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Relevancy: 100%
Expression analysis of drug-metabolizing enzymes in human keratinocytes after treatment with selected xenobiotics (Project)
Toxification of xenobiotic compounds usually requires enzymatic conversion by metabolizing enzymes. For benzo[a]pyrene (BaP) we have demonstrated that metabolite patterns differ significantly in keratinocytes from other cell lines, such as lung carcinoma A549 or HepG2 cells. This observation is important, as BaP is known to be metabolized by the same enzymes in all of these cells, i.e. CYP1A1,...
Funding period: 2009 - 2010
Relevancy: 100%
Identification of novel molecular biomarkers enabling reliable assessment of endocrine distruptor activity in-vitro (Project)
Steroid hormones like estrogens and androgens act via intracellular ligand-dependent transcription factors. Binding of the ligand results in homo- or heterodimerization of receptors and binding at specific DNA elements in genomic DNA. The conformational change induced by hormone binding leads to interaction with cofactors which in turn may lead to the repression or activation of the transcription...
Funding period: 2009 - 2010
Relevancy: 100%
2009: Development of a method suited to identify epigenetic effects in cells in culture upon exposure to low doses of model compounds, 2010: Investigation of epigenetic effects of consumer product-related model compounds in vitro (Project)
2009: Adverse effects of xenobiotics may result, for instance, from inhibition of enzymes, from disruption of signal transduction cascades or from direct modification of coding DNA. Recent studies recovered that chemical compounds could also affect the metabolism by varying gene expression profiles at the level of epigenetic mechanisms. These heritable phenomena that regulate gene expression...
Funding period: 2009 - 2010
Relevancy: 100%
Genomics-based approach for the utilization of the secondary gene pool for a sustainable barley breeding (TRANS-BULB), sub-project A (Project)
no details
Funding period: 2012 - 2014
Relevancy: 100%
Plant biotechnology of the future - A genomics assisted approach to tap the potential of the secondary gene pool for sustainable barley breeding (TRANS-BULB) - Subproject C (Project)
In barley breeding, the wild species Hordeum bulbosum (Hb) has the potential to serve as resource of novel variability in valuable traits which so far has only scarcely been used. A number of novel barley-disease resistances have been introgressed from H. bulbosum to cultivated barley (Hordeum vulgare ssp. Vulgare, Hv) via interspecific crosses, among them dominantly inherited resistances to the...
Funding period: 2012 - 2015
Relevancy: 100%
Qualitative and quantitative analysis of toxicological relevant matters in the mainstream smoke of the waterpipe (Project)
In Germany the term smoking is generally associated with smoking of cigarettes. However, during the last years a new kind of smoking has become increasingly popular, especially among young people, that is the waterpipe tobacco smoking. Surveys from different geographic regions demonstrate that waterpipe tobacco smoking is a global trend and not only restricted to the Middle Eastern region.At...
Funding period: 2009 - 2010
Relevancy: 100%
Scented toys: Exposure of infants against allergenic scents - Research on the analysis and biological effects of allergens in toys (Project)
The numbers of children suffering from various kinds of allergies has been found constantly increasing over recent times. According to certain estimates, fragrance ingredients represent the second most common cause for allergies induced during childhood while nickel is most common. Toys are scented to inspire consumers for purchasing those products, to cover unpleasant odors and smells and/or to...
Funding period: 2009 - 2010
Relevancy: 100%
Chemical Imaging of Human Cells after Exposure to Metal Oxide Nanoparticles in vitro (Project)
Their UV ray absorbing properties make nano-sized metal oxides such as zinc and titanium oxide a common ingredient in products such as sunscreens, but it is also used in paints, plastics and other commodities. Opposed to these positive features are the largely unknown health risks. Possible toxic effects posed by nano-sized particles in part may be due to their different physico-chemical...
Funding period: 2009 - 2010
Relevancy: 100%
Development of new methods for the identification of animal proteins in feedingstuff. Real-time immuno-PCR for the detection of animal bone and tissue marker 2010: Validation of an immunological method for the detection of Osteocalcin representing a stable bone tissue marker in Meat and Bone Meal (MBM) (Project)
Feeding of animal protein to farmed animals is - with just a few exceptions - not allowed according to Regulation (EC) No. 999/2001. The official method for the detection of animal particles in feed is based on microscopy Regulation (EC) No. 152/2009). However, microscopy cannot distinguish animal species. Further quantitative analysis poses a problem as demonstrated in ring trials organised by...
Funding period: 2008 - 2010
Relevancy: 100%
The role of microRNAs in regulation of bovine ovarian follicular development (Project)
no details
Funding period: 2012 - 2015
