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Relevancy: 100%
Proteome analysis of liver cells from Beta-catenin-mutated mice as a tool to get insight into the role of the oncoprotein for the tumor promotion by chemical substances (Project)
Tumor promotion by phenobarbital or phenobarbital-type agents such as PCB153 consists in a positive selection for hepatocytes with activating mutations in the Beta-catenin gene (ctnnb1). The underlying mechanism is unknown. Amongst others, Beta-catenin is a transcrip-tional regulator partly involved in the regulation of gene expression in liver. The analysis of the β-catenin-controlled proteome...
Funding period: 2006 - 2008
Relevancy: 100%
Identification of new molecular proteomic biomarker for the risk assessment of food related compounds; heat-tox products as important example (furan fatty acids and 3-MCPD) (Project)
Furan fallty acids (FFA) are formed due to the heat treatment of unsatturated fatty acids but also are of natural origin in fish oils or some plants. BMELV announced at the last SKLM meeting in December 2007 that BfR has to make a principal risk assessment to this class of heat tox compounds. However, only few data to generate a full risk assessment are avail-able. The SKLM emphases the need of a...
Funding period: 2006 - 2008
Relevancy: 100%
CC LandStraD, Subproject 5: Legal environment and spatial planning control systems (Project)
The subproject focuses on the regulatory system of environmental and spatial planning instruments according to land use and its management. It contributes to enhance the understanding of complex interdependencies between land use decisions, e.g. of land owners on one hand, and the socio-economic as well as statutory and informal framework of contemporary governance on the other. So the...
Funding period: 2010 - 2015
Relevancy: 100%
Experimental studies on the effect of probiotics by means of challenge with pathogenic microorganisms (Project)
The efficiency of probiotic supplementation (Enterococcus faecium) for the reduction of pathogenic agents modelling Salmonella Typhimurium DT 104 was investigated with a challenge study in pigs. Results of bacteriological examination reveal that faecal shedding of salmonellae was higher in pigs which received the probiotic strain and also the bacterial manifestation in organs was significantly...
Funding period: 2005 - 2008
Relevancy: 100%
CC LandStraD, Subproject 6: Participatory approaches of land use management (Project)
Recent experience has shown that insufficient integration of regional and local stakeholders poses a considerable threat to the successful implementation of sustainable land use strategies. Therefore, subproject 6 engages in a participatory and transdisciplinary multi-stakeholder dialogue. Stakeholder integration shall allow for capturing potential challenges for the implementation of sustainable...
Funding period: 2009 - 2015
Relevancy: 100%
Skin penetration in vitro (Project)
For consumers the use of cosmetics and commodities is associated with skin contact and the dermal exposure to several chemicals. To assess possible health risks it is necessary to determine the amounts of chemicals that become locally and systemically available from cosmetics or from migrates of commodities. Skin penetration of the known skin sensitizer 2-mercaptobenzothiazole (MBT) shall be...
Funding period: 2005 - 2008
Relevancy: 100%
Overweight and obesity in children, adolescents and young adults as a systemic risk (Project)
no entry
Funding period: 2005 - 2008
Relevancy: 100%
Gastric cell lines to substitute native cells of the gastric gland to study acid secretion in special consideration of preclinical studies (Project)
Novel approaches to study gastric acid secretion in vitro focus on the substitution of the usage of animal. In vitro models such as isolated gastric glands or gastric exocrine cells such as the gastric parietal cell bear several disadvantages. As these isolates from stomachs of animals are only to culture for several days, the complicated multi-step preparation has often to be repeated which...
Funding period: 2005 - 2008
Relevancy: 100%
Project to develop Animal Risk Assessment Guidelines on housing and management (Animal Welfare)(CFP/EFSA/AHAW/2009/01) Work package 2: Hazard identification and characterisation, and exposure assessment (Project)
The current project is proposed to define the components of RA related to the welfare of production animals and to provide conclusions and guidelines for future applications using a further developed methodology for this particular purpose. Specifically, the project aims to review the current state of the art regarding housing and management of cattle, sheep, goats, pigs and poultry, to identify...
Funding period: 2009 - 2010
Relevancy: 100%
Joint project: Pluripotent stem cells in automated prediction of developmental osteotoxizität. Subproject 3: Development and establishment of a Osteoblsten differentiation assays (Project)
no entry
Funding period: 2009 - 2010
