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Relevancy: 100%
Proteomic investigations of carcinogenic effects in primary rat hepatocytes: prevalidation of an in vitro hepatic model for detection of non-genotoxic carcinogens (Project)
Toxicogenomic approaches represent a potential tool for predictive toxicology and for gathering information about the involved mechanism of action of toxicants. At present this tech-nology is mostly used in vivo in order to obtain information on toxicity mechanisms from short-term studies for the risk assessment of substances. With regard to the ethical problems as well as the high requirement of...
Funding period: 2009 - 2011
Relevancy: 100%
Food authentication by Food-Fingerprinting with NMR spectroscopy and other spectroscopic techniques (Project)
The aim of this proposal is to develop a strategy for food authenticity control based on nuclear magnetic resonance (NMR) and FT-IR fingerprint methods. These methods provide various information about food composition due to the simultaneous detection of all nuclei (1H or 13C) in NMR spectroscopy and all bonds between nuclei in FT-IR spectroscopy. Es-pecially the detection of changes in food...
Funding period: 2009 - 2011
Relevancy: 100%
Feeding of contaminated feed with melamine to laying hens to determine the carry over rate of melamine in eggs. (Project)
Melamine is a chemical intermediate used in the manufacture of amino resins and plastics. Other end products include countertops, fabrics, glues and flame retardants.In Europe, melamine is approved for use as a monomer and as an additive in plastics and is forbidden in feed and food (Commission Decision of 14 October 2008).In 2008, high levels of melamine in infant milk and other milk products...
Funding period: 2009 - 2011
Relevancy: 100%
Mechanisms and minimisation of matrix effects in quantitative trace analytics with electrospray mass spectrometry (Project)
no entry
Funding period: 2009 - 2011
Relevancy: 100%
National strategy for food reformulation: evaluation of international reformulation initiatives (Project)
no details
Funding period: 2016 - 2017
Relevancy: 100%
Marine Biotoxins: Analysis of the toxic effects of okadaic acid metabolites. Follow-up of Development of an in-vitro screening test of marine toxins based on embryonic stem cells (Project)
Okadaic acid is produced by dinoflagellates and can accumulate in different shellfish species. Consumption of okadaic acid can induce diarrhoea, nausea and vomiting. Besides these acute toxic effects also carcinogenic and embryotoxic effects of okadaic acid have been shown. Biotransformation of okadaic acid leads probably to toxification in contrast to detoxification of many other substances....
Funding period: 2008 - 2011
Relevancy: 100%
Determination of fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD) in foodstuffs (Project)
3-chloro-1,2-propanediol (3-MCPD) is a food-borne contaminant found in a wide range of retail processed foods. The occurrence of fatty acid esters of 3-MCPD is also described in literature. At the end of 2007 the CVUA Stuttgart detected extremely high levels of 3-MCPDesters in refined plant oils and fat containing foods, amongst others in nougat spread and infant formula.As a consequence of, the...
Funding period: 2008 - 2011
Relevancy: 100%
Development of a biotransformation system for the metabolic activation of validated in vitro systems to study embryotoxicity (Project)
no entry
Funding period: 2008 - 2011
Relevancy: 100%
Determination of CYP2F-related enzyme activities in human lung tissue (Project)
CYP2F enzymes are predominantly expressed in lung tissue. CYP2F enzymes are involved in the activation of industrially important chemicals as e.g. styrene. Up to now, CYP2F in human lung has only been detected at the mRNA level, but not at the level of the functionally active protein. The project is aimed at establishing a methodology in order to quantify CYP2F-associated enzyme activity in human...
Funding period: 2007 - 2011
Relevancy: 100%
Investigations of the mechanism of matrix effects occurring during ionization in LC-MS/MS instruments. Development of proposals to enhance the accuracy of residue determinations. (Project)
The matrix effect is the most important reason for the determination of less accurate concentrations of any analytes by LC-MS/MS instruments. The project is designed to understand the basic mechanisms and to offer ways to avoid or correct the errors caused by matrix effects.
Funding period: 2007 - 2011
