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Relevancy: 100%
Microbial protein synthesis in the rumen when fed by species-rich grassland growths of organic farming (Project)
In the ecologically oriented ruminant feeding is to increase efficiency of N utilization of particular importance, especially as egg white or components not only in the limited dimensions available. The production is ecologically and economically produced on greatly depending on the grassland forage quality. The aim of the project is through controlled feeding studies to determine the...
Funding period: 2007 - 2009
Relevancy: 100%
Development and evaluation of alternative methods to replace animal experiments (NIH-Test) for the potency measure of vaccines against rabies (Project)
Rabies vaccines are usually based on cell culture derived purified and inactivated virus. In contrast to veterinary vaccine preparations, which contain aluminium hydroxide or aluminium phosphate as adjuvants, vaccines to be used in humans are usually free of adjuvants. Licensing of rabies vaccines includes the demonstration of vaccine efficacy in the target species. Moreover before release of...
Funding period: 2007 - 2010
Relevancy: 100%
Preparation for external prevalidation: Optimization of the internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro by determination of the angiogenic standard of the cells to be used (Project)
The aim of the project is the optimization of an internally validated and standardized method for quantitation of angiogenesis and antiangiogenesis in vitro. This method is based on in vitro cultivation of microvascular endothelial cells. The cells were stimulated by growth media and showed characteristic morphological changes, which could be assigned to the phases of the angiogenic cascade in...
Funding period: 2007 - 2010
Relevancy: 100%
Establishment of normal human neural progenitor cells as an in vitro screening model for the evaluation of the neurotoxic potential of chemicals (Project)
The new EU Regulation on dealing with registration, evaluation, authorisation and restriction of chemical substances (REACH) entered into force of 1 June 2007. REACH demands the evaluation of the neurotoxic potential of chemicals which are produced with a volume > 1t. This includes new as well as existing chemicals. Currently, neurotoxicity testing is based on OECD guidelines and demands in vivo...
Funding period: 2007 - 2010
Relevancy: 100%
Molecular Toxicity of conjugated linoleic acid isomers and branched chain fatty acids; The role of the nuclear receptor PPAR in colon carcinogenesis (Project)
The investigation of potential cellular-toxic characteristics of trans fatty acids (TFAs) on the human colon carcinoma cell line Caco-2 is the major intent in this project. The mechanisms of TFA in development of colorectal carcinoma ought to be analysed by modern cell- and molecular-biological methods. Regulatory biomarkers for TFA treatment in Caco-2 shall be identified by genomic approach. The...
Funding period: 2006 - 2010
Relevancy: 100%
Quantification of residues of coccidiostats in feed and food of animal origin caused by carry over from contaminated feed. (Project)
Coccidiostats are licensed as feed additives for the prevention and treatment of coccidiosis. They can be used at approved concentrations in a certain time interval for broilers, turkey and young chickenup to an age of 16 weeks but not for laying hens. In the EU decoquinate, monensin, robenidine, lasalocid, halofuginone, narasin, salinomycin, maduramicin and diclazuril are registered as feed...
Funding period: 2006 - 2010
Relevancy: 100%
Improvement of the embryonic stem cell test (EST) using neural marker genes for testing the developmental neurotoxicity in vitro (Project)
Given the significant potential of chemicals and drugs to interfere with development of the nervous system, regulatory test guidelines have been adopted for the prediction and as-sessment of developmental neurotoxicity (U.S.EPA OPPTS 870.6300 and OECD TG 426). However, current in vivo test methods are laborious, costly and necessitate the use of high numbers of laboratory animals. Around 1000...
Funding period: 2004 - 2010
Relevancy: 100%
Molecular mechanisms of furan-mediated liver toxicity (Project)
The chemical furan is a conditional of manufacturing contaminant that was found in many foods. Animal studies demonstrated its mutagenic and cancerogenic potential. In these studies, liver was shown to be the primary target organ. Direct genotoxicity is presumably due to the oxidation of furan to the mutagenic substance cis-2-butene-1,4-dial mediated by the liver enzyme Cyp2E1. However,...
Funding period: 2009 - 2009
Relevancy: 100%
Studies on the prevalence of Escherichia coli pathovar-induced diarrhea in newborn piglets in organic piglet producing farms (Project)
The first goal of the research project is therefore to examine the prevalence of diarrheal pathogens in piglets in organic production sow farms. The occurrence of E. coli pathovars in differential diagnosis, differentiation from other organisms should be present in the foreground. In addition to possible additional risk factors in terms of housing conditions and the hygiene management are...
Funding period: 2009 - 2011
Relevancy: 100%
Prevalence of 'Distomum muscularis suis' in wildlife populations (Project)
During the investigation of wild boar in Brandenburg as an incidental finding of repeated Duncker `proven Scheme muscle ule. The Duncker `sche muscle ule is a precursor of living parasitically sucking worm from Alaria alata dar. In the Federal Institute for Risk Assessment (BfR) created for this purpose risk assessment, the danger was seen that consumers from eating infected, improperly cooked...
Funding period: 2008 - 2010
