related to practical genotyping and phenotyping are covered. ...
Funding period: 2017 - 2021
