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2009: Skin Penetration of Substances from Consumer Products 2010: Combined Migration and Skin Permeation of Phthalates from Consumer Products (Project)

2009: For consumers the use of many consumer products is associated with skin contact and the dermal exposure to several chemicals. To assess possible health risks it is necessary to determine the amount of chemicals migrating from consumer products and therefore can become locally and systemically available.The use of in-vitro methods to assess skin penetration has been recognized as appropriate...


Funding period: 2009 - 2010

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Development of a contact allergen-induced T-cell assay using Langerhans cells: 2009: Expression of lineage specific T-cell transcription factors as biological endpoint suitable to indicate chemical induction of sensitization 2010: Measurement and quantification of transcription factors via qRT-PCR and FACS (Project)

Culture systems of dendritic cells are currently in the focus regarding development of in vitro test methods for sensitizing compounds present in consumer products. Allergen-reactive cytotoxic T-cells are responsible for typical tissue damages arising in the process of contact dermatitis. In order to imitate such type IV allergic reactions in skin of experimental animals, in this project...


Funding period: 2009 - 2010